US4486416A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Protection of human and animal cells subject to exposure to trauma
Assignee: Individual
•
Filing: 1981-03-02
•
Granted: 1984-12-04
•
Expires: 2001-03-02
Abstract
Abstract Damage to endothelial and epithelial cells subject to surgery can be substantially minimized by using chondroitin sulphate. This method is particularly useful when applied prior to ophthalmic surgery, particularly intraocular lens implantation surgery.
Inventors
- 👤 David B. Soll
- 👤 Sol E. Harrison
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:50
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61K31/737; A61K2300/00
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
40 words
A method of protecting human and animal corneal endothelial cells subject to exposure to trauma, which comprises administering a prophylactically effective amount of chondroitin sulfate to said cells such that chondroitin sulfate is present during said exposure to said trauma.
Claim 2
Independent Claim
40 words
A method of protecting human and animal corneal endothelial cells subject to exposure to trauma, which comprises administering a prophylactically effective amount of chondroitin sulfate to said cells such that chondroitin sulfate is present during said exposure to said trauma.
Claim 3
Dependent Claim
27 words
A method according to claim 1 wherein said chondroitin sulfate is selected from the group consisting of chondroitin sulfate A, chondroitin sulfate B and chondroitin sulfate C.
Claim 4
Dependent Claim
19 words
A method according to claim 1 wherein said chondroitin sulfate is injected into the anterior chamber of the eye.
Claim 5
Dependent Claim
11 words
A method according to claim 1 wherein said trauma is surgery.
Claim 6
Dependent Claim
14 words
A method according to claim 4 wherein said surgery is intraocular lens implantation surgery.
Claim 7
Dependent Claim
15 words
A method according to claim 1 wherein said chondroitin sulfate is administered in a solution.
Claim 8
Dependent Claim
17 words
A method according to claim 1 which includes administering chondroitin sulfate during said exposure to said trauma.
Claim 9
Dependent Claim
18 words
A method according to claim 1 which includes administering chondroitin sulfate prior to said exposure to said trauma.
Claim 10
Dependent Claim
18 words
A method according to claim 1 which further comprises administering chondroitin sulfate after said exposure to said trauma.
Claim 11
Independent Claim
55 words
A method of protecting corneal endothelial cells of a patient from the adverse effects otherwise caused by the implantation of an intraocular lens in the eye of a patient which comprises administering a prophylactically effecting amount of chondroitin sulphate such that said chondroitin sulphate is in contact with the cells and present during said implantation.
Claim 12
Independent Claim
55 words
A method of protecting corneal endothelial cells of a patient from the adverse effects otherwise caused by the implantation of an intraocular lens in the eye of a patient which comprises administering a prophylactically effecting amount of chondroitin sulphate such that said chondroitin sulphate is in contact with the cells and present during said implantation.
Claim 13
Dependent Claim
34 words
A method according to claim 10 wherein prior to said implantation of the intraocular lens, chondroitin sulphate is instilled into the anterior chamber of the eye to coat the cells and maintain the chamber.
Claim 14
Dependent Claim
27 words
A method according to claim 10 wherein said chondroitin sulphate is selected from the group consisting of chondroitin sulphate A, chondroitin sulphate B and chondroitin sulphate C.
References Cited (Backward Citations)
US28093A
Cited
US30239A
Cited
US1700691A
Cited
US1950100A
Cited
US2022890A
Cited
US2187766A
Cited
US2143475A
Cited
US2320479A
Cited
US2717227A
Cited
US3194732A
Cited
US3196075A
Cited
US3318774A
Cited
US3211616A
Cited
USRE28093E
Cited
US3172815A
Cited
US3329572A
Cited
US3476855A
Cited
US3478146A
Cited
US3462412A
Cited
US3558771A
Cited
US3903268A
Cited
US3632754A
Cited
US3624201A
Cited
US3672954A
Cited
US3655416A
Cited
US3911116A
Cited
US3895106A
Cited
US3895107A
Cited
US3772432A
Cited
US3914413A
Cited
US4094973A
Cited
US3966908A
Cited
US4141973A
Cited
US4141973B1
Cited
USRE30239E
Cited
US4240163A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-12-04 | 1988-06-04 | 1988-12-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-12-04 | 1992-06-04 | 1992-12-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-12-04 | 1996-06-04 | 1996-12-04 | $7700.00 | Window Closed / Lapsed |