Transdermal nitroglycerin delivery system

Claim 2

An adhesive-coated sheet material comprising: (a) a flexible backing; and (b) a pressure-sensitive adhesive-coating comprising a homogeneous mixture of: (i) an acrylic polymer comprising, as a major constituent, a hydrophobic monomeric acrylic or methacrylic acid ester of an alkyl alcohol, the alkyl alcohol containing 4 to 10 carbon atoms; and (ii) nitroglycerin in an amount by weight of about 25 to 45 percent of the total weight of said adhesive coating; said sheet material being suitable for substantially continuous transdermal delivery of nitroglycerin to a subject over a prolonged period in an amount which is therapeutically effective for prophylactically treating angina pectoris and/or controlling hypertension and/or treating congestive heart failure.

Claim 3

A method of treating angina and/or controlling hypertension and/or treating congestive heart failure wherein an adhesive-coated sheet material according to claim 1 is applied and adhered to the skin of a mammal.

Claim 4

A process for preparing the adhesive-coated sheet material of claim 1, comprising the steps of: (a) forming a homogeneous mixture comprising nitroglycerin and said acrylic polymer, said nitroglycerin being present in said mixture in an amount sufficient so that said pressure-sensitive adhesive coating of said adhesive-coated sheet material comprises nitroglycerin in an amount by weight of about 25 to 45 percent of the total weight of said pressure-sensitive adhesive coating; (b) wet-casting or coating the homogeneous mixture obtained in step (a) onto a release liner; (c) drying the wet-cast or coated homogeneous mixture provided in step (b); and (d) lamaminating the dried homogeneous mixture obtained in step (c) to said flexible backing.

Claim 5

An adhesive-coated sheet material comprising: (a) a flexible backing; (b) a pressure-sensitive adhesive-coating comprising a homogeneous mixture of: (i) an acrylic polymer comprising, as a major constituent, a hydrophobic monomeric acrylic or methacrylic acid ester of an alkyl alcohol, the alkyl alcohol containing 4 to 10 carbon atoms; (ii) a skin penetration enhancing combination comprising (1) ethyl oleate present in an amount by weight of about 2 to 15 percent of the total weight of said adhesive coating; and (2) glyceryl monolaurate which is present in an amount by weight of about 0.2 to 5 percent of the total weight of said adhesive coating, the relative amounts of ethyl oleate and glyceryl monolaurate further being such that said glyceryl monolaurate accentuates the penetration enhancement effect of said ethyl oleate; and (iii) nitroglycerin in an amount by weight of about 10 to 45 percent of the total weight of said adhesive coating; said sheet material being suitable for substantially continuous transdermal delivery of nitroglycerin to a subject over a prolonged period in an amount which is therapeutically effective for prophylactically treating angina pectoris and/or controlling hypertension and/or treating congestive heart failure.

Claim 6

An adhesive-coated sheet material comprising: (a) a flexible backing; (b) a pressure-sensitive adhesive-coating comprising a homogeneous mixture of: (i) an acrylic polymer comprising, as a major constituent, a hydrophobic monomeric acrylic or methacrylic acid ester of an alkyl alcohol, the alkyl alcohol containing 4 to 10 carbon atoms; (ii) a skin penetration enhancing combination comprising (1) ethyl oleate present in an amount by weight of about 2 to 15 percent of the total weight of said adhesive coating; and (2) glyceryl monolaurate which is present in an amount by weight of about 0.2 to 5 percent of the total weight of said adhesive coating, the relative amounts of ethyl oleate and glyceryl monolaurate further being such that said glyceryl monolaurate accentuates the penetration enhancement effect of said ethyl oleate; and (iii) nitroglycerin in an amount by weight of about 10 to 45 percent of the total weight of said adhesive coating; said sheet material being suitable for substantially continuous transdermal delivery of nitroglycerin to a subject over a prolonged period in an amount which is therapeutically effective for prophylactically treating angina pectoris and/or controlling hypertension and/or treating congestive heart failure.

Claim 7

A method of treating angina and/or controlling hypertension and/or treating congestive heart failure wherein an adhesive-coated sheet material according to claim 4 is applied and adhered to the skin of a mammal.

Claim 8

An adhesive-coated sheet material comprising: (a) a flexible backing; and (b) a pressure-sensitive adhesive-coating comprising a homogeneous mixture of: (i) a pressure-sensitive acrylic adhesive copolymer comprising A and B monomers as follows: A is a hydrophobic monomeric acrylic or methacrylic acid ester of an alkyl alcohol, the alkyl alcohol containing 4 to 10 carbon atoms, said A monomer being present in an amount by weight of about 80 to 98 percent of the total weight of all monomers in said copolymer; and B is a reinforcing monomer selected from the group consisting of acrylic acid, methacrylic acid, an alkyl acrylate or methacrylate containing one to 3 carbon atoms in the alkyl group, acrylamide, methacrylamide, a lower alkyl-substituted acrylamide, diacetone acrylamide, N-vinyl-2-pyrrolidone, a vinyl ether, a substituted ethylene and a vinyl ester, the B monomer being present in an amount by weight of about 2 to 20 percent of the total weight of all monomers in said copolymer; and (ii) nitroglycerin in an amount by weight of about 25 to 45 percent of the total weight of said adhesive coating; said sheet material being suitable for substantially continuous transdermal delivery of nitroglycerin to an subject over a prolonged period in an amount which is therapeutically effective for prophylactically treating angina pectoris and/or controlling hypertension and/or treating congestive heart failure.

Claim 9

An adhesive-coated sheet material comprising: (a) a flexible backing; and (b) a pressure-sensitive adhesive-coating comprising a homogeneous mixture of: (i) a pressure-sensitive acrylic adhesive copolymer comprising A and B monomers as follows: A is a hydrophobic monomeric acrylic or methacrylic acid ester of an alkyl alcohol, the alkyl alcohol containing 4 to 10 carbon atoms, said A monomer being present in an amount by weight of about 80 to 98 percent of the total weight of all monomers in said copolymer; and B is a reinforcing monomer selected from the group consisting of acrylic acid, methacrylic acid, an alkyl acrylate or methacrylate containing one to 3 carbon atoms in the alkyl group, acrylamide, methacrylamide, a lower alkyl-substituted acrylamide, diacetone acrylamide, N-vinyl-2-pyrrolidone, a vinyl ether, a substituted ethylene and a vinyl ester, the B monomer being present in an amount by weight of about 2 to 20 percent of the total weight of all monomers in said copolymer; and (ii) nitroglycerin in an amount by weight of about 25 to 45 percent of the total weight of said adhesive coating; said sheet material being suitable for substantially continuous transdermal delivery of nitroglycerin to an subject over a prolonged period in an amount which is therapeutically effective for prophylactically treating angina pectoris and/or controlling hypertension and/or treating congestive heart failure.

Claim 10

An adhesive-coated sheet material according to claim 6, wherein said adhesive copolymer comprises about 2 to 10% by weight of acrylamide and about 90 to 98% by weight of alkyl acrylate wherein the alkyl group contains six to ten carbon atoms.

Claim 11

A method of treating angina and/or controlling hypertension and/or treating congestive heart failure wherein an adhesive-coated sheet material according to claim 6 is applied and adhered to the skin of a mammal.

Claim 12

A process for preparing the adhesive-coated sheet material of claim 6, comprising the steps of: (a) forming a homogeneous mixture comprising nitroglycerin and said acrylic polymer, said nitroglycerin being present in said mixture in an amount sufficient so that said pressure-sensitive adhesive coating of said adhesive-coated sheet material comprises nitroglycerin in an amount by weight of about 25 to 45 percent of the total weight of said pressure-sensitive adhesive coating; (b) wet-casting or coating the homogeneous mixture obtained in step (a) onto a release liner; (c) drying the wet-cast or coated homogeneous mixture provided in step (b); and (d) laminating the dried homogeneous mixture obtained in step (c) to said flexible backing.

Claim 13

A process according to claim 9, wherein said flexible backing is substantially impermeable to nitroglycerin.

Claim 14

An adhesive-coated sheet material comprising: (a) a flexible backing; and (b) a pressure-sensitive adhesive-coating comprising a homogeneous mixture of: (i) a pressure-sensitive acrylic adhesive copolymer comprising A and B monomers as follows: A is a hydrophobic monomeric acrylic or methacrylic acid ester of an alkyl alcohol, the alkyl alcohol containing 4 to 10 carbon atoms, said A monomer being present in an amount by weight of about 80 to 98 percent of the total weight of all monomers in said copolymer; and B is a reinforcing monomer selected from the group consisting of acrylic acid, methacrylic acid, an alkyl acrylate or methacrylate containing one to 3 carbon atoms in the alkyl group, acrylamide, methacrylamide, a lower alkyl-substituted acrylamide, diacetone acrylamide, N-vinyl-2-pyrrolidone, a vinyl ether, a substituted ethylene and a vinyl ester, said B monomer being present in an amount by weight of about 2 to 20 percent of the total weight of all monomers in said copolymer. (ii) a skin penetration enhancing combination comprising (1) ethyl oleate present in an amount by weight of about 2 to 15 percent of the total weight of said adhesive coating; and (2) glyceryl monolaurate which is present in an amount by weight of about 0.2 to 5 percent of the total weight of said adhesive coating, the relative amounts of ethyl oleate and glyceryl monolaurate further being such that said glyceryl monolaurate accentuates the penetration enhancement effect of said ethyl oleate; and (iii) nitroglycerin in an amount by weight of about about 10 to 45 percent of the total weight of said adhesive coating; said sheet material being suitable for substantially continuous transdermal delivery of nitroglycerin to a subject over a prolonged period in an amount which is therapeutically effective for prophylactically treating angina pectoris and/or controlling hypertension and/or treating congestive heart failure.

Claim 15

An adhesive-coated sheet material comprising: (a) a flexible backing; and (b) a pressure-sensitive adhesive-coating comprising a homogeneous mixture of: (i) a pressure-sensitive acrylic adhesive copolymer comprising A and B monomers as follows: A is a hydrophobic monomeric acrylic or methacrylic acid ester of an alkyl alcohol, the alkyl alcohol containing 4 to 10 carbon atoms, said A monomer being present in an amount by weight of about 80 to 98 percent of the total weight of all monomers in said copolymer; and B is a reinforcing monomer selected from the group consisting of acrylic acid, methacrylic acid, an alkyl acrylate or methacrylate containing one to 3 carbon atoms in the alkyl group, acrylamide, methacrylamide, a lower alkyl-substituted acrylamide, diacetone acrylamide, N-vinyl-2-pyrrolidone, a vinyl ether, a substituted ethylene and a vinyl ester, said B monomer being present in an amount by weight of about 2 to 20 percent of the total weight of all monomers in said copolymer. (ii) a skin penetration enhancing combination comprising (1) ethyl oleate present in an amount by weight of about 2 to 15 percent of the total weight of said adhesive coating; and (2) glyceryl monolaurate which is present in an amount by weight of about 0.2 to 5 percent of the total weight of said adhesive coating, the relative amounts of ethyl oleate and glyceryl monolaurate further being such that said glyceryl monolaurate accentuates the penetration enhancement effect of said ethyl oleate; and (iii) nitroglycerin in an amount by weight of about about 10 to 45 percent of the total weight of said adhesive coating; said sheet material being suitable for substantially continuous transdermal delivery of nitroglycerin to a subject over a prolonged period in an amount which is therapeutically effective for prophylactically treating angina pectoris and/or controlling hypertension and/or treating congestive heart failure.

Claim 16

An adhesive-coated sheet material according to claim 11, wherein said glyceryl monolaurate is present in an amount by weight of about 0.5 to 2 percent.

Claim 17

A method of treating angina and/or controlling hypertension and/or treating congestive heart failure wherein an adhesive-coated sheet material according to claim 11 is applied and adhered to the skin of a mammal.

Claim 18

An adhesive composition comprising, as a homogeneous mixture, (i) a pressure-sensitive acrylic adhesive copolymer comprising A and B monomers as follows: A is a hydrophobic monomeric acrylic or methacrylic acid ester of an alkyl alcohol, the alkyl alcohol containing 4 to 10 carbon atoms, said A monomer being present in an amount by weight of about 80 to 98 percent of the total weight of all monomers in said copolymer; and B is a reinforcing monomer selected from the group consisting of acrylic acid, methacrylic acid, an alkyl acrylate or methacrylate containing one to 3 carbon atoms in the alkyl group, acrylamide, methacrylamide, a lower alkyl-substituted acrylamide, diacetone acrylamide, N-vinyl-2-pyrrolidone, a vinyl ether, a substituted ethylene and a vinyl ester, said B monomer being present in an amount by weight of about 2 to 20 percent of the total weight of all monomers in said copolymer; and (ii) nitroglycerin in an amount by weight of about 25 to 45 percent of the total weight of said adhesive copolymer and nitroglycerin; said adhesive composition being suitable for substantially continuous transdermal delivery of nitroglycerin to a subject over a prolonged period in an amount which is therapeutically effective for prophylactically treating angina pectoris and/or controlling hypertension and/or treating congestive heart failure.

Claim 19

An adhesive composition comprising, as a homogeneous mixture, (i) a pressure-sensitive acrylic adhesive copolymer comprising A and B monomers as follows: A is a hydrophobic monomeric acrylic or methacrylic acid ester of an alkyl alcohol, the alkyl alcohol containing 4 to 10 carbon atoms, said A monomer being present in an amount by weight of about 80 to 98 percent of the total weight of all monomers in said copolymer; and B is a reinforcing monomer selected from the group consisting of acrylic acid, methacrylic acid, an alkyl acrylate or methacrylate containing one to 3 carbon atoms in the alkyl group, acrylamide, methacrylamide, a lower alkyl-substituted acrylamide, diacetone acrylamide, N-vinyl-2-pyrrolidone, a vinyl ether, a substituted ethylene and a vinyl ester, said B monomer being present in an amount by weight of about 2 to 20 percent of the total weight of all monomers in said copolymer; and (ii) nitroglycerin in an amount by weight of about 25 to 45 percent of the total weight of said adhesive copolymer and nitroglycerin; said adhesive composition being suitable for substantially continuous transdermal delivery of nitroglycerin to a subject over a prolonged period in an amount which is therapeutically effective for prophylactically treating angina pectoris and/or controlling hypertension and/or treating congestive heart failure.

Claim 20

An adhesive composition comprising, as a homogeneous mixture, (i) a pressure-sensitive acrylic adhesive copolymer comprising A and B monomers as follows: A is a hydrophobic monomeric acrylic acid or methacrylic acid ester of an alkyl alcohl, the alkyl alcohol containing 4 to 10 carbon atoms, said A monomer being present in an amount by weight of about 80 to 98 percent of the total weight of all monomers in said copolymer; and B is a reinforcing monomer selected from the group consisting of acrylic acid, methacrylic acid, an alkyl acrylate or methacrylate containing one to 3 carbon atoms in the alkyl group, acrylamide, methacrylamide, a lower alkyl-substituted acrylamide, diacetone acrylamide, N-vinyl-2-pyrrolidone, a vinyl ether, a substituted ethylene and a vinyl ester, said B monomer being present in an amount by weight of about 2 to 20 percent of the total weight of all monomers in said copolymer; (ii) a skin penetration enhancing combination comprising (1) ethyl oleate; and (2) glyceryl monolaurate; and (iii) nitroglycerin; said ethyl oleate, said glyceryl monolaurate and nitroglycerin being present in an amount by weight of about 2 to 15 percent, about 0.2 to 5 percent, and about 10 to 45 percent, respectively, based upon the total weight of said acrylic copolymer, said fatty acid ester, glyceryl monolaurate and nitroglycerin, the relative amounts of ethyl oleate and glyceryl monolaurate further being such that said glyceryl monolaurate accentuates the penetration enhancement effect of said ethyl oleate; said adhesive composition being suitable for substantially continuous transdermal delivery of nitroglycerin to a subject over a prolonged period in an amount which is therapeutically effective for prophylactically treating angina and/or controlling hypertension and/or treating congestive heart failure.

Claim 21

An adhesive composition comprising, as a homogeneous mixture, (i) a pressure-sensitive acrylic adhesive copolymer comprising A and B monomers as follows: A is a hydrophobic monomeric acrylic acid or methacrylic acid ester of an alkyl alcohl, the alkyl alcohol containing 4 to 10 carbon atoms, said A monomer being present in an amount by weight of about 80 to 98 percent of the total weight of all monomers in said copolymer; and B is a reinforcing monomer selected from the group consisting of acrylic acid, methacrylic acid, an alkyl acrylate or methacrylate containing one to 3 carbon atoms in the alkyl group, acrylamide, methacrylamide, a lower alkyl-substituted acrylamide, diacetone acrylamide, N-vinyl-2-pyrrolidone, a vinyl ether, a substituted ethylene and a vinyl ester, said B monomer being present in an amount by weight of about 2 to 20 percent of the total weight of all monomers in said copolymer; (ii) a skin penetration enhancing combination comprising (1) ethyl oleate; and (2) glyceryl monolaurate; and (iii) nitroglycerin; said ethyl oleate, said glyceryl monolaurate and nitroglycerin being present in an amount by weight of about 2 to 15 percent, about 0.2 to 5 percent, and about 10 to 45 percent, respectively, based upon the total weight of said acrylic copolymer, said fatty acid ester, glyceryl monolaurate and nitroglycerin, the relative amounts of ethyl oleate and glyceryl monolaurate further being such that said glyceryl monolaurate accentuates the penetration enhancement effect of said ethyl oleate; said adhesive composition being suitable for substantially continuous transdermal delivery of nitroglycerin to a subject over a prolonged period in an amount which is therapeutically effective for prophylactically treating angina and/or controlling hypertension and/or treating congestive heart failure.

Claim 22

An adhesive-coated sheet material comprising: (a) a flexible-backing; and (b) a pressure-sensitive adhesive-coating contiguously adhered to one surface of said flexible backing and comprising a homogeneous mixture comprising: (i) an acrylic polymer comprising, as a major constituent, a hydrophobic monomeric acrylic or methacrylic acid ester of an alkyl alcohol, the alkyl alcohol containing 4 to 10 carbon atoms; and (iii) nitroglycerin in an amount of weight of about 25 to 45 percent of the total weight of said adhesive coating; said flexible backing being substantially impermeable to nitroglycerin contained in said adhesive coating and exhibiting substantially no uptake of nitroglycerin from said adhesive-coating and said sheet material being suitable for substantially continuous transdermal delivery of nitroglycerin to a subject over a prolonged period in an amount which is therapeutically effective for prophylactically treating angina pectoris and/or controlling hypertension and/or treating congestive hear failure.

Claim 23

An adhesive-coated sheet material comprising: (a) a flexible-backing; and (b) a pressure-sensitive adhesive-coating contiguously adhered to one surface of said flexible backing and comprising a homogeneous mixture comprising: (i) an acrylic polymer comprising, as a major constituent, a hydrophobic monomeric acrylic or methacrylic acid ester of an alkyl alcohol, the alkyl alcohol containing 4 to 10 carbon atoms; and (iii) nitroglycerin in an amount of weight of about 25 to 45 percent of the total weight of said adhesive coating; said flexible backing being substantially impermeable to nitroglycerin contained in said adhesive coating and exhibiting substantially no uptake of nitroglycerin from said adhesive-coating and said sheet material being suitable for substantially continuous transdermal delivery of nitroglycerin to a subject over a prolonged period in an amount which is therapeutically effective for prophylactically treating angina pectoris and/or controlling hypertension and/or treating congestive hear failure.

Claim 24

An adhesive-coated sheet material according to claim 16, wherein said pressure-sensitive adhesive-coating further comprises a fatty acid ester prepared from (i) a fatty acid containing about 14 to 20 carbon atoms and (ii) an alkyl alcohol containing 2 to about 6 carbon atoms and a single hydroxy, said fatty acid ester being present in an amount by weight of about 2 to 30% of the total weight of said adhesive coating and resulting in an enhanced penetration of nitroglycerin as compared to when no fatty acid ester is present.

Claim 25

An adhesive-coated sheet material according to claim 17, wherein said fatty acid ester is ethyl oleate which is present in an amount by weight of about 2 to 15% of the total weight of said adhesive coating, and wherein said pressure-sensitive adhesive-coating further comprises glyceryl monolaurate in an amount by weight of about 0.2 to 5% of the total weight of said adhesive coating, the relative amounts of said ethyl oleate and said glyceryl monolaurate further being such that said glyceryl monolaurate accentuates the penetration enhancement effect of said fatty acid ester.

Claim 26

An adhesive-coated sheet material according to claim 16, wherein nitroglycerin is present in an amount by weight of about 25 to 35% of the total weight of said adhesive coating.

Claim 27

An adhesive-coated sheet material according to claim 16, wherein said sheet material contains nitroglycerin in said adhesive coating in an amount providing about 5 to 25 mg nitroglycerin per 5 cm 2 of said sheet material.

Claim 28

An adhesive-coated sheet material according to claim 16, wherein said backing is occlusive.

Claim 29

An adhesive-coated sheet material comprising: (a) a flexible backing; and (b) a pressure-sensitive adhesive-coating contiguously adhered to one surface of said flexible backing and comprising a homogeneous mixture comprising: (i) a pressure-sensitive acrylic adhesive copolymer comprising A and B monomers as follows: A is a hydrophobic monomeric acrylic or methacrylic acid ester of an alkyl alcohol, the alkyl alcohol containing 4 to 10 carbon atoms, said A monomer being present in an amount by weight of about 80 to 98 percent of the total weight of all monomers in said copolymer; and B is a reinforcing monomer selected from the group consisting of acrylic acid, methacrylic acid, an alkyl acrylate or methacrylate containing one to 3 carbon atoms in the alkyl group, acrylamide, methacrylamide, a lower alkyl-substituted acrylamide, diacetone acrylamide, N-vinyl-2-pyrrolidone, a vinyl ether, a substituted ethylene and a vinyl ester, the B monomer being present in an amount by weight of about 2 to 20 to percent of the total weight of all monomers in said copolymer; and (ii) nitroglycerin in an amount by weight of about 25 to 45 percent of the total weight of said adhesive coating; said flexible backing being substantially impermeable to nitroglycerin contained in said adhesive coating and exhibiting substantially no uptake of nitroglycerin from said adhesive coating, and said sheet material being suitable for substantially continuous transdermal delivery of nitroglycerin to a subject over a prolonged period in an amount which is therapeutically effective for prophylactically treating angina pectoris and/or controlling heart failure.

Claim 30

An adhesive-coated sheet material comprising: (a) a flexible backing; and (b) a pressure-sensitive adhesive-coating contiguously adhered to one surface of said flexible backing and comprising a homogeneous mixture comprising: (i) a pressure-sensitive acrylic adhesive copolymer comprising A and B monomers as follows: A is a hydrophobic monomeric acrylic or methacrylic acid ester of an alkyl alcohol, the alkyl alcohol containing 4 to 10 carbon atoms, said A monomer being present in an amount by weight of about 80 to 98 percent of the total weight of all monomers in said copolymer; and B is a reinforcing monomer selected from the group consisting of acrylic acid, methacrylic acid, an alkyl acrylate or methacrylate containing one to 3 carbon atoms in the alkyl group, acrylamide, methacrylamide, a lower alkyl-substituted acrylamide, diacetone acrylamide, N-vinyl-2-pyrrolidone, a vinyl ether, a substituted ethylene and a vinyl ester, the B monomer being present in an amount by weight of about 2 to 20 to percent of the total weight of all monomers in said copolymer; and (ii) nitroglycerin in an amount by weight of about 25 to 45 percent of the total weight of said adhesive coating; said flexible backing being substantially impermeable to nitroglycerin contained in said adhesive coating and exhibiting substantially no uptake of nitroglycerin from said adhesive coating, and said sheet material being suitable for substantially continuous transdermal delivery of nitroglycerin to a subject over a prolonged period in an amount which is therapeutically effective for prophylactically treating angina pectoris and/or controlling heart failure.

Claim 31

An adhesive-coated sheet material according to claim 22, wherein said pressure-sensitive adhesive-coating further comprises a fatty acid ester prepared from (i) a fatty acid containing about 14 to 20 carbon atoms and (ii) an alkyl alcohl containing 2 to about 6 carbon atoms and a single hydroxy, said fatty acid ester being present in an amount by weight of about 2 to 30% of the total weight of said adhesive coating and resulting in an enhanced penetration of nitroglycerin as compared to when no fatty acid ester is present.

Claim 32

An adhesive-coated sheet material according to claim 23, wherein said fatty acid ester is ethyl oleate which is present in an amount by weight of about 2 to 15% of the total weight of said adhesive coating, and wherein said pressure-sensitive adhesive-coating further comprises glyceryl monolaurate in an amount of weight of about 0.2 to 5% of the total weight of said adhesive coating, the relative amounts of said ethyl oleate and said glyceryl monolaurate further being such that said glyceryl monolaurate accentuates the penetration enhancement effect of said fatty acid ester.

Claim 33

An adhesive-coated sheet material according to claim 22, wherein nitroglycerin is present in an amount by weight of about 25 to 35% of the total weight of said adhesive coating.

Claim 34

An adhesive-coated sheet material according to claim 22, wherein said sheet material contains nitroglycerin in said adhesive coating in an amount providing about 5 to 25 mg nitroglycerin per 5 cm 2 of said sheet material.

Claim 35

An adhesive-coated sheet material according to claim 22, wherein said backing is occlusive.

Claim 36

An adhesive-coated sheet material according to claim 22, wherein said alkyl alcohol of said A monomer contains 6 to 10 carbon atoms.

Claim 37

An adhesive-coated sheet material according to claim 28, wherein said A monomer is present in an amount by weight of about 88 to 96 percent of the total weight of all monomers in said copolymer.

Claim 38

A process according to claim 28, wherein said flexible backing is substantially impermeable to nitroglycerin.