US4971799A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Percutaneous-administration-type pharmaceutical preparation of nitroglycerin
Assignee: NOF Corp
•
Filing: 1988-03-31
•
Granted: 1990-11-20
•
Expires: 2008-03-31
Abstract
Abstract A percutaneous-administration-type pharmaceutical preparation of nitroglycerin comprising a backing that is impervious to medicines, and a pressure-sensitive adhesive layer that is disposed on one surface of the backing, wherein the pressure-sensitive adhesive layer contains alkyl (meth)acrylate copolymer in the concentration of 80-95% by weight and the nitroglycerin in the concentration of 5-20% by weight, said copolymer contains as major copolymer components alkyl (meth)acrylate with alkyl groups having 6 or more carbon atoms, which alkyl (meth)acrylates include 2-ethylhexylmethacrylate in the concentration of 40-90% by weight based on the total weight of said alkyl (meth)acrylates, and the copolymer has a rolling ball tack value of 2 or less. The preparation obtained makes it possible for nitroglycerin to be absorbed percutaneously at a controlled rate for long periods of time.
Inventors
- 👤 Takashi Nakagawa
- 👤 Masayasu Kurono
- 👤 Makoto Sato
- 👤 Tsutomu Ishida
- 👤 Kazushi Tokita
- 👤 Katsuhiko Takahashi
- 👤 Masato Azuma
- 👤 Satoshi Uenoyama
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 00:04
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7038; A61K9/7046; A61K9/7053; A61K9/7061; A61K31/00; A61K31/21; A61K9/7076; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/58; A61P; A61P9/00; A61P9/08; A61P9/10
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
111 words
A percutaneous pharmaceutical preparation of nitroglycerin comprising a backing that is impervious to medicines, and a pressure-sensitive adhesive layer that is disposed on one surface of said backing, wherein said pressure-sensitive adhesive layer contains alkyl (meth)acrylate copolymer in the concentration of 80-95% by weight and nitroglycerin in the concentration of 5-20% by weight, said copolymer contains as copolymer components 2-ethylhexylmethacrylate in the concentration of 40-90% by weight and alkyl (meth)acrylates with alkyl groups having 6 or more carbon atoms in the concentration of 60-10% by weight based on the total weight of said 2-ethylhexylmethacrylate and said alkyl (meth)acrylates, and said copolymer has a rolling ball tack value of 2 or less.
Claim 2
Dependent Claim
111 words
A percutaneous pharmaceutical preparation of nitroglycerin comprising a backing that is impervious to medicines, and a pressure-sensitive adhesive layer that is disposed on one surface of said backing, wherein said pressure-sensitive adhesive layer contains alkyl (meth)acrylate copolymer in the concentration of 80-95% by weight and nitroglycerin in the concentration of 5-20% by weight, said copolymer contains as copolymer components 2-ethylhexylmethacrylate in the concentration of 40-90% by weight and alkyl (meth)acrylates with alkyl groups having 6 or more carbon atoms in the concentration of 60-10% by weight based on the total weight of said 2-ethylhexylmethacrylate and said alkyl (meth)acrylates, and said copolymer has a rolling ball tack value of 2 or less.
Claim 3
Dependent Claim
39 words
A percutaneous pharmaceutical preparation of nitroglycerin according to claim 1, wherein said alkyl (meth)acrylate copolymer contains poly-functional monomers as copolymer components in the concentration of 0.001-0.1% by weight based on the total weight of all monomers of said copolymer.
Claim 4
Dependent Claim
35 words
A percutaneous pharmaceutical preparation of nitroglycerin according to claim 1, wherein said pressure-sensitive adhesive layer contains said (meth)acrylate copolymer in the concentration of 80-90% by weight and nitroglycerin in the concentration of 10-20% by weight.
Claim 5
Independent Claim
136 words
A method for the manufacture of percutaneous pharmaceutical preparations of nitroglycerin comprising: applying an organic-solvent solution that contains alkyl (meth)acrylate copolymer and nitroglycerin to one surface of a backing that is impervious to medicines; and drying said coated layer on the backing, resulting in a pressure-sensitive adhesive layer, wherein said copolymer contains 2-ethylhexylmethacrylate in the concentration of 40-90% by weight and alkyl (meth)acrylates with alkyl groups having 6 or more carbon atoms in the concentration of 60-10% by weight based on the total weight of said 2-ethylhexylmethacrylate and said alkyl (meth)acrylates, and has a rolling ball tack value of 2 or less, said organic solvent has a solubility parameter of 8.9-9.9, and said pressure-sensitive adhesive layer contains said copolymer in the concentration of 80-95% by weight and said nitroglycerin in the concentration of 5-20% by weight.
Claim 6
Independent Claim
136 words
A method for the manufacture of percutaneous pharmaceutical preparations of nitroglycerin comprising: applying an organic-solvent solution that contains alkyl (meth)acrylate copolymer and nitroglycerin to one surface of a backing that is impervious to medicines; and drying said coated layer on the backing, resulting in a pressure-sensitive adhesive layer, wherein said copolymer contains 2-ethylhexylmethacrylate in the concentration of 40-90% by weight and alkyl (meth)acrylates with alkyl groups having 6 or more carbon atoms in the concentration of 60-10% by weight based on the total weight of said 2-ethylhexylmethacrylate and said alkyl (meth)acrylates, and has a rolling ball tack value of 2 or less, said organic solvent has a solubility parameter of 8.9-9.9, and said pressure-sensitive adhesive layer contains said copolymer in the concentration of 80-95% by weight and said nitroglycerin in the concentration of 5-20% by weight.
Claim 7
Dependent Claim
44 words
A method for the manufacture of percutaneous pharmaceutical preparations of nitroglycerin according to claim 4, wherein said alkyl (meth)acrylate copolymer contains poly-functional monomers as copolymer components in the concentration of 0.001-0.1% by weight based on the total weight of all monomers of said copolymer.
Claim 8
Dependent Claim
40 words
A method for the manufacture of percutaneous pharmaceutical preparations of nitroglycerin according to claim 4, wherein said pressure-sensitive adhesive layer contains said (meth)acrylate copolymer in the concentration of 80-90% by weight and nitroglycerin in the concentration of 10-20% by weight.
References Cited (Backward Citations)
JPS5416566A
Cited
JPS552604A
Cited
US4466953A
Cited
US4291015A
Cited
US4470962A
Cited
US4286592A
Cited
EP0035399A2
Cited
US4421737A
Cited
US4336243A
Cited
JPS5756424A
Cited
EP0062682A1
Cited
US4505891A
Cited
JPS5775917A
Cited
JPS5867776A
Cited
JPS58177913A
Cited
US4608249A
Cited
US4769028A
Cited
EP0156080A1
Cited
EP0181970A1
Cited
WO1986006281A1
Cited
US4751087A
Cited
US4751087B1
Cited
US4615699A
Cited
US4814168A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-11-19 | 1994-05-21 | 1994-11-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-11-19 | 1998-05-21 | 1998-11-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-11-19 | 2002-05-21 | 2002-11-20 | $7700.00 | Window Closed / Lapsed |