US4866161A
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Inhibition of tartar deposition by polyanionic/hydrophobic peptides and derivatives thereof which have a clustered block copolymer structure
Assignee: University of South Alabama
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Filing: 1987-08-24
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Granted: 1989-09-12
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Expires: 2007-08-24
Abstract
Abstract A method of treating a tooth so as to inhibit deposition of a mineral thereon, which comprises contacting the tooth with a mineral deposition inhibitory effective amount of a poly-amino acid compound which has the structure: poly(X).sub.n poly(Y).sub.m where each X is a residue independently selected from the group consisting of aspartic acid, glutamic acid, phosphoserine, phosphohomoserine, phosphotyrosine, and phosphothreonine, each Y is independently a residue selected from the group consisting of alanine, leucine, isoleucine, valine and glycine, n is 2 to 60, m is 2 to 60, and n+m<5, and wherein poly (X) n may contain up to 10% of the Y residues and poly (Y) m may contain up to 10% of the X residues, and salts thereof, in combination with an orally acceptable vehicle compatible with said compound.
Inventors
- 👤 C. Steven Sikes
- 👤 A. P. Wheeler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 18:07
CPC Classifications
A; A61; A61Q; A61Q11/00; A61K; A61K8/00; A61K8/18; A61K8/72; A61K8/84; A61K8/88
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
139 words
A method of treating a tooth so as to inhibit deposition of mineral thereon, which comprises contacting said tooth with a mineral deposition inhibitory effective amount of a poly-amino acid compound which has the clustered polyanionic/clustered non-ionic, partly hydrophobic structure: poly (X).sub.n poly (Y).sub.m where each X is a residue independently selected from the group consisting of aspartic acid, glutamic acid, phosphoserine, phosphohomoserine, phosphotyrosine, and phosphothreonine, each Y is independently a residue selected from the group consisting of alanine, leucine, isoleucine, valine and glycine, n is 2 to 60, m is 2 to 60, and n +m >5, and wherein poly (X) n may contain up to 10% of the Y residues and poly (Y) m may contain up to 10% of the X residues, and salts thereof, in combination with an orally acceptable vehicle compatible with said compound.
Claim 2
Independent Claim
139 words
A method of treating a tooth so as to inhibit deposition of mineral thereon, which comprises contacting said tooth with a mineral deposition inhibitory effective amount of a poly-amino acid compound which has the clustered polyanionic/clustered non-ionic, partly hydrophobic structure: poly (X).sub.n poly (Y).sub.m where each X is a residue independently selected from the group consisting of aspartic acid, glutamic acid, phosphoserine, phosphohomoserine, phosphotyrosine, and phosphothreonine, each Y is independently a residue selected from the group consisting of alanine, leucine, isoleucine, valine and glycine, n is 2 to 60, m is 2 to 60, and n +m >5, and wherein poly (X) n may contain up to 10% of the Y residues and poly (Y) m may contain up to 10% of the X residues, and salts thereof, in combination with an orally acceptable vehicle compatible with said compound.
Claim 3
Dependent Claim
36 words
A method according to claim 1, in which the first X residue in the poly-amino acid compound is at the N-terminal of said compound and the last Y residue is at the C-terminal of said compound.
Claim 4
Dependent Claim
36 words
A method according to claim 1, in which the first X residue in the poly-amino acid compound is at the C-terminal of said compound and the last Y residue is at the C-terminal of said compound.
Claim 5
Dependent Claim
60 words
A method according to claim 1, wherein the poly-amino acid compound has a formula selected from the group consisting of: H.sub.2 N-(Asp).sub.n --(Ala).sub.m --OH H.sub.2 N-(Ala).sub.m --(Asp).sub.n --OH H.sub.2 N-(pSer).sub.n --(Ala).sub.m --OH H.sub.2 N-(Ala).sub.m --(pSer).sub.n --OH H.sub.2 N-(Glu).sub.n --(Ala).sub.m --OH H.sub.2 N-(Ala).sub.m --(Glu).sub.n --OH H.sub.2 N-(Ala).sub.m --(Asp).sub.n --(pSer).sub.x --OH, and H.sub.2 N-(Ala).sub.m --(Glu).sub.n --(pSer).sub.x --OH wherein: n=10-60, m=2-10, and x=2-5.
Claim 6
Dependent Claim
21 words
A method according to claim 4, wherein the poly-amino acid compound is: H 2 N-(Ala) 5 --(Asp) 18 --(pSer) 2 --OH.
Claim 7
Dependent Claim
19 words
A method according to claim 4, wherein the poly-amino acid compound is: H 2 N-(Ala) 5 --(Asp) 15 --OH.
Claim 8
Dependent Claim
19 words
A method according to claim 4, wherein the poly-amino acid compound is: H 2 N-(Ala) 8 --(Asp) 40 --OH.
Claim 9
Dependent Claim
26 words
A method according to claim 1, wherein in the formula for the poly-amino acid compound, n=20-40, m=2-8, and the number of phosphorylated amino acids is 0-3.
Claim 10
Dependent Claim
28 words
A method according to claim 1, wherein said aspartic acid and glutamic acid residues in said poly-amino acid compound are in the form of sodium or potassium salts.
Claim 11
Dependent Claim
30 words
A method according to claim 1, wherein said phosphoserine, phosphohomoserine, phosphotyrosine, and phosphothreonine residues in said poly-amino acid compound are in the form of disodium, dipotassium, calcium or magnesium salts.
Claim 12
Dependent Claim
14 words
A method according to claim 1, wherein said tooth is that of a human.
Claim 13
Dependent Claim
121 words
A dentifrice composition, which comprises a mineral deposition inhibitory effective amount of a poly-amino acid compound which has the clustered polyanionic/clustered non-ionic, partly hydrophobic structure: poly (X).sub.n poly (Y).sub.m where each X is a residue independently selected from the group consisting of aspartic acid, glutamic acid, phosphoserine, phosphohomoserine, phosphotyrosine, and phosphothreonine, each Y is independently a residue selected from the group consisting of alanine, leucine, isoleucine, valine and glycine, n is 2 to 60, m is 2 to 60, and n+m≧5, and wherein poly (X)n may contain up to 10% of the Y residues and poly (Y)m may contain up to 10% of the X residues, and salts thereof, in combination with an orally acceptable dentifrice composition compatible with said compound.
Claim 14
Dependent Claim
121 words
A dentifrice composition, which comprises a mineral deposition inhibitory effective amount of a poly-amino acid compound which has the clustered polyanionic/clustered non-ionic, partly hydrophobic structure: poly (X).sub.n poly (Y).sub.m where each X is a residue independently selected from the group consisting of aspartic acid, glutamic acid, phosphoserine, phosphohomoserine, phosphotyrosine, and phosphothreonine, each Y is independently a residue selected from the group consisting of alanine, leucine, isoleucine, valine and glycine, n is 2 to 60, m is 2 to 60, and n+m≧5, and wherein poly (X)n may contain up to 10% of the Y residues and poly (Y)m may contain up to 10% of the X residues, and salts thereof, in combination with an orally acceptable dentifrice composition compatible with said compound.
Claim 15
Dependent Claim
46 words
A composition according to claim 12, in the form of an oral hygiene formulation selected from the group consisting of mouthwashes, rinses, irrigating solutions, abrasive gel dentifrices, nonabrasive gel dentrifices, denture, cleansers, coated dental floss, interdental stimulator coatings, chewing gums, lozenges, breath fresheners, foams and sprays.
Claim 16
Dependent Claim
37 words
A dentifrice composition according to claim 12, in which the first X residue in the poly-amino acid compound is at the N-terminal of said compound and the last Y residue is at the C-terminal of said compound.
Claim 17
Dependent Claim
37 words
A dentrifrice composition according to claim 12, in which the first X residue in the poly-amino acid compound is at the C-terminal of said compound and the last Y residue is at the N-terminal of said compound.
Claim 18
Dependent Claim
60 words
A dentrifrice composition according to claim 12, wherein the poly-amino acid compound has a formula selected form the group consisting of: H.sub.2 N-(Asp).sub.n --(ala).sub.m --OH H.sub.2 N-(Ala).sub.m --(Asp).sub.n --OH H.sub.2 N-(pSer).sub.n --(Ala).sub.m --OH H.sub.2 N-(Ala).sub.m -(pSer)n-OH H.sub.2 N-(Glu).sub.n --(Ala).sub.m --OH H.sub.2 N-(Ala).sub.m --(Glu).sub.n --OH H.sub.2 N-(Ala).sub.m --(Asp).sub.n --(pSer).sub.x --OH, and N.sub.2 N-(Ala).sub.m --(Glu).sub.n --(PSer).sub.x --OH wherein: n=10-60, m=2-10, and x=2-5.
Claim 19
Dependent Claim
18 words
A dentifrice composition according to claim 16, wherein the poly-amino acid compound is: H.sub.2 N-(Ala).sub.5 --(Asp).sub.18 --(pSer).sub.2 --OH.
Claim 20
Dependent Claim
20 words
A dentifrice composition according to claim 16, wherein the poly-amino acid compound is: H 2 N-(Ala) 5 --(Asp) 15 --OH.
Claim 21
Dependent Claim
20 words
A dentifrice composition according to claim 16, wherein the poly-amino acid compound is: H 2 N-Ala) 8 --(Asp) 40 --OH.
Claim 22
Dependent Claim
26 words
A dentifrice composition according to claim 16, wherein in the formula for the poly-amino compound, n=20-40, m=2-8, and the number of phosphorylated amino acids is 0-3.
Claim 23
Dependent Claim
29 words
A dentifrice composition according to claim 12, wherein said aspartic acid and glutamic acid residues in said poly-amino acid compound are in the form of sodium or potassium salts.
Claim 24
Dependent Claim
31 words
A dentrifrice composition according to claim 12, wherein said phosphoserine, phosphohomoserine, phosphotyrosin, and phosphothreonine residues in said poly-amino acid compound are in the form of disodium, dipotassium, calcium or magnesium salts.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-09-11 | 1993-03-13 | 1993-09-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-11 | 1997-03-13 | 1997-09-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-09-11 | 2001-03-13 | 2001-09-12 | $7700.00 | Window Closed / Lapsed |