Patent US4980403A successfully refreshed from Google Patents.
US4980403A
Expired / Lapsed
US
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Collagen products
Assignee: University of Melbourne
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Filing: 1987-01-02
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Granted: 1990-12-25
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Expires: 2007-01-02
Abstract
Abstract Collagen in tactoid form obtained by forming an aqueous solution containing dissolved collagen and a water soluble or miscible polymer adapted to precipitate collagen out of solution in the form of tactoids.
Inventors
- 👤 John F. Bateman
- 👤 John A. M. Ramshaw
- 👤 David E. Peters
- 👤 Peter A. Tulloch
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 20:53
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/24; C; C08; C08H; C08H1/00; C08H1/06; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/84; Y10S530/842
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
84 words
A method of producing a collagen product comprising forming an aqueous solution containing dissolved collagen, said solution having a pH of from about 3.5 to about 10, and adding a water soluble or miscible uncharged, neutral polymer to said solution in a concentration sufficient to cause precipitation of said collagen out of said solution in the form of tactoids, said method carried out at a temperature in the range of between the denaturation temperature of the collagen and the freezing point of the solution.
Claim 2
Independent Claim
84 words
A method of producing a collagen product comprising forming an aqueous solution containing dissolved collagen, said solution having a pH of from about 3.5 to about 10, and adding a water soluble or miscible uncharged, neutral polymer to said solution in a concentration sufficient to cause precipitation of said collagen out of said solution in the form of tactoids, said method carried out at a temperature in the range of between the denaturation temperature of the collagen and the freezing point of the solution.
Claim 3
Dependent Claim
20 words
A method of producing a collagen product as claimed in claim 1, wherein the pH of said solution is 7-8.
Claim 4
Dependent Claim
21 words
A method of producing a collagen product as claimed in claim 2, including forming the thus formed precipitate to a shape.
Claim 5
Dependent Claim
20 words
A method of producing a collagen product as claimed in claim 3, including precipitating the collagen onto a pre-shaped substrate.
Claim 6
Dependent Claim
22 words
A method of producing a collagen product as claimed in claim 4, wherein the substrate has the form of a body part.
Claim 7
Dependent Claim
25 words
A method of producing a collagen product as claimed in claim 4, wherein the substrate is itself formed of collagen in the form of tactoids.
Claim 8
Dependent Claim
38 words
A method of producing a collagen product as claimed in claim 3, wherein prior into forming said precipitate to a shape the precipitate is permitted to stand in said solution for a period of greater than 1 hour.
Claim 9
Dependent Claim
25 words
A method of producing a collagen product as claimed in claim 2 wherein the temperature of carrying out the method is from about 0° C.
Claim 10
Dependent Claim
25 words
A method of producing a collagen product as claimed in claim 1, and including the step of chemically or biochemically stabilizing the collagen so formed.
Claim 11
Dependent Claim
23 words
A method of producing a collagen product as claimed in claim 1, wherein the dissolved collagen is derived from cell or tissue culturing.
Claim 12
Dependent Claim
43 words
A method of producing a collagen product as claimed in claim 2, wherein said water soluble or miscible polymer is selected from the group consisting of polyvinyl alcohol, polyethylene oxide, polyvinylpyrrolidinone, polyacrylamide, polyethylene glycol, polypropylene glycol, polyvinyl methyl ether and maleic anhydride copolymers.
Claim 13
Dependent Claim
36 words
A method of producing a collagen product as claimed in claim 2, wherein said water soluble or miscible polymer is selected from the group consisting of hydroxyethyl starches, methyl-cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose and hydroxypropyl cellulose.
Claim 14
Dependent Claim
32 words
A method of producing a collagen product as claimed in claim 2, wherein said water soluble or miscible polymer is selected from the group consisting of agarose, dextrins, dextrans, starches and pectins.
Claim 15
Dependent Claim
18 words
A collagen product formed by the method of any one of claims 2, 8, 11, 12 or 13.
Claim 16
Dependent Claim
44 words
A collagen product as claimed in claim 14 in admixture with a biologically active material, selected from the group consisting essentially of proteoglycans, glycosaminoglycans, proteins, extracellular products, hormones, growth factors, antibiotics and wound-healing agents, insoluble collagen or a derivative thereof, and ionic strength modifiers.
Claim 17
Dependent Claim
17 words
A collagen product as claimed in claim 14 in the form of a sheet or a tube.
Claim 18
Dependent Claim
17 words
A collagen product as claimed in claim 14 in the form of a slurry or a paste.
Claim 19
Dependent Claim
21 words
A collagen product as claimed in claim 17 wherein said collagen is present in a concentration of at least 10 mgm/ml.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-12-24 | 1994-06-25 | 1994-12-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-12-24 | 1998-06-25 | 1998-12-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-12-24 | 2002-06-25 | 2002-12-25 | $7700.00 | Window Closed / Lapsed |