EP0225867A2
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EP
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Adsorbent and process for preparing the same
Assignee: Kanegafuchi Chemical Industry Co Ltd
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Filing: 1983-12-01
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Granted: —
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Expires: 2003-12-01
Abstract
Abstract Adsorbent for removing low and/or very low density lipoprotein from body fluid such as blood or plasma composed of water-insoluble porous hard gel with an exclusion limit of 10<6> to 10<9> daltons on which a polyanion compound and/or a sulfated compound is immobilized. The adsorbent is suitable for selective removal of VLDL and/or LDL, from blood or plasma in extracorporeal circulation treatment.
Inventors
- 👤 Nobutaka Tani
- 👤 Tsuneo Hayashi
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 06:29
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3679; B; B01; B01J; B01J20/00; B01J20/30; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3206; B01J20/3208; B01J20/3212; B01J20/3214; B01J20/3217; B01J20/3219; B01J20/3231; B01J20/3242; B01J20/3268; B01J20/327; B01J20/3272; B01J20/3274; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0415; A61M2202/0456; A61M2202/046
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
47 words
An adsorbent for removing low and/or very low density lipoprotein from body fluid in extracorporeal circulation treatment, which comprises a water-insoluble porous hard gel with exclusion limit of 10⁶ to 10⁹ daltons on which a polyanion compound and/or a sulfated compound is immobilized by a covalent linkage.
Claim 2
Dependent Claim
47 words
An adsorbent for removing low and/or very low density lipoprotein from body fluid in extracorporeal circulation treatment, which comprises a water-insoluble porous hard gel with exclusion limit of 10⁶ to 10⁹ daltons on which a polyanion compound and/or a sulfated compound is immobilized by a covalent linkage.
Claim 3
Dependent Claim
18 words
The adsorbent of Claim 1, wherein said water-insoluble porous hard gel is a water-insoluble porous polymer hard gel.
Claim 4
Dependent Claim
17 words
The adsorbent of Claim 2, wherein said water-insoluble porous polymer hard gel is a porous cellulose gel.
Claim 5
Dependent Claim
17 words
The adsorbent of Claim 1, wherein said water-insoluble porous hard gel is a porous inorganic hard gel.
Claim 6
Dependent Claim
28 words
The adsorbent of Claim 4, wherein said water-insoluble inorganic hard gel is a member selected from the group consisting of porous glass, porous silica gel and porous alumina.
Claim 7
Dependent Claim
19 words
The adsorbent of Claim 1, wherein said sulfated compound is a compound obtained by sulfation of a hydroxy-containing compound.
Claim 8
Dependent Claim
13 words
The adsorbent of Claim 6, wherein the sulfated compound is a sulfated carbohydrate.
Claim 9
Dependent Claim
13 words
The adsorbent of Claim 7, wherein the sulfated carbohydrate is a sulfated saccharide.
Claim 10
Dependent Claim
13 words
The adsorbent of Claim 8, wherein the sulfated saccharide is a sulfated polysaccharide.
Claim 11
Dependent Claim
26 words
The adsorbent of claim 9, wherein the sulfated polysaccharide is a member selected from the group consisting of heparin, dextran sulfate, condroitin sulfate and salts thereof.
Claim 12
Dependent Claim
44 words
The adsorbent of claim 10, wherein the dextran sulfate, a salt thereof or a mixture of the dextran sulfate and the salt has an intrinsic viscosity of not more than 0.12 dl/g and a sulfur content of not less than 15 % by weight.
Claim 13
Dependent Claim
14 words
The adsorbent of claim 6, wherein the sulfated compound is a sulfated polyhydric alcohol.
Claim 14
Dependent Claim
14 words
The adsorbent of claim 1, wherein the exclusion limit is 10⁶ to 10⁸ daltons.
Claim 15
Dependent Claim
25 words
The adsorbent of claim 1, wherein said polyanion compound and/or sulfated compound is immobilized in an amount of 0.02 to 100 mg/ml of bed volume.
Claim 16
Dependent Claim
26 words
The adsorbent of claim 14, wherein the polyanion compound and/or sulfated compound is immobilized in an amount of not less than 0.2 mg/ml of bed volume.
Claim 17
Dependent Claim
83 words
A process of preparing an adsorbent for removing low and/or very low density lipoprotein from body fluid in extracorporeal circulation treatment comprising a water-insoluble porous hard gel with exclusion limit of 10⁶ to 10⁹ daltons on which a polyanion compound and/or a sulfated compound is immobilized, wherein said water-insoluble porous hard gel is reacted with epichlorhydrin or a polyoxyrane compound to introduce epoxy groups on to the gel, and then the resulting epoxy-activated gel is reacted with the polyanion compound and/or sulfated compound.
Claim 18
Dependent Claim
83 words
A process of preparing an adsorbent for removing low and/or very low density lipoprotein from body fluid in extracorporeal circulation treatment comprising a water-insoluble porous hard gel with exclusion limit of 10⁶ to 10⁹ daltons on which a polyanion compound and/or a sulfated compound is immobilized, wherein said water-insoluble porous hard gel is reacted with epichlorhydrin or a polyoxyrane compound to introduce epoxy groups on to the gel, and then the resulting epoxy-activated gel is reacted with the polyanion compound and/or sulfated compound.
Claim 19
Dependent Claim
17 words
The process of claim 16, wherein said water-insoluble hard gel is a water-insoluble porous polymer hard gel.
Claim 20
Dependent Claim
17 words
The process of Claim 17, wherein said water-insoluble porous polymer hard gel is a porous cellulose gel.
Claim 21
Dependent Claim
76 words
The process of Claim 16, wherein said sulfated compound is dextran sulfate, a salt thereof or a mixture of the dextran sulfate and the salt; said dextran sulfate, the salt thereof or the mixture of the dextran sulfate and the salt being reacted with the epoxy-activated gel in a concentration of not less than 3 % by weight based on the weight of the whole reaction system excluding the dry weight of the porous hard gel.
Claim 22
Dependent Claim
15 words
The process of Claim 19, wherein the porous hard gel is a porous cellulose gel.
References Cited (Backward Citations)
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