Novel HMG-CoA reductase inhibitors

Claim 1

A compound represented by the following structural formula (I): ##STR49## wherein: R is ##STR50## R 1 and R 5 are independently: (1) C 1-10 alkyl; (2) substituted C 1-10 alkyl in which one or more substituent(s) is: (a) halogen, (b) hydroxy, (c) C 1-10 alkoxy, (d) C 1-5 alkoxycarbonyl, (e) C 1-5 acyloxy, (f) C 3-8 cycloalkyl, (g) phenyl, (h) substituted phenyl in which the substituents are X and Y, (i) C 1-10 alkylS(O) n in which n is 0 to 2, (j) C 3-8 cycloalkylS(O) n , (k) phenylS(O) n , (l) substituted phenylS(O) n in which the substituents are X and Y, and (m) oxo; (3) C 1-10 alkoxy; (4) C 2-10 alkenyl; (5) C 3-8 cycloalkyl; (6) substituted C 3-8 cycloalkyl in which one substituent is: (a) C 1-10 alkyl (b) substituted C 1-10 alkyl in which the substituent is selected from (i) halogen, (ii) hydroxy, (iii) C 1-10 alkoxy, (iv) C 1-5 alkoxycarbonyl, (v) C 1-5 acyloxy, (vi) phenyl, (vii) substituted phenyl in which the substituents are X and Y (viii) C 1-10 alkylS(O) n , (ix) C 3-8 cycloalkylS(O) n , (x) phenylS(O) n , (xi) substituted phenylS(O) n in which the substituents are X and Y, and (xii) oxo, (c) C 1-10 alkylS(O) n , (d) C 3-8 cycloalkylS(O) n , (e) phenylS(O) n , (f) substituted phenylS(O) n in which the substituents are X and Y, (g) halogen, (h) hydroxy, (i) C 1-10 alkoxy, (j) C 1-5 alkoxycarbonyl, (k) C 1-5 acyloxy, (l) phenyl, and (m) substituted phenyl in which the substituents are X and Y; (7) phenyl; (8) substituted phenyl in which the substituents are X and Y; (9) amino; (10) C 1-5 alkylamino; (11) di(C 1-5 alkyl)amino; (12) phenylamino; (13) substituted phenylamino in which the substituents are X and Y; (14) phenyl C 1-10 alkylamino; (15) substituted phenyl C 1-10 alkylamino in which the substituents are X and Y; and R 9 S in which R 9 is selected from (a) C 1-10 alkyl, (b) phenyl, and (c) substituted phenyl in which the substituents are X and Y; R 6 are independently: (1) hydrogen; (2) C 1-5 alkyl; (3) substituted C 1-5 alkyl in which the substituent is: (a) phenyl, (b) dimethylamino, and (c) acetylamino, and (4) 2,3-dihydroxypropyl; R 3 and R 4 are independently: (1) hydrogen; (2) C 1-10 alkyl; (3) substituted C 1-10 alkyl in which one or more substituent(s) is: (a) halogen, (b) hydroxy, (c) C 1-10 alkoxy, (d) C 1-5 alkoxycarbonyl, (e) C 1-5 acyloxy, (f) C 3-8 cycloalkyl, (g) phenyl, (h) substituted phenyl in which the substituents are X and Y, (i) C 1-10 alkylS(O) n , (j) C 3-8 cycloalkylS(O) n , (k) phenylS(O) n , (l) substituted phenylS(O) n in which the substituents are X and Y, and (m) oxo; (4) C 2-10 alkenyl; (5) substituted C 2-10 alkenyl in which one or more substituent(s) is: (a) halogen, (b) hydroxy, (c) C 1-10 alkoxy, (d) C 1-5 alkoxycarbonyl, (e) C 1-5 acyloxy, (f) C 3-8 cycloalkyl, (g) phenyl, (h) substituted phenyl in which the substituents are X and Y, (i) C 1-10 alkylS(O) n , (j) C 3-8 cycloalkylS(O) n , (k) phenylS(O) n , (l) substituted phenylS(O) n in which the substituents are X and Y, and (m) oxo; (6) C 3-8 cycloalkyl; (7) substituted C 3-8 cycloalkyl in which one substituent is: (a) C 1-10 alkyl (b) substituted C 1-10 alkyl in which the substituent is (i) halogen, (ii) hydroxy, (iii) C 1-10 alkoxy, (iv) C 1-5 alkoxycarbonyl, (v) C 1-5 acyloxy (vi) phenyl, (vii) substituted phenyl in which the substituents are X and Y (viii) C 1-10 alkylS(O) n , (ix) C 3-8 cycloalkylS(O) n , (x) phenylS(O) n in which the substituents are X and Y, and (xii) oxo, (c) C 1-10 alkylS(O) n , (d) C 3-8 cycloalkylS(O) n , (e) phenylS(O) n , (f) substituted phenylS(O) n in which the substituents are X and Y, (g) halogen, (h) hydroxy, (i) C 1-10 alkoxy, (j) C 1-5 alkoxycarbonyl, (k) C 1-5 acyloxy, (l) phenyl, and (m) substituted phenyl in which the substituents are X and Y; (8) phenyl; (9) substituted phenyl in which the substituents are X and Y; R 7 and R 8 are independently: (1) hydrogen; (2) C 1-10 alkyl; (3) substituted C 1-10 alkyl in which one or more substituent(s) is: (a) halogen, (b) hydroxy, (c) C 1-10 alkoxy, (d) C 1-10 alkoxycarbonyl, (e) C 1-5 acyloxy, (f) C 3-8 cycloalkyl, (g) phenyl, (h) substituted phenyl in which the substituents are X and Y, (i) C 1-10 alkyl S(O) n in which n is 0 to 2, (j) C 3-8 cycloalkyl S(O) n , (k) phenyl S(O) n ; (l) substituted phenyl S(O) n in which the substituents are X and Y, and (m) oxo; (4) C 2-10 alkenyl; (5) C 3-8 cycloalkyl; (6) aminocarbonyl; (7) substituted aminocarbonyl in which one or more substituent(s) is: (a) C 1-5 alkyl, (b) C 3-8 cycloalkyl, (c) phenyl, (d) substituted phenyl in which the substituents are X and Y; (8) phenyl; (9) substituted phenyl in which the substituents are X and Y; (10) C 1-10 alkylcarbonyl; (11) C 3-8 cycloalkylcarbonyl; (12) phenylcarbonyl; (13) substituted phenylcarbonyl in which the substituents are X and Y; and X and Y independently are hydrogen, halogen, trifluoromethyl, C 1-3 alkyl, nitro, cyano or a group selected from: (1) R 10 O (CH 2 ) m in which m is 0 to 3 and R 10 is hydrogen, C 2-3 alkyl or hydroxy C 2-3 alkyl; (2) ##STR51## in which R 11 is hydrogen, C 1-3 alkyl, hydroxy-C 2-3 alkyl, phenyl, naphthyl, amino C 1-3 alkyl, C 1-3 alkylamino-C 1-3 alkyl, di(C 1-3 alkyl)amino-C 1-3 alkyl, hydroxy C 2-3 alkylamino-C 1-3 alkyl or di(hydroxy C 2-3 alkyl) amino C 1-3 alkyl; (3) ##STR52## in which R 12 is hydrogen, C 1-3 alkyl, hydroxy-C 2-3 alkyl, C 1-3 alkoxy-C 1-3 alkyl, phenyl or naphthyl; (4) ##STR53## in which R 13 and R 14 independently are hydrogen, C 1-3 alkyl, and hydroxy-C 2-3 alkyl; (5) R 15 S(O) n (CH 2 )m in which R 15 is hydrogen, C 1-3 alkyl, amino, C 1-3 alkylamino or di(C 1-3 alkyl)amino; and a, b and c each represent single bonds or one of a, b and c represents a double bond or both a and c represent double bonds; or a pharmaceutically acceptable salt thereof.