US4028404A
Expired / Lapsed
US
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Acetic acid derivatives
Assignee: Allen and Hanburys Ltd
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Filing: 1974-04-26
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Granted: 1977-06-07
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Expires: 1994-04-26
Abstract
Abstract Novel phenylacetic derivatives are provided of the general formula ##STR1## in which R 1 , R 2 , R 3 and R 4 are as defined herein, and pharmaceutically acceptable salts thereof. These have anti-inflammatory or analgetic activity. The invention also provides a process for the production of these compounds from a ketone of the structure: ##STR2## It also provides pharmaceutical compositions including phenylacetic derivatives.
Inventors
- 👤 David Edmund Bays
- 👤 Roy Vivian Foster
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 19:47
CPC Classifications
C; C07; C07C; C07C45/00; C07C45/45; C07C45/46; C07C255/00; C07C45/004; C07C45/61; C07C45/63; C07C59/00; C07C59/40; C07C59/76; C07C59/84; C07C59/86
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
109 words
A phenylacetic acid derivative of the general formula: ##STR12## in which the group R 3 CO-- may only be meta or para oriented with respect to the side chain --CR 1 R 2 --COR 4 and in which R 1 and R 2 , which may be the same or different, are each hydrogen or alkyl containing from 1 to 6 carbon atoms, R 3 is cycloalkyl containing from 3 to 9 carbon atoms, and R 4 is hydroxy or lower alkoxy containing from 1 to 6 carbon atoms, or a pharmaceutically acceptable salt of said derivative in which R 4 is hydroxy with an organic or inorganic base.
Claim 2
Dependent Claim
109 words
A phenylacetic acid derivative of the general formula: ##STR12## in which the group R 3 CO-- may only be meta or para oriented with respect to the side chain --CR 1 R 2 --COR 4 and in which R 1 and R 2 , which may be the same or different, are each hydrogen or alkyl containing from 1 to 6 carbon atoms, R 3 is cycloalkyl containing from 3 to 9 carbon atoms, and R 4 is hydroxy or lower alkoxy containing from 1 to 6 carbon atoms, or a pharmaceutically acceptable salt of said derivative in which R 4 is hydroxy with an organic or inorganic base.
Claim 3
Dependent Claim
10 words
The compound of claim 1, which is (4-cyclohexanoylphenyl) acetic acid.
Claim 4
Dependent Claim
10 words
The compound of claim 1, wherein R 3 is cyclobutyl.
Claim 5
Dependent Claim
10 words
The compound of claim 1, wherein R 3 is cyclopentyl.
Claim 6
Dependent Claim
10 words
The compound of claim 1, wherein R 3 is cyclohexyl.
Claim 7
Dependent Claim
9 words
The compound of claim 1, which is p-(cyclobutylcarbonyl)phenylacetic acid.
Claim 8
Dependent Claim
9 words
The compound of claim 1, which is p-(cyclohexylcarbonylhydratropic acid.
Claim 9
Dependent Claim
29 words
An anti-inflammatory and analgetic composition containing an anti-inflammatory effective amount or an analgetic effective amount of the compound of claim 1 and a pharmaceutically acceptable carrier or diluent therefor.
Claim 10
Dependent Claim
13 words
The composition according to claim 8, in which the compound is (4-cyclohexylcarbonylphenyl)acetic acid.
Claim 11
Dependent Claim
10 words
The composition of claim 8, wherein R 3 is cyclobutyl.
Claim 12
Dependent Claim
10 words
The composition of claim 8, wherein R 3 is cyclopentyl.
Claim 13
Dependent Claim
10 words
The composition of claim 8, wherein R 3 is cyclohexyl.
Claim 14
Dependent Claim
13 words
The composition according to claim 8, in which the compound is p-(cyclobutylcarbonyl)phenylacetic acid.
Claim 15
Dependent Claim
13 words
The composition according to claim 8, in which the compound is p-(cyclohexylcarbonyl)hydratropic acid.
References Cited (Backward Citations)
GB1226344A
Cited
US3839431A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-06-06 | 1980-12-06 | 1981-06-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-06-06 | 1984-12-06 | 1985-06-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-06-06 | 1988-12-06 | 1989-06-07 | $7700.00 | Window Closed / Lapsed |