US4994023A
Expired / Lapsed
US
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Electrochemical drug release and article
Assignee: Southwest Research Institute
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Filing: 1989-08-08
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Granted: 1991-02-19
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Expires: 2009-08-08
Abstract
Abstract An electrochemical drug release article containing an electrically conducting self-doped carbazole polymer of the formula: ##STR1## wherein A is a bifunctional molecule capable of bonding to a positively charged molecule at one end and is capable of bonding to a flexible spacer group Z at another end, Z is a flexible spacer group capable of bonding to an anionic group A at one end and is capable of bonding either to a nitrogen or aromatic electron withdrawing or electron donating group at another end, E is a bifunctional molecule capable of bonding to nitrogen at one end and is capable of bonding to a flexible spacer group Z at another end, X is a positively charged counterion, and n is at least 2.
Inventors
- 👤 Stephen T. Wellinghoff
- 👤 Charles K. Baker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 10:11
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/18; A61N1/20; A61N1/30; A61N1/303; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; A61K9/00; A61K9/0002; A61K9/0009
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
162 words
A drug delivery device comprising an electrically conducting self-doped carbozole polymer of the formula: ##STR4## wherein A is a bifunctional molecule capable of bonding to a positively charged molecule at one end and is capable of bonding to a flexible spacer group Z at another end, Z is a flexible spacer group capable of bonding to an anionic group A at one end and is capable of bonding to either to an aromatic nitrogen or electron withdrawing or electron donating group at another end, E is a bifunctional molecule capable of bonding to nitrogen at one end and is capable of bonding to a flexible spacer group Z at another end, X is a positively charged drug molecule, and n is at least 2, in the form of a film embedded in an electrolyte, a cathode and an anode operatively associated, respectively, with said polymer film and said electrolyte, and a source of electrical power operatively associated with said cathode and anode.
Claim 2
Dependent Claim
162 words
A drug delivery device comprising an electrically conducting self-doped carbozole polymer of the formula: ##STR4## wherein A is a bifunctional molecule capable of bonding to a positively charged molecule at one end and is capable of bonding to a flexible spacer group Z at another end, Z is a flexible spacer group capable of bonding to an anionic group A at one end and is capable of bonding to either to an aromatic nitrogen or electron withdrawing or electron donating group at another end, E is a bifunctional molecule capable of bonding to nitrogen at one end and is capable of bonding to a flexible spacer group Z at another end, X is a positively charged drug molecule, and n is at least 2, in the form of a film embedded in an electrolyte, a cathode and an anode operatively associated, respectively, with said polymer film and said electrolyte, and a source of electrical power operatively associated with said cathode and anode.
Claim 3
Dependent Claim
17 words
The device of claim 1 wherein the electrolyte is a biodegradable gel and said film is water-soluble.
Claim 4
Dependent Claim
16 words
The device of claim 1 or 2 wherein said source of electrical power is a battery.
Claim 5
Dependent Claim
11 words
The device of claim 1 wherein X is a cationic drug.
Claim 6
Dependent Claim
58 words
The device of claim 1 wherein A is a sulfonate or carboxylate, Z is a (--CH 2 --) n group with n equal to at least 1or a (--ROR--) group with R being a C 1 to C 4 alkylene group, E is a furan, pyrrole, thiophene, pyrimidine, or vinyl benzene group, and n is 2 to 100.
Claim 7
Dependent Claim
33 words
The drug of claim 1 or 5 wherein x is a hydrochloride of cocaine, cocaine derivative, barbituate, phenothiazene, atipyrine, morphine, codeine, analeptic, adrenergic blocker, cholinergic blocker, or tertiary ammonium salt of an anticholinergic.
References Cited (Backward Citations)
US222276A
Cited
US4211222A
Cited
US4352359A
Cited
US4416274A
Cited
US4820263A
Cited
US4474570A
Cited
US4747819A
Cited
US4842577A
Cited
US4731049A
Cited
US4860754A
Cited
US4840689A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-02-18 | 1994-08-20 | 1995-02-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-02-18 | 1998-08-20 | 1999-02-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-02-18 | 2002-08-20 | 2003-02-19 | $7700.00 | Window Closed / Lapsed |