US4336243A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Transdermal nitroglycerin pad
Assignee: GD Searle LLC
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Filing: 1981-05-04
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Granted: 1982-06-22
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Expires: 2001-05-04
Abstract
Abstract The present invention provides a trans-dermal delivery pad for nitroglycerin administration, specifically a microsealed, trans-dermal nitroglycerin pad having a backing which is impervious to nitroglycerin absorption and transport and a silicon matrix affixed thereto, said silicone polymer matrix being of cross-linked silicone rubber having from about 10 to 200 micron microsealed compartments being formed by in situ cross-linking of the silicone rubber after it is mixed with a hydrophilic solvent system containing the nitroglycerin and a hydrophobic solvent which enhances nitroglycerin dispersion and transport.
Inventors
- 👤 Dilip R. Sanvordeker
- 👤 James G. Cooney
- 👤 Ronald C. Wester
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:21
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7038; A61K9/7046; A61K9/7069; A61K31/00; A61K31/21; A61K9/7092
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
122 words
A microsealed, nitroglycerin pad suitable for transdermal administration of nitroglycerin comprising a backing, a biologically acceptable silicone polymer matrix affixed to said backing, said silicone polymer matrix being of cross-linked silicone rubber having a plurality of 10 to 200 micron microsealed compartments therein, and containing therein from 10 to 30 volume percent of an aqueous hydrophilic solvent system comprising from about 6 to 22 weight percent of a mixture containing 10 weight percent nitroglycerin mixed with lactose therein, and from 5 to 15 weight percent of a hydrophobic solvent system, said hydrophobic solvent system being selected from the group consisting of mineral oil, a triglyceride of a saturated coconut oil acid and mixtures thereof, and said hydrophilic solvent being a polyethylene glycol.
Claim 2
Dependent Claim
122 words
A microsealed, nitroglycerin pad suitable for transdermal administration of nitroglycerin comprising a backing, a biologically acceptable silicone polymer matrix affixed to said backing, said silicone polymer matrix being of cross-linked silicone rubber having a plurality of 10 to 200 micron microsealed compartments therein, and containing therein from 10 to 30 volume percent of an aqueous hydrophilic solvent system comprising from about 6 to 22 weight percent of a mixture containing 10 weight percent nitroglycerin mixed with lactose therein, and from 5 to 15 weight percent of a hydrophobic solvent system, said hydrophobic solvent system being selected from the group consisting of mineral oil, a triglyceride of a saturated coconut oil acid and mixtures thereof, and said hydrophilic solvent being a polyethylene glycol.
Claim 3
Dependent Claim
18 words
The nitroglycerin pad of claim 1 wherein said hydrophilic solvent system is an aqueous polyethylene glycol 400 solution.
Claim 4
Dependent Claim
13 words
The nitroglycerin pad of claim 2 wherein said hydrophobic solvent is isopropyl palmitate.
Claim 5
Dependent Claim
13 words
The nitroglycerin pad of claim 2 wherein said hydrophobic solvent is mineral oil.
Claim 6
Dependent Claim
16 words
The nitroglycerin pad of claim 2 wherein said hydrophobic solvent compriese isopropyl palmitate and mineral oil.
Claim 7
Dependent Claim
16 words
The nitroglycerin pad of claim 2 wherein said hydrophobic solvent is mineral oil and migloyl oil.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-06-21 | 1985-12-21 | 1986-06-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-06-21 | 1989-12-21 | 1990-06-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-06-21 | 1993-12-21 | 1994-06-22 | $7700.00 | Window Closed / Lapsed |