US4968718A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Topically effective, nonsteroidal drug for use in external and internal eye inflammations
Assignee: University of Iowa Research Foundation
•
Filing: 1988-01-25
•
Granted: 1990-11-06
•
Expires: 2008-01-25
Abstract
Abstract A nonsteroidal anti-inflammatory drug which is phenylacetic acid derivative and methods of using the same in topically controlling eye inflammations.
Inventors
- 👤 Ronald D. Schoenwald
- 👤 Charles F. Barfknecht
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 15:54
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/21; A61K31/215; A61K31/22
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
89 words
A method of effectively and topically treating inflammations of the eye with nonsteroidal drugs so as to reduce unwanted systemic side effects, said method comprising: administering to an affected eye an inflammation reducing effective amount of a compound of the formula: ##STR3## wherein R equals hydrogen or C 1 to C 5 , X equals mono-, di-, tri- and hydroxy substituted C 2 to C 10 alkyls, and Y equals hydrogen or C 1 to C 5 straight or branched chain alkyl, or an ophthalmically effective salt form thereof.
Claim 2
Independent Claim
89 words
A method of effectively and topically treating inflammations of the eye with nonsteroidal drugs so as to reduce unwanted systemic side effects, said method comprising: administering to an affected eye an inflammation reducing effective amount of a compound of the formula: ##STR3## wherein R equals hydrogen or C 1 to C 5 , X equals mono-, di-, tri- and hydroxy substituted C 2 to C 10 alkyls, and Y equals hydrogen or C 1 to C 5 straight or branched chain alkyl, or an ophthalmically effective salt form thereof.
Claim 3
Dependent Claim
9 words
The method of claim 1 wherein X equals monohydroxyethoxy.
Claim 4
Dependent Claim
9 words
The method of claim 1 wherein X equals 2,3-dihydroxypropoxy.
Claim 5
Dependent Claim
9 words
The method of claim 2 wherein R equals hydrogen.
Claim 6
Dependent Claim
9 words
The method of claim 2 wherein R equals methyl.
Claim 7
Dependent Claim
22 words
The method of claim 2 wherein the amount of said compound is from about 0.05% by weight to about 5.0% by weight.
Claim 8
Dependent Claim
22 words
The method of claim 2 wherein the amount of said compound is from about 0.5% by weight to about 3.0% by weight.
Claim 9
Dependent Claim
71 words
A nonsteroidal pharmaceutical composition for topically treating inflammation of the eye comprising an inflammation reducing effective amount of a compound of the formula: ##STR4## wherein R equals hydrogen or C 1 to C 5 , X equals mono-, di-, tri- and tetrahydroxy substituted C 2 to C 10 alkyls, and Y equals hydrogen or C 1 to C 5 straight or branched chain alkyl, or an ophthalmically effective salt form thereof.
Claim 10
Dependent Claim
71 words
A nonsteroidal pharmaceutical composition for topically treating inflammation of the eye comprising an inflammation reducing effective amount of a compound of the formula: ##STR4## wherein R equals hydrogen or C 1 to C 5 , X equals mono-, di-, tri- and tetrahydroxy substituted C 2 to C 10 alkyls, and Y equals hydrogen or C 1 to C 5 straight or branched chain alkyl, or an ophthalmically effective salt form thereof.
Claim 11
Dependent Claim
9 words
The composition of claim 8 wherein X equals monohydroxyethoxy.
Claim 12
Dependent Claim
9 words
The composition of claim 8 wherein X equals 2,3-dihydroxypropoxy.
Claim 13
Dependent Claim
22 words
The composition of claim 8 wherein the amount of said compound is from about 0.05% by weight to about 5.0% by weight.
Claim 14
Dependent Claim
22 words
The composition of claim 11 wherein the amount of said compound is from about 0.5% by weight to about 3.0% by weight.
Claim 15
Dependent Claim
13 words
The composition of claim 9 wherein said composition is an eye drop solution.
Claim 16
Dependent Claim
11 words
The composition of claim 9 wherein said composition is an ointment.
Claim 17
Dependent Claim
12 words
The composition of claim 9 wherein said composition is an ophthalmic gel.
Claim 18
Dependent Claim
12 words
The composition of claim 9 wherein "R" of said compound is hydrogen.
Claim 19
Dependent Claim
12 words
The composition of claim 9 wherein "R" of said compound is methyl.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-11-05 | 1994-05-07 | 1994-11-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-11-05 | 1998-05-07 | 1998-11-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-11-05 | 2002-05-07 | 2002-11-06 | $7700.00 | Window Closed / Lapsed |