Antihypercholesterolemic compounds

Claim 1

A compound represented by the structural formulae (I) or (II): ##STR16## wherein: R 1 is: (1) C 1-10 alkyl; (2) substituted C 1-10 alkyl in which one or more substituent(s) is (a) halogen, (b) hydroxy, (c) C 1-10 alkoxy, (d) C 1-5 alkoxycarbonyl, (e) C 1-5 acyloxy, (f) C 3-8 cycloalkyl, (g) phenyl, (h) substituted phenyl in which the substituents are X and Y, (i) C 1-10 alkylS(O) n , (j) C 3-8 cycloalkylS(O) n , (k) phenylS(O) n , (l) substituted phenylS(O) n in which the substituents are X and Y, and (m) oxo; (n) nitrile, (o) NR 3 R 4 , (p) CONR 3 R 4 ; (3) C 1-10 alkoxy; (4) C 2-10 alkenyl; (5) C 3-8 cycloalkyl; (6) substituted C 3-8 cycloalkyl in which one substituent is (a) C 1-10 alkyl (b) substituted C 1-10 alkyl in which the substituent is (i) halogen, (ii) hydroxy, (iii) C 1-10 alkoxy, (iv) C 1-5 alkoxycarbonyl, (v) C 1-5 acyloxy, (vi) phenyl, (vii) substituted phenyl in which the substituents are X and Y (viii) C 1-10 alkylS(O) n , (ix) C 3-8 cycloalkylS(O) n , (x) phenylS(O) n , (xi) substituted phenylS(O) n in which the substituents are X and Y, and (xii) oxo, (c) C 1-10 alkylS(O) n , (d) C 3-8 cycloalkylS(O) n , (e) phenylS(O) n , (f) substituted phenylS(O) n in which the substituents are X and Y, (g) halogen, (h) hydroxy, (i) C 1-10 alkoxy, (j) C 1-5 alkoxycarbonyl, (k) C 1-5 acyloxy, (l) phenyl, and (m) substituted phenyl in which the substituents are X and Y; (7) phenyl; (8) substituted phenyl in which the substituents are X and Y; (9) amino; (10) C 1-5 alkylamino; (11) di(C 1-5 alkyl)amino; (12) phenylamino; (13) substituted phenylamino in which the substituents are X and Y; (14) phenyl C 1-10 alkylamino; (15) substituted phenyl C 1-10 alkylamino in which the substituents are X and Y; (16) a member selected from the group consisting of: (a) piperidinyl, (b) pyrrolidinyl, (c) piperazinyl, R 2 is H or CH 3 ; R 3 and R 4 are independently selected from: (a) C 1-5 alkyl; (b) substituted phenyl in which the substituents are X and Y; A is --CH 2 --; X and Y are independently selected from: (a) OH; (b) halogen, (c) trifluoromethyl, (d) C 1-3 alkoxy, (e) C 1-3 alkylcarbonyloxy, (f) phenylcarbonyloxy, (g) C 1-3 alkoxycarbonyl, (h) phenyloxycarbonyl, (i) hydrogen, (j) C 1-5 alkyl; Z is selected from (1) hydrogen; (2) C 1-5 alkyl; (3) substituted C 1-5 in which the substituent is selected from (a) phenyl, (b) dimethylamino, and (c) acetylamino, and (4) 2,3-dihydroxypropyl; halogen is Cl or F; n is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.