US4608249A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hydrophilic therapeutic material
Assignee: Toa Eiyo Ltd
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Filing: 1982-11-02
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Granted: 1986-08-26
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Expires: 2002-11-02
Abstract
Abstract A hydrophilic therapeutic material comprising a carrier and a drug-containing patching layer formed thereon directly or indirectly, wherein said patching layer comprises a copolymer of 5 to 75% by weight of an acrylic or methacrylic ester having an ether group in the molecule, 85 to 15% by weight of an alkyl acrylate or alkyl methacrylate and 10 to 50% by weight of a polar monomer copolymerizable therewith.
Inventors
- 👤 Saburo Otsuka
- 👤 Toshiyuki Yoshikawa
- 👤 Shoichi Tokuda
- 👤 Yuusuke Ito
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 12:57
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7038; A61K9/7046; A61K9/7053; A61K9/7061
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
90 words
A hydrophilic therapeutic material comprising a backing and a drug-containing patching layer formed thereon directly or indirectly, wherein said patching layer comprises a copolymer of 5 to 75% by weight of an acrylic or methacrylic ester having an ether group in the molecule and having a glass transition temperature of from -10° C. to -70° C., 85 to 15% by weight of an alkyl acrylate or alkyl methacrylate, each alkyl group having from 4 to 13 carbon atoms, and 10 to 50% by weight of a functional monomer copolymerizable therewith.
Claim 2
Dependent Claim
90 words
A hydrophilic therapeutic material comprising a backing and a drug-containing patching layer formed thereon directly or indirectly, wherein said patching layer comprises a copolymer of 5 to 75% by weight of an acrylic or methacrylic ester having an ether group in the molecule and having a glass transition temperature of from -10° C. to -70° C., 85 to 15% by weight of an alkyl acrylate or alkyl methacrylate, each alkyl group having from 4 to 13 carbon atoms, and 10 to 50% by weight of a functional monomer copolymerizable therewith.
Claim 3
Dependent Claim
40 words
A hydrophilic therapeutic material as in claim 1, wherein said backing is selected from the group consisting of a synthetic resin film, a sheet of paper, a non-woven fabric, a woven fabric, a knitted fabric, and a soft metal foil.
Claim 4
Dependent Claim
30 words
A hydrophilic therapeutic material as in claim 1, wherein said drug-containing patching layer is applied to a lesion of the skin indirectly with the aid of an auxiliary adhesive means.
Claim 5
Dependent Claim
16 words
A hydrophilic therapeutic material as in claim 3, wherein said auxiliary means is surgical adhesive tape.
Claim 6
Dependent Claim
68 words
A hydrophilic therapeutic material as in claim 1, wherein said ether substituted acrylate or methacrylate ester is selected from the group consisting of tetrahydrofurfuryl acrylate, tetrahydrofurfuryl methacrylate, methoxypolyethylene glycol acrylate, methoxypolyethylene glycol methacrylate, ethoxydiethylene glycol acrylate, ethoxydiethylene glycol methacrylate, butoxydiethylene glycol acrylate, butoxydiethylene glycol methacrylate, butylene glycol acrylate, butylene glycol methacrylate, methoxyethyl acrylate, methoxyethyl methacrylate, 3-ethoxypropyl acrylate, 3-ethoxypropyl methacrylate, ethoxyethyl acrylate, ethoxyethyl methacrylate, butoxyethyl acrylate and butoxyethyl methacrylate.
Claim 7
Dependent Claim
55 words
A hydrophilic therapeutic material as in claim 1, wherein said alkyl acrylate or alkyl methacrylate is selected from the group consisting of nbutyl acrylate, n-butyl methacrylate, hexyl acrylate, hexyl methacrylate, 2-ethylbutyl acrylate, 2-ethylbutyl methacrylate, isooctyl acrylate, isooctyl methacrylate, 2-ethylhexyl acrylate, 2-ethylhexyl methacrylate, decyl acrylate, decyl methacrylate, dodecyl acrylate, dodecyl methacrylate, tridecyl acrylate and tridecyl methacrylate.
Claim 8
Dependent Claim
47 words
A hydrophilic therapeutic material as in claim 1, wherein the functional monomer is selected from the group consisting of acrylic acid, methacrylic acid, itaconic acid, maleic acid, maleic anhydride, hydroxyethyl acrylate, hydroxypropyl acrylate, acrylamide, dimethyl acrylamide and vinyl ester such as acrylonitrile, vinyl acetate and vinyl propionate.
Claim 9
Dependent Claim
25 words
A hydrophilic therapeutic material as in claim 7, wherein said vinyl ester is selected from the group consisting of acrylonitrile, vinyl acetate and vinyl propionate.
Claim 10
Dependent Claim
28 words
A hydrophilic therapeutic material as in claim 1, comprising 0.5 to 20 parts by weight of a pharmaceutically acceptable adjuvant, per 100 parts by weight of said copolymer.
Claim 11
Dependent Claim
41 words
A hydrophilic therapeutic material as in claim 9, wherein the adjuvant is at least one member selected from the group consisting of propylene glycol, diethylene glycol, salicylic acid, urea, allantoin, dimethyl sulfoxide, dimethylacetamide, dimethylformamide, diisopropyl adipate, diethyl sebacate and ethyl laurate.
Claim 12
Dependent Claim
54 words
A hydrophilic therapeutic material as in claim 1, wherein the drug contained in the patching layer is at least one member selected from the group consisting of corticosteroids, analgesics, antiinflammatory agents, hypnotic agents, sedative agents, tranquilizers, antihypertensive agents, hypotensive diuretics, antibiotics, anesthetics, antimicrobial agents, antimycotic agents, vitamin preparations, anticonvulsants, coronary vasodilators and antihistaminic agents.
Claim 13
Dependent Claim
32 words
A hydrophilic therapeutic material as in claim 1, wherein the drug contained in the patching layer is at least one member selected from the group consisting of corticosteroids, analgesics and anti-inflammatory agents.
Claim 14
Dependent Claim
41 words
A hydrophilic therapeutic material as in claim 1, wherein the drug contained in the patching layer is in an amount of 0.01 to 20 parts by weight per 100 parts by weight of all of the components of the patching layer.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-08-25 | 1990-02-24 | 1990-08-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-08-25 | 1994-02-24 | 1994-08-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-08-25 | 1998-02-24 | 1998-08-26 | $7700.00 | Window Closed / Lapsed |