US4733003A
Expired / Lapsed
US
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Octahydronaphthalene derivatives and their preparation
Assignee: Sankyo Co Ltd
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Filing: 1986-05-06
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Granted: 1988-03-22
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Expires: 2006-05-06
Abstract
Abstract Compounds of formula (I): ##STR1## [wherein X represents a hydrogen atom or a 2-methylbutyryl group, Y represents a hydrogen atom or a methyl group and R 1 and R 2 are the same or different and each represents an oxygen atom or a group of formula ═N--OR 3 (wherein R 3 represents a hydrogen atom or an alkyl group)], the free hydroxy-carboxylic acids corresponding thereto and salts and esters of said acids may be prepared by oxidizing and, if necessary, oximating a corresponding ML-236A, ML-236B, MB-530A or MB-530B compound, and these compounds have valuable antihypercholesteraemic activity.
Inventors
- 👤 Junya Ide
- 👤 Shigeki Muramatsu
- 👤 Yoshio Tsujita
- 👤 Msao Kuroda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 21:42
CPC Classifications
C; C07; C07C; C07C65/00; C07C65/01; C07C59/00; C07C59/40; C07C59/76; C07C59/90; A; A61; A61P; A61P3/00; A61P3/06; C07D; C07D309/00; C07D309/16; C07D309/28; C07D309/30; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/18; C07F7/1804; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
86 words
A compound of the formula (II): ##STR17## wherein X represents a hydrogen atom or a 2-methylbutyryl group; Y represents a hydrogen atom or a methyl group; R 1 and R 2 are the same or different and each represents an oxygen atom or a group of formula ═N--OR 3 wherein R 3 represents a hydrogen atom or an alkyl grouo and with the proviso that at least one of R 1 and R 2 is ═N--OR 3 ); or a pharmaceutically acceptable salt or ester thereof.
Claim 2
Dependent Claim
86 words
A compound of the formula (II): ##STR17## wherein X represents a hydrogen atom or a 2-methylbutyryl group; Y represents a hydrogen atom or a methyl group; R 1 and R 2 are the same or different and each represents an oxygen atom or a group of formula ═N--OR 3 wherein R 3 represents a hydrogen atom or an alkyl grouo and with the proviso that at least one of R 1 and R 2 is ═N--OR 3 ); or a pharmaceutically acceptable salt or ester thereof.
Claim 3
Dependent Claim
40 words
The compound as claimed in claim 1, having the formula (VII): ##STR18## wherein X, Y, R 1 and R 2 are as defined in claim 1, M represents a metal atom and n is the valency of the metal M.
Claim 4
Dependent Claim
31 words
The compound as claimed in claim 1, wherein M represents a metal atom selected from the group consisting of lithium, sodium, potassium, calcium, magnesium, aluminium, iron, zinc, copper, nickel and cobalt.
Claim 5
Dependent Claim
21 words
The compound as claimed in claim 2, wherein M represents a metal selected from the group consisting of sodium and potassium.
Claim 6
Dependent Claim
42 words
A compound as claimed in claim 2, having the formula (VIII): ##STR19## wherein X, Y, R 1 and R 2 are as defined in claim 2, A represents ammonia, or a pharmaceutically acceptable salt of a monoamine and m is an integer.
Claim 7
Dependent Claim
44 words
The compound as claimed in claim 1, having the formula (IX): ##STR20## wherein X, Y, R 1 and R 2 are as defined in claim 1, R 8 represents the alcoholic moiety of an ester and p represents the valency of R 8 .
Claim 8
Dependent Claim
55 words
The compound as claimed in claim 6 wherein R 8 represents an alkyl group, a benzyl group, a benzyl group having at least one substituent selected from alkyl groups, alkoxy groups and halogen atoms, a phenacyl group or a phenacyl group having at least one substituent selected from alkyl groups, alkoxy groups and halogen atoms.
Claim 9
Dependent Claim
15 words
The compound as claimed in claim 6, wherein R 8 represents a lower alkyl group.
Claim 10
Dependent Claim
16 words
The compound as claimed in claim 6, wherein R 8 represents a methyl or ethyl group.
Claim 11
Dependent Claim
28 words
The compound as claimed in claim 1, in the form of a metal hydroxyimino salt of a carboxylate salt or carboxylate ester of said compound of formula (II).
Claim 12
Dependent Claim
24 words
The compound as claimed in claim 10, wherein said metal of said hydroxyimino salt is selected from the group consisting of sodium and potassium.
Claim 13
Dependent Claim
42 words
The compound as claimed in claim 1, having the formula (II): wherein X represents a 2-methylbutyryl group; Y represents a hydrogen atom; R 1 represents an oxygen atom; and R 2 represents a group of formula ═N--OH; or the sodium salt thereof.
Claim 14
Dependent Claim
44 words
The compound as claimed in claim 1 having the formula (II): wherein X represents a 2-methylbutyryl group; Y represents a hydrogen atom; R 1 represents an oxygen atom; and R 2 represents or group of formula ═N--O -- ; or the disodium salt thereof.
Claim 15
Dependent Claim
45 words
The compound as claimed in claim 1, having the formula (II): wherein X represents a 2-methylbutyryl group; Y represents a methyl group; R 1 represents an oxygen atom; and R 2 represents a group of formula ═N--OH; or the sodium salt or disodium salt thereof.
References Cited (Backward Citations)
US4438277A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-03-22 | 1991-09-21 | 1992-03-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-03-22 | 1995-09-21 | 1996-03-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-03-22 | 1999-09-21 | 2000-03-22 | $7700.00 | Window Closed / Lapsed |