US4978391A — Intraoral medicament delivery and procedure

Claim 1

Independent Claim 182 words

A method for providing intraoral time released delivery of a medicament in the oral cavity comprising the steps of sequentially: (a) affixing a base to a tooth by applying a dental adhesive to a tooth and/or said base and then touching said base to said tooth, (b) applying a nontoxic prepolymer of a polyether, polyester, polyurethane, or mixtures thereof containing a medicament to said base said prepolymer comprising a compound of the general formula ##STR1## wherein R 1 may be the same or different R 3 is H, alkyl of 2-10 carbons, sub alkyl of 2-10 carbons, aryl of 6-14 carbon, sub aryl of 6-14 carbons, F, Cn and R 3 may be the same or different in each position; R 4 is a divalent hydrocarbon radical or divalent sub hydrocarbon radical and may be straight or branched chain or acyclic or a combination thereof from 2-10 carbons; and is a polyurethane, polyether or polyester backbone; polysiloxanedimethacrylate, and polyorganosilylene, and (c) polymerizing to affix the resulting polymeric material to said base and to produce a polymer which is elastomeric, soft and pliable.

Claim 2

Independent Claim 182 words

A method for providing intraoral time released delivery of a medicament in the oral cavity comprising the steps of sequentially: (a) affixing a base to a tooth by applying a dental adhesive to a tooth and/or said base and then touching said base to said tooth, (b) applying a nontoxic prepolymer of a polyether, polyester, polyurethane, or mixtures thereof containing a medicament to said base said prepolymer comprising a compound of the general formula ##STR1## wherein R 1 may be the same or different R 3 is H, alkyl of 2-10 carbons, sub alkyl of 2-10 carbons, aryl of 6-14 carbon, sub aryl of 6-14 carbons, F, Cn and R 3 may be the same or different in each position; R 4 is a divalent hydrocarbon radical or divalent sub hydrocarbon radical and may be straight or branched chain or acyclic or a combination thereof from 2-10 carbons; and is a polyurethane, polyether or polyester backbone; polysiloxanedimethacrylate, and polyorganosilylene, and (c) polymerizing to affix the resulting polymeric material to said base and to produce a polymer which is elastomeric, soft and pliable.

Claim 3

Dependent Claim 33 words

The method of claim 1 which further comprises the step of selecting said prepolymer to have properties such that said medicament is extracted from said polymeric material by saliva in the oral cavity.

Claim 4

Dependent Claim 26 words

The method of claim 1 which comprises the step of providing said base in the form of an orthodontic bracket which is used to straighten teeth.

Claim 5

Dependent Claim 19 words

The method of claim 1 which comprises the step of choosing said medicament for the purpose of treating dental.

Claim 6

Dependent Claim 38 words

The method of claim 4 which comprises the step of selecting said medicament from the group comprising antiseptics, germicides, antimicrobials, antibiotics, topical anaesthetics, antifungal agents, anti-inflammatory agents, antiviral agents, tooth desensitizing agents, wound healing agents and anti-collagenase agents.

Claim 7

Dependent Claim 33 words

The method of claim 1 which comprises the step of adding light activated initiators and accelerators to said prepolymer and adapting said prepolymer to be polymerized using light in the visible wavelength range.

Claim 8

Dependent Claim 16 words

The method of claim 6 which comprises the step of selecting said initiator to be camphorquinone.

Claim 9

Dependent Claim 20 words

The method of claim 1 comprising the step of affixing said base to said tooth after acid etching said tooth.

Claim 10

Independent Claim 180 words

A method for cushioning dental appliance in the oral cavity comprising the steps of sequentially: (a) affixing a dental appliance in the mouth by applying a dental adhesive to a tooth and/or said dental appliance and then touching said dental appliance to said tooth, (b) applying a nontoxic prepolymer of a polyether, polyester, polyurethane, or mixture thereof to said dental appliance said polymer comprising ##STR2## wherein R 1 may be the same or different R 3 is H, alkyl of 2-10 carbons, sub alkyl of 2-10 carbons, aryl of 6-14 carbon, sub aryl of 6-14 carbons F, CN and R 3 may be the same or different in each position; R 4 is a divalent hydrocarbon radical or divalent sub hydrocarbon radical and may be straight or branched chain or acyclic or a combination thereof from 2-10 carbons; and is a polyurethane, polyether or polyester backbone; polysiloxanedimethacrylate, and polyorganosilylene, and (c) polymerizing said prepolymer to produce an elastic polymer which is soft and pliable using light in the visible wavelength range to affix the resulting polymeric material to said base.

Claim 11

Independent Claim 180 words

A method for cushioning dental appliance in the oral cavity comprising the steps of sequentially: (a) affixing a dental appliance in the mouth by applying a dental adhesive to a tooth and/or said dental appliance and then touching said dental appliance to said tooth, (b) applying a nontoxic prepolymer of a polyether, polyester, polyurethane, or mixture thereof to said dental appliance said polymer comprising ##STR2## wherein R 1 may be the same or different R 3 is H, alkyl of 2-10 carbons, sub alkyl of 2-10 carbons, aryl of 6-14 carbon, sub aryl of 6-14 carbons F, CN and R 3 may be the same or different in each position; R 4 is a divalent hydrocarbon radical or divalent sub hydrocarbon radical and may be straight or branched chain or acyclic or a combination thereof from 2-10 carbons; and is a polyurethane, polyether or polyester backbone; polysiloxanedimethacrylate, and polyorganosilylene, and (c) polymerizing said prepolymer to produce an elastic polymer which is soft and pliable using light in the visible wavelength range to affix the resulting polymeric material to said base.

Claim 12

Dependent Claim 20 words

The method of claim 9 which comprises the step of using a prepolymer which produces a polymer having hydrophilic properties.

Claim 13

Dependent Claim 23 words

The method of claim 9 which comprises the step of including a medicament in said prepolymer for slow release into the oral cavity.

Claim 14

Independent Claim 157 words

An apparatus for intraoral time released delivery of a medicament in the oral cavity comprising: (a) a base comprising an orthodontic bracket adapted to be affixed to a tooth by adhering said base to said tooth using dental adhesive, and (b) a nontoxic polymeric material comprising polyether, polyester, polyurethane, or mixtures thereof containing a medicament affixed to said base, said polymer being elastic, soft and pliable said polymer comprising a crosslinked prepolymer comprising ##STR3## wherein R 1 may be the same or different R 3 is H, alkyl of 2-10 carbons, sub alkyl of 2-10 carbons, aryl of 6-14 carbon, subaryl of 6-14 carbons, F, CN and R 3 may be the same or different in each position; R 4 is a divalent hydrocarbon radical or divalent sub hydrocarbon radical and may be straight or branched chain or acyclic or a combination thereof from 2-10 carbons; and is a polyurethane, polyether or polyester backbone; polysiloxanedimethacrylate, and polyorganosilylene.

Claim 15

Independent Claim 157 words

An apparatus for intraoral time released delivery of a medicament in the oral cavity comprising: (a) a base comprising an orthodontic bracket adapted to be affixed to a tooth by adhering said base to said tooth using dental adhesive, and (b) a nontoxic polymeric material comprising polyether, polyester, polyurethane, or mixtures thereof containing a medicament affixed to said base, said polymer being elastic, soft and pliable said polymer comprising a crosslinked prepolymer comprising ##STR3## wherein R 1 may be the same or different R 3 is H, alkyl of 2-10 carbons, sub alkyl of 2-10 carbons, aryl of 6-14 carbon, subaryl of 6-14 carbons, F, CN and R 3 may be the same or different in each position; R 4 is a divalent hydrocarbon radical or divalent sub hydrocarbon radical and may be straight or branched chain or acyclic or a combination thereof from 2-10 carbons; and is a polyurethane, polyether or polyester backbone; polysiloxanedimethacrylate, and polyorganosilylene.

Claim 16

Dependent Claim 29 words

The apparatus according to claim 12 in which said polymeric material has properties such that said medicament is extracted from said polymeric material by saliva in the oral cavity.

Claim 17

Dependent Claim 42 words

The apparatus according to claim 12 in which said medicament is adapted to treat dental disease and is selected from the group comprising antiseptics, germicides, antimicrobials, antibiotics, antifungal agents, anti-inflammatory agents, antiviral agents, tooth desensitizing agents, wound healing agents and anti-collagenase agents.

Claim 18

Dependent Claim 17 words

The apparatus according to claim 12 in which said polymeric material is a light cured polymeric material.

Claim 19

Independent Claim 195 words

A method of cushioning a dental appliance in the oral cavity and producing intraoral time released delivery of a medicament to the oral cavity comprising the steps of sequentially: (a) affixing a dental appliance comprising orthodontic brackets to a plurality of teeth by applying a dental adhesive to said brackets and/or said teeth and then touching said brackets to said teeth, (b) applying a prepolymer of a polyether, polyester, polyurethane or a mixture thereof containing a medicament to said dental appliance said prepolymer comprising ##STR4## wherein R 1 may be the same or different R 3 is H, alkyl of 2-10 carbons, sub alkyl of 2-10 carbons, aryl of 6-14 carbon, sub aryl of 6-14 carbons, F, CN and R 3 may be the same or different in each position; R 4 is a divalent hydrocarbon radical or divalent sub hydrocarbon radical and may be straight or branched chain or acrylic or a combination thereof from 2-10 carbons; and is a polyurethane, polyether or polyester backbone; polysiloxanedimethacrylate, and polyorganosilylene, and (c) polyumerizing said prepolymer to form an elastic, soft, pliable polymer and to at least mechanically attach the resulting polymeric material to said dental appliance.

Claim 20

Independent Claim 195 words

A method of cushioning a dental appliance in the oral cavity and producing intraoral time released delivery of a medicament to the oral cavity comprising the steps of sequentially: (a) affixing a dental appliance comprising orthodontic brackets to a plurality of teeth by applying a dental adhesive to said brackets and/or said teeth and then touching said brackets to said teeth, (b) applying a prepolymer of a polyether, polyester, polyurethane or a mixture thereof containing a medicament to said dental appliance said prepolymer comprising ##STR4## wherein R 1 may be the same or different R 3 is H, alkyl of 2-10 carbons, sub alkyl of 2-10 carbons, aryl of 6-14 carbon, sub aryl of 6-14 carbons, F, CN and R 3 may be the same or different in each position; R 4 is a divalent hydrocarbon radical or divalent sub hydrocarbon radical and may be straight or branched chain or acrylic or a combination thereof from 2-10 carbons; and is a polyurethane, polyether or polyester backbone; polysiloxanedimethacrylate, and polyorganosilylene, and (c) polyumerizing said prepolymer to form an elastic, soft, pliable polymer and to at least mechanically attach the resulting polymeric material to said dental appliance.

Claim 21

Dependent Claim 33 words

The method of claim 16 which further comprises the step of selecting said prepolymer to have properties such that said medicament is extracted from said polymeric material by saliva in the oral cavity.

Claim 22

Dependent Claim 26 words

The method of claim 16 which comprises the step of providing said base in the form of an orthodonic bracket which is used to straighten teeth.

Claim 23

Independent Claim 20 words

The method of claim -6 which comprises the step of choosing said medicament for the purpose of treating dental disease.

Claim 24

Dependent Claim 17 words

The method of claim 19 which comprises using a medicament which is a source of fluoride ions.

Claim 25

Dependent Claim 28 words

The method of claim 1 wherein said prepolymer is selected from the group consisting of -polydimethyl-silylene-co-phenylmethylsilylene, polycarbonate urethane dimethacrylates, ethoxylated bisphenol A dimethacrylate, 2,2-Bis-propane (BISGMA), and 2,2-Bis-propane (BISIPMA).

Claim 26

Independent Claim 85 words

A method for providing intraoral time released delivery of a medicament in the oral cavity comprising the steps of sequentially: (a) affixing a base to a tooth by applying a dental adhesive to a tooth and/or said base and then touching said base to a tooth (b) applying a non-toxic prepolymer of a polyether, polyester, polyurethane, or mixtures thereof containing a medicament to said base, and (c) polymerizing the prepolymer to affix the resulting polymeric material to said base and to produce an elastomeric polymer.

Claim 27

Independent Claim 85 words

A method for providing intraoral time released delivery of a medicament in the oral cavity comprising the steps of sequentially: (a) affixing a base to a tooth by applying a dental adhesive to a tooth and/or said base and then touching said base to a tooth (b) applying a non-toxic prepolymer of a polyether, polyester, polyurethane, or mixtures thereof containing a medicament to said base, and (c) polymerizing the prepolymer to affix the resulting polymeric material to said base and to produce an elastomeric polymer.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1993-12-17	1994-06-18	1994-12-18	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1997-12-17	1998-06-18	1998-12-18	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2001-12-17	2002-06-18	2002-12-18	$7700.00	Window Closed / Lapsed

Intraoral medicament delivery and procedure

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