US5051185A
Expired / Lapsed
US
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Absorbent of β2 -microglobulin
Assignee: Asahi Kasei Medical Co Ltd
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Filing: 1990-04-19
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Granted: 1991-09-24
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Expires: 2010-04-19
Abstract
Abstract An adsorbent for β 2 -microglobulin is disclosed, which comprises a water-insoluble carrier having supported thereon, as a ligand, at least one electrolyte selected from the group consisting of a polyamino acid, a polysaccharide, a synthetic high polymer, collagen having an isoelectric point of 9.5 or more, and gelatin having an isoelectric point of 6.5 or more, wherein said electrolyte has a molecular weight not less than 1,000 and an X value of more than 2.0, wherein X is a relationship regarding the skeleton structure of said electrolyte and is the sum of A and B, wherein A represents (the number of carbon atoms of the skeleton structure)-(the number of hydrophilic groups)/(the number of hydrophilic groups); and B represents |(the number of cationic groups)-(the number of anionic groups)|/(the number of hydrophilic groups). The adsorbent exhibits adsorptivity for β 2 -microglobulin at high efficiency and high selectivity.
Inventors
- 👤 Hiroyuki Watanabe
- 👤 Tadashi Yokoyama
- 👤 Naokuni Yamawaki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 05:48
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3679; B; B01; B01J; B01J20/00; B01J20/22; B01J20/26; B01J20/261; B01J20/262; B01J20/264; B01J20/28; B01J20/28002; B01J20/28004; B01J20/28014; B01J20/28016; B01J20/28023; B01J20/28033; B01J20/28054; B01J20/28057; B01J20/28059; B01J20/28078; B01J20/30; B01J20/3092; B01J20/32; B01J20/3202; B01J20/3206; B01J20/3208; B01J20/321; B01J20/3214; B01J20/3217; B01J20/3219; B01J20/3231; B01J20/3242; B01J20/3244; B01J20/3246; B01J20/3248; B01J20/3255; B01J20/3268; B01J20/3272; B01J20/3274; B01J20/3289; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0415; A61M2202/0421; B01J2220/00; B01J2220/50; B01J2220/58; G; G03; G03C; G03C1/00; G03C1/005; G03C1/04; G03C1/047; G03C2001/0471; Y; Y10; Y10S; Y10S210/00; Y10S210/902; Y10S210/903; Y10S210/905; Y10S530/00; Y10S530/81; Y10S530/812; Y10S530/813; Y10S530/815
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
147 words
An adsorbent for β 2 -microglobulin which comprises a water-insoluble carrier having supported thereon, as a ligand, at least one electrolyte selected from the group consisting of a polyamino acid, a polysaccharide, a synthetic high polymer, collagen having an isoelectric point of 9.5 or more, and gelatin having an isoelectric point of 6.5 or more, wherein said electrolyte contains at least one group exhibiting a positive or negative charge in a neutral electrolytic solution and has a molecular weight of not less than 1,000 and an X value or more than 2.0, wherein X is a relationship regarding the skeleton structure of said electrolyte and is the sum of A and B, wherein A represents (the number of carbon atoms of the skeleton structure)-(the number of hydrophilic groups)/(the number of hydrophilic groups); and B represents|(the number of cationic groups)-(the number of anionic groups)|/(the number of hydrophilic groups).
Claim 2
Dependent Claim
147 words
An adsorbent for β 2 -microglobulin which comprises a water-insoluble carrier having supported thereon, as a ligand, at least one electrolyte selected from the group consisting of a polyamino acid, a polysaccharide, a synthetic high polymer, collagen having an isoelectric point of 9.5 or more, and gelatin having an isoelectric point of 6.5 or more, wherein said electrolyte contains at least one group exhibiting a positive or negative charge in a neutral electrolytic solution and has a molecular weight of not less than 1,000 and an X value or more than 2.0, wherein X is a relationship regarding the skeleton structure of said electrolyte and is the sum of A and B, wherein A represents (the number of carbon atoms of the skeleton structure)-(the number of hydrophilic groups)/(the number of hydrophilic groups); and B represents|(the number of cationic groups)-(the number of anionic groups)|/(the number of hydrophilic groups).
Claim 3
Dependent Claim
35 words
The adsorbent for β 2 -microglobulin as claimed in claim 1, wherein said ligand is at least one electrolyte selected from the group consisting of a polyamino acid, a polysaccharide and a synthetic high polymer.
Claim 4
Dependent Claim
23 words
The adsorbent for β 2 -microglobulin as claimed in claim 2, wherein said ligand has a molecular weight of from 1,000 to 1,000,000.
Claim 5
Dependent Claim
28 words
The adsorbent for β 2 -microglobulin as claimed in claim 2, wherein said ligand has an X value of from greater than 2 but not more than 15.
Claim 6
Dependent Claim
19 words
The adsorbent for β 2 -microglobulin as claimed in claim 2, wherein said ligand is a polyamino acid electrolyte.
Claim 7
Dependent Claim
22 words
The adsorbent for β 2 -microglobulin as claimed in claim 5 wherein said polyamino acid electrolyte is poly(glutamic acid-alanine) or poly-(glutamic acid-alanine-tyrosine).
Claim 8
Dependent Claim
18 words
The adsorbent for β 2 -microglobulin as claimed in claim 2, wherein said ligand is a polysaccharide electrolyte.
Claim 9
Dependent Claim
17 words
The absorbent for β 2 -microglobulin as claimed in claim 7, wherein said polysaccharide electrolyte is diethylaminoethyl-dextran.
Claim 10
Dependent Claim
20 words
The adsorbent for β 2 -microglobulin as claimed in claim 1, wherein said ligand is a synthetic high polymer electrolyte.
Claim 11
Dependent Claim
25 words
The adsorbent for β 2 -microglobulin as claimed in claim 9, wherein said synthetic high polymer electrolyte is sodium sulfonated polystyrene or styrene-maleic acid copolymer.
Claim 12
Dependent Claim
43 words
The adsorbent for β 2 -microglobulin as claimed in claim 1, wherein said water-insoluble carrier has a double-layered structure composed of a water-insoluble material having a contact angle with air bubble in water of at least 20° and a polymer compatible with blood.
Claim 13
Dependent Claim
19 words
The adsorbent for β 2 -microglobulin as claimed in claim 11, wherein said water-insoluble material is an organic polymer.
Claim 14
Dependent Claim
28 words
The adsorbent for β 2 -microglobulin as claimed in claim 11, wherein said water-insoluble material has a contact angle with air bubble in water of at least 40°.
Claim 15
Dependent Claim
26 words
The adsorbent for β 2 -microglobulin as claimed in claim 11, wherein said polymer compatible with blood is a polymer having a nitrogen-containing basic functional group.
Claim 16
Dependent Claim
25 words
The adsorbent for β 2 -microglobulin as claimed in claim 14, wherein said polymer having a nitrogen-containing basic functional group is 2-hydroxyethyl methacrylate-diethylaminoethyl methacrylate copolymer.
Claim 17
Dependent Claim
20 words
The adsorbent for β 2 -microglobulin as claimed in claim 1, wherein said water-insoluble carrier is activated using an epoxide.
Claim 18
Dependent Claim
20 words
The adsorbent for β 2 -microglobulin as claimed in claim 1, wherein said water-insoluble carrier is activated using an epichlorohydrin.
Claim 19
Dependent Claim
18 words
The adsorbent for β 2 -microglobulin as claimed in claim 1, wherein said ligand is a collagen electrolyte.
Claim 20
Dependent Claim
19 words
The absorbent for β 2 -microglobulin as claimed in claim 18, wherein said collagen electrolyte is methylated atelocollagen Type-I.
Claim 21
Dependent Claim
18 words
The adsorbent for β 2 -microglobulin as claimed in claim 1, wherein said ligand is a gelatin electrolyte.
Claim 22
Dependent Claim
36 words
The adsorbent for β 2 -microglobulin as claimed in claim 20, wherein said gelatin electrolyte is an electrolyte obtained by the heat treatment under an acidic condition of collagen obtained by treating under an acidic condition.
Claim 23
Dependent Claim
20 words
The adsorbent for β 2 -microglobulin as claimed in claim 1, wherein said ligand is a collagen or gelatin electrolyte.
Claim 24
Dependent Claim
25 words
The adsorbent for β 2 =microglobulin as claimed in claim 22, wherein said collagen or gelatin electrolyte has molecular weight of from 10,000 to 500,000.
Claim 25
Dependent Claim
31 words
The adsorbent for β 2 -microglobulin as claimed in claim 22, wherein said collagen or gelatin electrolyte has an X value for from greater than 2 but not more than 25.
Claim 26
Dependent Claim
59 words
A method for cleaning or regenerating a body fluid derived from patients suffering from renal insufficiency or malignant tumor which comprises contacting said body fluid taken from the body with the adsorbent defined in claim 1, adsorbing and removing β 2 -microglobulin at a high efficiency and with specificity, and then returning the cleaned body fluids into the body.
Claim 27
Dependent Claim
18 words
The method as claimed in claim 25, wherein said body fluid is blood, plasma, serum, ascites or hydrothorax.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1994-09-23 | 1995-03-25 | 1995-09-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-09-23 | 1999-03-25 | 1999-09-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-09-23 | 2003-03-25 | 2003-09-24 | $7700.00 | Window Closed / Lapsed |