US4599360A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Ophthalmic anti-inflammatory agents
Assignee: Sankyo Co Ltd
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Filing: 1984-08-09
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Granted: 1986-07-08
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Expires: 2004-08-09
Abstract
Abstract Compounds of formula: <IMAGE> (wherein R represents hydrogen or methyl, >A-B- represents a >CH-CH2- or >C=CH- group; >C-Z represents a >C=O or >CH-OH group; and n represents 1 or 2) and ophthalmically acceptable salts and esters thereof are useful as ophthalmic anti-inflammatory agents.
Inventors
- 👤 Masaharu Fukami
- 👤 Atsusuke Terada
- 👤 Kazue Hasegawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 17:40
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K31/215; A61K31/185; A61K31/19; A61P; A61P27/00; A61P27/02
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
75 words
A method for the treatment or prophylaxis of ocular inflammation comprising applying to the surface of the mammalian eye an anti-inflammatory effective amount of a phenylacetic acid derivative of the formula: ##STR5## wherein: R represents the hydrogen atom or the methyl group; >A--B-- represents a >CH--CH 2 -- or >C═CH-- group; >C--Z represents a >C═O (carbonyl) group or a >CH--OH group; and n is 1 or 2; or an ophthalmically acceptable salt or ester thereof.
Claim 2
Independent Claim
75 words
A method for the treatment or prophylaxis of ocular inflammation comprising applying to the surface of the mammalian eye an anti-inflammatory effective amount of a phenylacetic acid derivative of the formula: ##STR5## wherein: R represents the hydrogen atom or the methyl group; >A--B-- represents a >CH--CH 2 -- or >C═CH-- group; >C--Z represents a >C═O (carbonyl) group or a >CH--OH group; and n is 1 or 2; or an ophthalmically acceptable salt or ester thereof.
Claim 3
Dependent Claim
9 words
The method of claim 1, wherein R is methyl.
Claim 4
Dependent Claim
45 words
The method of claim 1, wherein said agent is selected from the group consisting of: 2-[4-(2-oxocyclopentylmethyl)phenyl]propionic acid; 2-[4-(2-oxocyclopentylmethyl)phenyl]acetic acid; 2-[4-(2-oxocyclohexylmethyl)phenyl]propionic acid; 2-[4-(2-oxocyclopentylidenemethyl)phenyl]propionic acid; 2-[4-(2-oxocyclohexylidenemethyl)phenyl]propionic acid; 2-[4-(2-hydroxycyclopentylidenemethyl)phenyl]propionic acid; 2-[4-(2-hydroxycyclohexylidenemethyl)phenyl]propionic acid; 2-[4-(trans-2-hydroxycyclopentylmethyl)phenyl]propionic acid; 2-[4-(trans-2-hydroxycyclohexylmethyl)phenyl]propionic acid; 2-[4-(cis-2-hydroxycyclopentylmethyl)phenyl]propionic acid; and 2-[4-(cis-2-hydroxycyclohexylmethyl)phenyl]propionic acid and ophthalmically acceptable salts and esters thereof.
Claim 5
Dependent Claim
13 words
The method of claim 1, wherein said mammalian eye is a human eye.
Claim 6
Dependent Claim
14 words
The method of claim 1, wherein an eyedrop formulation is instilled into the eye.
Claim 7
Dependent Claim
17 words
The method of claim 1, wherein an eye lotion is applied to the surface of said eye.
Claim 8
Dependent Claim
17 words
The method of claim 1, wherein an eye ointment is applied to the surface of said eye.
Claim 9
Independent Claim
43 words
A method for the treatment or prophylaxis of ocular inflammation comprising applying to the surface of the mammalian eye an anti-inflammatory effective amount of a phenylacetic acid derivative selected from the group consisting of: sodium 2-[4-(2-oxocyclopentylmethyl)phenyl]propionate; sodium 2-[4-(2-oxocyclohexylidenemethyl)phenyl]propionate; sodium 2-[4-(trans-2-hydroxycyclopentylmethyl)phenyl]propionate; and 2-[4-(2-oxocyclohexylidenemethyl)phenyl]propionic acid.
Claim 10
Independent Claim
43 words
A method for the treatment or prophylaxis of ocular inflammation comprising applying to the surface of the mammalian eye an anti-inflammatory effective amount of a phenylacetic acid derivative selected from the group consisting of: sodium 2-[4-(2-oxocyclopentylmethyl)phenyl]propionate; sodium 2-[4-(2-oxocyclohexylidenemethyl)phenyl]propionate; sodium 2-[4-(trans-2-hydroxycyclopentylmethyl)phenyl]propionate; and 2-[4-(2-oxocyclohexylidenemethyl)phenyl]propionic acid.
Claim 11
Dependent Claim
13 words
The method of claim 8, wherein said mammalian eye is a human eye.
Claim 12
Dependent Claim
14 words
The method of claim 9, wherein an eyedrop formulation is instilled into the eye.
Claim 13
Dependent Claim
17 words
The method of claim 9, wherein an eye lotion is applied to the surface of said eye.
Claim 14
Dependent Claim
17 words
The method of claim 9, wherein an eye ointment is applied to the surface of said eye.
Claim 15
Dependent Claim
14 words
The method of claim 3, wherein an eyedrop formulation is instilled into the eye.
Claim 16
Dependent Claim
17 words
The method of claim 3, wherein an eye lotion is applied to the surface of said eye.
Claim 17
Dependent Claim
17 words
The method of claim 3, wherein an eye ointment is applied to the surface of said eye.
Claim 18
Dependent Claim
12 words
The method of claim 9, wherein said phenylacetic derivative is sodium 2-[4-(2-oxocyclopentylmethyl)phenyl]propionate.
Claim 19
Dependent Claim
12 words
The method of claim 9, wherein said phenylacetic derivative is sodium 2-[4-(2-oxocyclohexylidenemethyl)phenyl]propionate.
Claim 20
Dependent Claim
12 words
The method of claim 9, wherein said phenylacetic derivative is sodium 2-[4-(trans-2-hydroxycyclopentylmethyl)phenyl]propionate.
Claim 21
Dependent Claim
12 words
The method of claim 9, wherein said phenylacetic derivative is 2-[4-(2-oxocyclohexylidenemethyl)phenyl]propionic acid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-07-07 | 1990-01-06 | 1990-07-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-07-07 | 1994-01-06 | 1994-07-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-07-07 | 1998-01-06 | 1998-07-08 | $7700.00 | Window Closed / Lapsed |