US4390520A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antiphlogistic analgesic adhesive
Assignee: Kawa Co Ltd
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Filing: 1981-03-30
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Granted: 1983-06-28
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Expires: 2001-03-30
Abstract
Abstract An antiphlogistic analgesic adhesive which comprises a flexible substrate and an indomethacin containing pressure-sensitive adhesive layer closely contacting said flexible substrate, wherein said pressure-sensitive adhesive layer comprises a mixture of (a) indomethacin, (b) a copolymer of (i) an alkyl acrylate having 4 to 11 carbon atoms in the alkyl moiety and (ii) a functional monomer having a functional group in the molecule thereof and/or a vinyl monomer, which has pressure-sensitive adhesive properties at room temperature, and (c) an absorption accelerating assistant which maintains said indomethacin in a solubilized state in said copolymer and has skin diffusibility.
Inventors
- 👤 Hidetaka Nagai
- 👤 Yasushi Wada
- 👤 Ichiro Kobayashi
- 👤 Mitsuru Tamada
- 👤 Keiichi Ushiyama
- 👤 Toshiyuki Yamamoto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 15:23
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7038; A61K9/7046; A61K9/7053; A61K9/7061; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/58
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
135 words
An antiphlogistic analgesic adhesive which comprises a flexible polymer substrate and an indomethacin containing pressure-sensitive adhesive layer closely contacting said flexible substrate, wherein said pressure-sensitive adhesive layer comprises a mixture of (a) indomethacin in an amount of about 5-100 mg per gram of a copolymer, where the copolymer is, (b) a copolymer of (i) an alkyl acrylate having 4 to 11 carbon atoms in the alkyl moiety and (ii) a functional monomer having a functional group in the molecule thereof and/or a vinyl monomer, which has pressure-sensitive adhesive properties at room temperature, said copolymer having an average molecular weight of about 20,000 to 500,000, and (c) an absorption accelerating assistant consisting of an aliphatic acid ester and polyoxyethylene glycol polyhydric alcohols, which has a solubility parameter (SP) of 11 or less and has skin diffusibility.
Claim 2
Dependent Claim
135 words
An antiphlogistic analgesic adhesive which comprises a flexible polymer substrate and an indomethacin containing pressure-sensitive adhesive layer closely contacting said flexible substrate, wherein said pressure-sensitive adhesive layer comprises a mixture of (a) indomethacin in an amount of about 5-100 mg per gram of a copolymer, where the copolymer is, (b) a copolymer of (i) an alkyl acrylate having 4 to 11 carbon atoms in the alkyl moiety and (ii) a functional monomer having a functional group in the molecule thereof and/or a vinyl monomer, which has pressure-sensitive adhesive properties at room temperature, said copolymer having an average molecular weight of about 20,000 to 500,000, and (c) an absorption accelerating assistant consisting of an aliphatic acid ester and polyoxyethylene glycol polyhydric alcohols, which has a solubility parameter (SP) of 11 or less and has skin diffusibility.
Claim 3
Dependent Claim
39 words
The antiphlogistic analgesic adhesive according to claim 1, wherein the alkyl acrylate is at least one alkyl acrylate selected from the group consisting of amyl acrylate, butyl acrylate, hexyl acrylate, heptyl acrylate, octyl acrylate, nonyl acrylate and 2-ethylhexyl acrylate.
Claim 4
Dependent Claim
20 words
The antiphlogistic analgesic adhesive according to claim 1, wherein the functional monomer is a monomer which has a carboxyl group.
Claim 5
Dependent Claim
39 words
The antiphlogistic analgesic adhesive according to claim 3, wherein the functional monomer having a carboxyl group is at least one monomer selected from the group consisting of acrylic acid, methacrylic acid, itaconic acid, maleic acid anhydride and crotonic acid.
Claim 6
Dependent Claim
20 words
The antiphlogistic analgesic adhesive according to claim 1, wherein the functional monomer is a monomer which has a hydroxyl group.
Claim 7
Dependent Claim
52 words
The antiphlogistic analgesic adhesive according to claim 5, wherein the functional monomer having a hydroxyl group is at least one monomer selected from the group consisting of hydroxymethyl acrylate, hydroxymethyl methacrylate, hydroxyethyl acrylate, hydroxyethyl methacrylate, hydroxypropyl acrylate, hydroxypropyl methacrylate, hydroxybutyl acrylate, hydroxybutyl methacrylate, hydroxyamyl acrylate, hydroxyamyl methacrylate, hydroxyhexyl acrylate and hydroxyhexyl methacrylate.
Claim 8
Dependent Claim
15 words
The antiphlogistic analgesic adhesive according to claim 1, wherein the vinyl monomer is vinyl actetate.
Claim 9
Dependent Claim
26 words
The antiphlogistic analgesic adhesive according to claim 1, wherein the amount of the functional monomer in the copolymer is about 0.1 to about 20% by weight.
Claim 10
Dependent Claim
26 words
The antiphlogistic analgesic adhesive according to claim 1, wherein the amount of the vinyl monomer in the copolymer is about 1 to about 50% by weight.
Claim 11
Dependent Claim
26 words
The antiphlogistic analgesic adhesive according to claim 1, wherein the difference in the solubility parameter between indomethacin and the absorption accelerating assistant is 2 or less.
Claim 12
Dependent Claim
35 words
The antiphlogistic analgesic adhesive according to claim 1, wherein the aliphatic acid ester is at least one aliphatic acid ester selected from the group consisting of adipic esters, sebacic acid esters and caproic acid esters.
Claim 13
Dependent Claim
18 words
The antiphlogistic analgesic adhesive according to claim 1, wherein the absorption accelerating assistant is polyoxyethylene glycol polyhydric alcohols.
Claim 14
Dependent Claim
31 words
The antiphlogistic analgesic adhesive according to any of claims 1, 8, or 12, wherein the weight ratio of the copolymer to the absorption accelerating assistant is about 1:0.01 to about 1:0.3.
References Cited (Backward Citations)
US3632740A
Cited
US3731683A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-06-27 | 1986-12-27 | 1987-06-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-06-27 | 1990-12-27 | 1991-06-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-06-27 | 1994-12-27 | 1995-06-28 | $7700.00 | Window Closed / Lapsed |