US4978332A
Expired / Lapsed
US
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Treatments employing vasoconstrictive substances in combination with cytotoxic agents for introduction into cellular lesion areas
Assignee: Intarcia Therapeutics Inc
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Filing: 1987-09-28
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Granted: 1990-12-18
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Expires: 2007-09-28
Abstract
Abstract A pharmaceutical composition and method of treating cellular disorders involving abnormal solid cellular growths which comprises administering a pharmaceutical composition containing cytotoxic agents in combination with a vasoconstrictive drug. Enhanced effectiveness of the composition is observed, with reduced cytotoxic effects on cells distant from the site of introduction. Agents may be included to enhance therapeutic gain and reduce adverse affects to normal tissue.
Inventors
- 👤 Edward E. Luck
- 👤 Dennis M. Brown
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:37
CPC Classifications
A; A61; A61K; A61K45/00; A61K45/06; A61K33/00; A61K33/24; A61K33/243; A61P; A61P35/00
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
65 words
A method for treating a neoplastic lesion or surrounding tissue which comprises: applying at the site of said length a composition consisting essentially of a uniformly dispersed vasconstrictive drug and at least one uniformly dispersed cytotoxic drug in a non-proteinaceous aqueous medium; whereby said drug is retained in the immediate environment avoiding significant levels of the drug at sites distant from the site of introduction.
Claim 2
Independent Claim
65 words
A method for treating a neoplastic lesion or surrounding tissue which comprises: applying at the site of said length a composition consisting essentially of a uniformly dispersed vasconstrictive drug and at least one uniformly dispersed cytotoxic drug in a non-proteinaceous aqueous medium; whereby said drug is retained in the immediate environment avoiding significant levels of the drug at sites distant from the site of introduction.
Claim 3
Dependent Claim
49 words
A method according to claim 1, wherein said vasoconstrictive drug is at least one of the following: epinephrine, norepinephrine, the catecholamines, epinephrine isoproterenol, dopamine, ephedrine, phenylephrine, amphetamine, metraminol, methoxamine, ergot alkaloids, ergonovine, methylergonavine, methysergide, ergotamine, an angiotensin, and a prostaglandin: said vasoconstrictive drug present in a therapeutically effective amount.
Claim 4
Dependent Claim
34 words
A method according to claim 1, wherein said cytotoxic drug is at least one of the following: an alkylating agent, enzyme inhibitor, lytic agent, DNA synthesis inhibitor, membrane permeability modifier, DNA intercalator, or antimetabolite.
Claim 5
Dependent Claim
56 words
A method according to claim 1, wherein said cytotoxic drug is at least one of the following: cisplatin, doxorubicin hydrochloride, bleomycin sulfate, fluorouracil, vincristine sulfate, vinblastine sulfate, chlorambucil, melphalan, busulfan, carmustine, lomustine, streptozotocin, thiotepa, dacarbazine, methotrexate, cytarabine, azaribine, mercaptopurine, thioguanine, actinomycin D, plicamycin, mitomycin-C, asparaginase, procarbazine hydrochloride, prednisone, prednisi iamcinolone, testosterone, estrogen, insulin, BUdR nitrosourea, hydroxyurea.
Claim 6
Dependent Claim
25 words
A method according to claim 1, wherein said composition in addition consists of an agent affecting tissue architecture and present in a therapeutically effective amount.
Claim 7
Dependent Claim
24 words
A method according to claim 5, wherein said agent affecting tissue architecture is at least one of papain, chymopapain, trypsin, amylase, collagenase and chymotrypsin.
Claim 8
Dependent Claim
25 words
A method according to claim 1, wherein said composition in addition consists of an agent affecting cellular permeability and present in a therapeutically effective amount.
Claim 9
Dependent Claim
22 words
A method according to claim 7, wherein said agent affecting cellular permeability is at least one of detergents, amphotericin B and dimethylsulfoxide.
Claim 10
Dependent Claim
34 words
A method according to claim 1, wherein an affecting cytotoxic activity which is at least one of radionuclides technicium or iridium, misonidazole and cytokines is present in said medium in a therapeutically effective amount.
Claim 11
Dependent Claim
25 words
A method according to claim 1, comprising the additional step of treating said lesion site with radiation or heat applied in a therapeutically effective amount.
Claim 12
Dependent Claim
19 words
A pharmaceutical composition consisting essentially of a vasoconstrictive drug, a cytotoxic drug and a protein-free aqueous pharmacologically acceptable vehicle.
Claim 13
Dependent Claim
19 words
A pharmaceutical composition consisting essentially of a vasoconstrictive drug, a cytotoxic drug and a protein-free aqueous pharmacologically acceptable vehicle.
Claim 14
Dependent Claim
44 words
A pharmaceutical composition according to claim 11, wherein said vasoconstrictive drug is at least one of the following: epinephrine, norepinephrine, the catecholamines, epinephrine isoproterenol, dopamine, ephedrine and other phenylisopropylamines, phenylephrine, amphetamine, metraminol, methoxamine, ergot alkaloids, ergonovine, methylergonavine, methysergide, ergotamine, the angiotensins and the prostaglandins.
Claim 15
Dependent Claim
32 words
A pharmaceutical composition according to claim 11, wherein said cytotoxic drug is at least one of the following: an alkylating agent, enzyme inhibitor, lytic agent, DNA synthesis inhibitor, DNA intercalator, or antimetabolite.
Claim 16
Dependent Claim
60 words
A pharmaceutical composition according to claim 11, wherein said cytotoxic drug is at least one of the following: cisplatin, doxorubicin hydrochloride, bleomycin sulfate, fluorouracil, vincristine sulfate, vinblastine sulfate, chlorambucil, melphalan, busulfan carmustine, lomustine, streptozotocin, thiotepa, dacarbazine, methotrexate, cytarabine, azaribine, mercaptopurine, thioguanine, actinomycin D, plicamycin, mitomycin-C, asparaginase, procarbazine hydrochloride, prednisone, prednisilone, triamcinolone, testosterone, estrogen, insulin, BUdR, nitrosourea, carmustine, lomustine, and hydroxyurea.
Claim 17
Dependent Claim
23 words
A pharmaceutical composition according to claim 11, in addition consisting of an agent affecting tissue architecture and present in a therapeutically effective amount.
Claim 18
Dependent Claim
25 words
A pharmaceutical composition according to claim 15, wherein said agent affecting tissue architecture is at least one of papain, chymopapain, trypsin, amylase, collagenase and chymotrypsin.
Claim 19
Dependent Claim
23 words
A pharmaceutical composition according to claim 11, in addition consisting of an agent affecting cellular permeability and present in a therapeutically effective amount.
Claim 20
Dependent Claim
23 words
A pharmaceutical composition according to claim 17, wherein said agent affecting cellular permeability is at least one of detergents, amphotericin B and dimethylsulfoxide.
Claim 21
Dependent Claim
24 words
A pharmaceutical composition according to claim 11, in addition consisting of an agent affecting said cytotoxic activity and present in a therapeutically effective amount.
Claim 22
Dependent Claim
25 words
A pharmaceutical composition according to claim 19, wherein said agent affecting cytotoxic activity is at least one of radionuclides technicium or iridium, nitroimidazoles, and cytokines.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-12-17 | 1994-06-18 | 1994-12-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-12-17 | 1998-06-18 | 1998-12-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-12-17 | 2002-06-18 | 2002-12-18 | $7700.00 | Window Closed / Lapsed |