US5047236A
Expired / Lapsed
US
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Method of treating stroke
Assignee: Emory University
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Filing: 1990-05-11
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Granted: 1991-09-10
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Expires: 2010-05-11
Abstract
Abstract In accordance with the present invention, a method is provided for treating stroke. More particularly, the present invention relates to a method for treating stroke comprising injecting a solution of certain ethylene oxide-propylene oxide condensation surface-active copolymers. The solution of surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O) b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000, preferably approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the compound.
Inventors
- 👤 Robert L. Hunter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 09:55
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/74; A61K31/765; A61K38/00; A61K38/16; A61K38/164; A61K38/166; A61K38/43; A61K38/44; A61K38/446; A61K38/46; A61K38/48; A61K38/49
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
102 words
A method for treating stroke in a human or animal comprising the step of injecting into the human or animal with the stroke a solution with an effective concentration of a surface-active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 2
Independent Claim
102 words
A method for treating stroke in a human or animal comprising the step of injecting into the human or animal with the stroke a solution with an effective concentration of a surface-active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 3
Dependent Claim
77 words
The method of claim 1 wherein the surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 4
Dependent Claim
49 words
The method of claim 1 wherein the surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 and the total molecular weight of the compound is approximately 8400.
Claim 5
Independent Claim
103 words
A method for treating stroke in a human or animal comprising the step of injecting intravenously into the human or animal with the stroke a solution with an effective concentration of a surface-active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 6
Independent Claim
103 words
A method for treating stroke in a human or animal comprising the step of injecting intravenously into the human or animal with the stroke a solution with an effective concentration of a surface-active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 7
Dependent Claim
77 words
The method of claim 4 wherein the surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 8
Dependent Claim
49 words
The method of claim 4 wherein the surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 and the total molecular weight of the compound is approximately 8400.
Claim 9
Independent Claim
102 words
A method for treating stroke in a human or animal comprising the step of injecting intramuscularly into the human or animal with the stroke a solution with an effective concentration of a surface-active copolymer with the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 10
Independent Claim
102 words
A method for treating stroke in a human or animal comprising the step of injecting intramuscularly into the human or animal with the stroke a solution with an effective concentration of a surface-active copolymer with the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 11
Dependent Claim
79 words
(New Claim) The method of claim 7 wherein the surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 12
Dependent Claim
49 words
The method of claim 7 wherein the surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 and the total molecular weight of the compound is approximately 8400.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1994-09-09 | 1995-03-11 | 1995-09-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-09-09 | 1999-03-11 | 1999-09-10 | $3760.00 | Window Closed / Lapsed |
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