Patent US4965253A successfully refreshed from Google Patents.
US4965253A
Expired / Lapsed
US
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Viscoelastic material for ophthalmic surgery
Assignee: University of Florida Research Foundation Inc
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Filing: 1987-10-14
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Granted: 1990-10-23
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Expires: 2007-10-14
Abstract
Abstract An ophthalmic surgical procedure wherein the anterior or posterior chamber of the eye is filled with viscoelastic space-filling and ocular tissue protective surgical material, the improvement comprising the utilization therein of a composition particularly adapted for use as an ophthalmic viscoelastic surgical material in the anterior or posterior chamber of the eye consisting of an aqueous solution containing from about 1.5% to about 25%, by weight, of a physiologically acceptable, water-soluble polyvinylpyrrolidone polymer or polyvinylpyrrolidone copolymer, having a molecular weight greater than 500,000, said aqueous solution having a viscosity greater than about 5,000 centipoises, measured at 25 DEG C. using a Brookfield viscometer.
Inventors
- 👤 Eugene P. Goldberg
- 👤 Moshe Yalon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:34
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61L31/145; A61K; A61K31/00; A61K31/74; A61K31/785; A61K31/787; A61K31/79; A61K9/00; A61K9/0012; A61K9/0048; A61L31/04; A61L31/041; A61L31/048; A61L2430/00; A61L2430/16
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
72 words
A composition particularly adapted for use as an ophthalmic viscoelastic surgical material in the anterior or posterior chamber of the eye consisting of an aqueous solution containing at least about 1.5% to about 25%, by weight, of a physiologically acceptable, water-soluble polyvinylpyrrolidone polymer or polyvinylpyrrolidone copolymer, having a molecular weight greater than 500,000, said aqueous solution having a viscosity greater than about 5,000 centipoises, measured at 25° C. using a Brookfield viscometer.
Claim 2
Dependent Claim
72 words
A composition particularly adapted for use as an ophthalmic viscoelastic surgical material in the anterior or posterior chamber of the eye consisting of an aqueous solution containing at least about 1.5% to about 25%, by weight, of a physiologically acceptable, water-soluble polyvinylpyrrolidone polymer or polyvinylpyrrolidone copolymer, having a molecular weight greater than 500,000, said aqueous solution having a viscosity greater than about 5,000 centipoises, measured at 25° C. using a Brookfield viscometer.
Claim 3
Dependent Claim
17 words
The composition of claim 1 wherein said aqueous solution comprises a physiological saline solution of said polyvinylpyrrolidone.
Claim 4
Dependent Claim
18 words
The composition of claim 1 wherein said aqueous solution comprises a buffered physiological saline solution of said polyvinylpyrrolidone.
Claim 5
Dependent Claim
21 words
The composition of claim 1 wherein said copolymer comprises at least about 50 mol. % N-Vinylpyrrolidone and the comonomer is hydrophilic.
Claim 6
Dependent Claim
19 words
The composition of claim 1 wherein said copolymer comprises a copolymer of N-Vinylpyrrolidone and an anionic or cationic comonomer.
Claim 7
Dependent Claim
24 words
The composition of claim 1 wherein said solution of polyvinylpyrrolidone has a viscosity in the range of from about 5,000 to about 500,000 cps.
Claim 8
Dependent Claim
18 words
The composition of claim 1 additionally containing one or more different viscoelastic material miscible with said polyvinylpyrrolidone solution.
Claim 9
Dependent Claim
23 words
The composition of claim 7 wherein said different viscoelastic material is selected from the group consisting of hyaluronic acid, chondroitin sulfate and carboxymethylcellulose.
Claim 10
Dependent Claim
29 words
The composition of claim 1 or 7 wherein said compositions are useful as a vitreous replacement or injectable into the vitreous of the eye in an ophthalmic surgical procedure.
Claim 11
Dependent Claim
25 words
A composition according to claim 1 wherein said polyvinylpyrrolidone or polyvinylpyrrolidone copolymer is prepared by gamma-irradiation induced polymerization of N-vinylpyrrolidone in a substantially aqueous solution.
Claim 12
Dependent Claim
42 words
In an ophthalmic surgical procedure wherein the anterior or posterior chamber of the eye is filled with a viscoelastic space-filling and ocular tissue protective surgical material, the improvement comprising the utilization therein of the composition of claim 1 as said surgical material.
Claim 13
Dependent Claim
15 words
An ophthalmic surgical procedure according to claim 11 wherein said surgery comprises intraocular lens implantation.
Claim 14
Dependent Claim
14 words
An ophthalmic surgical procedure according to claim 11 wherein said surgery comprises cataract surgery.
Claim 15
Dependent Claim
15 words
An ophthalmic surgical procedure according to claim 11 wherein said surgery comprises a corneal transplant.
Claim 16
Dependent Claim
14 words
An ophthalmic surgical procedure according to claim 11 wherein said surgery comprises glaucoma surgery.
Claim 17
Dependent Claim
14 words
An ophthalmic surgical procedure according to claim 11 wherein said surgery comprises retinal surgery.
Claim 18
Dependent Claim
14 words
An ophthalmic surgical procedure according to claim 11 wherein said surgery comprises vitreous replacement.
Claim 19
Dependent Claim
26 words
An ophthalmic surgical procedure according to claim 11 wherein said ophthalmic surgical material additionally contains one or more different viscoelastic material miscible with said polyvinylpyrrolidone solution.
Claim 20
Dependent Claim
26 words
An ophthalmic surgical procedure according to claim 18 wherein said different viscoelastic material is selected from the group consisting of hyaluronic acid, chondroitin sulfate and carboxymethylcellulose.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1993-10-22 | 1994-04-23 | 1994-10-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-10-22 | 1998-04-23 | 1998-10-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-10-22 | 2002-04-23 | 2002-10-23 | $7700.00 | Window Closed / Lapsed |