US4136173A
Expired / Lapsed
US
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Mixed xanthan gum and locust beam gum therapeutic compositions
Assignee: Wyeth LLC
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Filing: 1977-01-31
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Granted: 1979-01-23
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Expires: 1997-01-31
Abstract
Abstract New compositions comprising xanthan gum, locust bean gum, and a pharmaceutical agent in a pharmaceutically acceptable liquid vehicle. More specifically these compositions are useful in drug delivery systems, particularly for ophthalmic drugs.
Inventors
- 👤 Matura K. Pramoda
- 👤 Song-Ling Lin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:40
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61K47/00; A61K47/30; A61K47/36; A61K9/00; A61K9/0012; A61K9/0048
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
108 words
A pharmaceutical composition consisting essentially of a pH sensitive solution of a pharmaceutically acceptable liquid vehicle of xanthan gum, locust bean gum and a therapeutically effective amount of a pharmaceutically active drug in said vehicle; wherein said mixed gums together comprise about 0.01-1.0% weight by volume of the liquid composition; and wherein the percent of xanthan gum in the mixed gums is from about 6-94% of the total gum content, the remainder being locust bean gum; said composition being a liquid at a pH of less than about 3.5-5 and a gel at a pH above about 5; and wherein said liquid vehicle comprises 60-100% water by volume.
Claim 2
Dependent Claim
108 words
A pharmaceutical composition consisting essentially of a pH sensitive solution of a pharmaceutically acceptable liquid vehicle of xanthan gum, locust bean gum and a therapeutically effective amount of a pharmaceutically active drug in said vehicle; wherein said mixed gums together comprise about 0.01-1.0% weight by volume of the liquid composition; and wherein the percent of xanthan gum in the mixed gums is from about 6-94% of the total gum content, the remainder being locust bean gum; said composition being a liquid at a pH of less than about 3.5-5 and a gel at a pH above about 5; and wherein said liquid vehicle comprises 60-100% water by volume.
Claim 3
Dependent Claim
15 words
The composition of claim 1 wherein said gums comprise about 0.15-0.5% of the liquid composition.
Claim 4
Dependent Claim
30 words
The composition of claim 1 wherein the percent of xanthan gum in the mixed gums is from about 40-60% of the total gum content, the remainder being locust bean gum.
Claim 5
Dependent Claim
13 words
The composition of claim 1 wherein said drug is an ophthalmically active drug.
Claim 6
Dependent Claim
11 words
The composition of claim 4 wherein said drug is echothiophate iodide.
Claim 7
Dependent Claim
11 words
The composition of claim 4 wherein said drug is pilocarpine hydrochloride.
Claim 8
Dependent Claim
25 words
The composition of claim 4 wherein said drug is at least one selected from the group consisting of phenylephrine hydrochloride, prednisolone acetate and sulfacetamide sodium.
Claim 9
Dependent Claim
11 words
The composition of claim 4 wherein said drug is epinephrine bitartarate.
Claim 10
Dependent Claim
15 words
The composition of claim 4 wherein said drug is the aldose reductase inhibitor 1,3-dioxo-lH-benz[de]isoquinoline-2(3H)-acetic acid.
Claim 11
Dependent Claim
10 words
The composition of claim 4 wherein said drug is carbachol.
Claim 12
Dependent Claim
10 words
The composition of claim 1 wherein said drug is gonadorelin.
Claim 13
Dependent Claim
22 words
The composition of claim 1 wherein said drug is at least one selected from the group consisting of neomycin sulfate and dexamethasone.
Claim 14
Dependent Claim
96 words
An ophthalmic composition for the administration of a drug to the eye consisting essentially of a pH sensitive solution in a pharmaceutically acceptable liquid vehicle of about 0.04% to about 0.4% xanthan gum, about 0.06% to about 0.4% locust bean gum, wherein said gums together comprise about 0.1% to about 0.5% of said composition; about 0.01% to about 0.25% of echothiophate iodide; wherein the pH of said composition is adjusted to a pH of less than about 3.5-5, said percentages being expressed as weight per volume and wherein said liquid vehicle comprises 60-100% water by volume.
Claim 15
Dependent Claim
96 words
An ophthalmic composition for the administration of a drug to the eye consisting essentially of a pH sensitive solution in a pharmaceutically acceptable liquid vehicle of about 0.04% to about 0.4% xanthan gum, about 0.06% to about 0.4% locust bean gum, wherein said gums together comprise about 0.1% to about 0.5% of said composition; about 0.01% to about 0.25% of echothiophate iodide; wherein the pH of said composition is adjusted to a pH of less than about 3.5-5, said percentages being expressed as weight per volume and wherein said liquid vehicle comprises 60-100% water by volume.
Claim 16
Dependent Claim
93 words
An ophthalmic composition for the administration of a drug to the eye in a pharmaceutically acceptable liquid vehicle consisting essentially of about 0.1% to about 0.4% of xanthan gum, about 0.1% to about 0.4% of locust bean gum, wherein said gums together comprise about 0.2% to about 0.5% of said composition; about 0.01% to about 0.05% of pilocarpine; and wherein the pH of said composition is adjusted to a pH of less than about 3.5-5, said percentages being expressed as weight per volume and wherein said liquid vehicle comprises 60-100% water by volume.
Claim 17
Dependent Claim
93 words
An ophthalmic composition for the administration of a drug to the eye in a pharmaceutically acceptable liquid vehicle consisting essentially of about 0.1% to about 0.4% of xanthan gum, about 0.1% to about 0.4% of locust bean gum, wherein said gums together comprise about 0.2% to about 0.5% of said composition; about 0.01% to about 0.05% of pilocarpine; and wherein the pH of said composition is adjusted to a pH of less than about 3.5-5, said percentages being expressed as weight per volume and wherein said liquid vehicle comprises 60-100% water by volume.
Claim 18
Dependent Claim
68 words
An opthalmic composition consisting essentially of a pH sensitive solution in a pharmaceutically acceptable liquid vehicle of about 0.5% of xanthan gum; about 0.5% of locust bean gum; and a therapeutically effective dosage of 1,3-dioxo-lH-benz[de]isoquinoline-2(3H)-acetic acid; wherein the pH of said liquid composition is greater than about 5; and wherein said percentage is expressed as weight per volume; and wherein said liquid vehicle comprises 60-100% water by volume.
Claim 19
Dependent Claim
68 words
An opthalmic composition consisting essentially of a pH sensitive solution in a pharmaceutically acceptable liquid vehicle of about 0.5% of xanthan gum; about 0.5% of locust bean gum; and a therapeutically effective dosage of 1,3-dioxo-lH-benz[de]isoquinoline-2(3H)-acetic acid; wherein the pH of said liquid composition is greater than about 5; and wherein said percentage is expressed as weight per volume; and wherein said liquid vehicle comprises 60-100% water by volume.
Claim 20
Independent Claim
43 words
A method for increasing the effectiveness in a mammalian patient of a therapeutically effetive amount of a drug in a topically administered liquid composition which consists essentially of incorporating within said composition an adjuvantally effective amount of xanthan gum and locust bean gum.
Claim 21
Independent Claim
43 words
A method for increasing the effectiveness in a mammalian patient of a therapeutically effetive amount of a drug in a topically administered liquid composition which consists essentially of incorporating within said composition an adjuvantally effective amount of xanthan gum and locust bean gum.
Claim 22
Dependent Claim
91 words
An ophthalmic composition for the administration of drug to the eye in a pharmaceutically acceptable liquid vehicle consisting essentially of about 0.1% to about 0.4% of xanthan gum, about 0.1% to about 0.4% of locust bean gum, wherein said gums together comprise about 0.2% to about 0.5% of said composition; and a therapeutically effective dosage of carbachol; wherein the pH of said composition is adjusted to a pH of less than about 3.5-5, said percentages being expressed as weight per volume; and wherein said liquid vehicle comprises 60-100% water by volume.
Claim 23
Dependent Claim
91 words
An ophthalmic composition for the administration of drug to the eye in a pharmaceutically acceptable liquid vehicle consisting essentially of about 0.1% to about 0.4% of xanthan gum, about 0.1% to about 0.4% of locust bean gum, wherein said gums together comprise about 0.2% to about 0.5% of said composition; and a therapeutically effective dosage of carbachol; wherein the pH of said composition is adjusted to a pH of less than about 3.5-5, said percentages being expressed as weight per volume; and wherein said liquid vehicle comprises 60-100% water by volume.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-01-22 | 1982-07-24 | 1983-01-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-01-22 | 1986-07-24 | 1987-01-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-01-22 | 1990-07-24 | 1991-01-23 | $7700.00 | Window Closed / Lapsed |