US4400534A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Analgesic and anti-inflammatory agents
Assignee: Sankyo Co Ltd
•
Filing: 1981-12-17
•
Granted: 1983-08-23
•
Expires: 2001-12-17
Abstract
Abstract Compounds of formula (I): ##STR1## its salts, and resolved forms thereof, especially the compound of formula (II): ##STR2## and its salts are new analgesic and/or anti-inflammatory agents. The agents are prepared by resolution at the 2-position of a suitable starting material such as the compound (IV): ##STR3## or an optionally partly resolved form thereof, with subsequent reduction and optional resolution to give the trans form.
Inventors
- 👤 Atsusuke Terada
- 👤 Eiichi Misaka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 02:11
CPC Classifications
C; C07; C07C; C07C59/00; C07C59/40; C07C59/42; C07C59/54; A; A61; A61P; A61P25/00; A61P25/04; A61P29/00; A61P43/00; C07C51/00; C07C51/42; C07C51/487
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
13 words
(2S)-2-[4-(2-hydroxycyclopentan-1-ylmethyl)phenyl]propionic acid of the formula (I): ##STR8## or a pharmaceutically active salt thereof.
Claim 2
Dependent Claim
13 words
(2S)-2-[4-(2-hydroxycyclopentan-1-ylmethyl)phenyl]propionic acid of the formula (I): ##STR8## or a pharmaceutically active salt thereof.
Claim 3
Dependent Claim
18 words
The acid of claim 1 or a salt thereof, wherein the 1" and 2"-substituents are in trans relationship.
Claim 4
Dependent Claim
13 words
(2S)-2-{4-[(2S,1R)-2-hydroxycyclopentan-1-ylmethyl[phenyl}propionic acid of the formula (II): ##STR9## or a pharmaceutically active salt thereof.
Claim 5
Dependent Claim
13 words
(2S)-2-{4-[(2S,1R)-2-hydroxycyclopentan-1-ylmethyl[phenyl}propionic acid of the formula (II): ##STR9## or a pharmaceutically active salt thereof.
Claim 6
Dependent Claim
23 words
A pharmaceutical composition comprising an acid or salt according to any of claims 1, 2 and 3, together with a pharmaceutically acceptable vehicle.
Claim 7
Dependent Claim
20 words
A pharmaceutical composition formulated for oral, rectal or topical administration and comprising the acid or salt thereof of claim 3.
References Cited (Backward Citations)
US3649678A
Cited
US4137324A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-08-22 | 1987-02-21 | 1987-08-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-08-22 | 1991-02-21 | 1991-08-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-08-22 | 1995-02-21 | 1995-08-23 | $7700.00 | Window Closed / Lapsed |