US3900569A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Direct compression vehicle
Assignee: Sucrest Corp
•
Filing: 1972-09-15
•
Granted: 1975-08-19
•
Expires: 1992-09-15
Abstract
Abstract An intimate, co-dried mixture of a major amount of tricalcium phosphate and a minor amount of locust bean gum is useful for the preparation of tablets by the direct compression technique. The mixture is blended with an active material and, if desired, fillers, disintegrating agents and lubricants, and the resulting blend is compressed without prior granulation or slugging to form a tablet containing at least about 10 weight per cent of the codried mixture.
Inventors
- 👤 Anthony Monti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:25
CPC Classifications
A; A61; A61J; A61J3/00; A61J3/10; A23; A23P; A23P10/00; A23P10/20; A23P10/28; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2009; A61K9/2022; A61K9/205
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
160 words
A PARTICULATE COMPOSITION USEFUL AS A DIRECT COMPRESSION VEHICLE FOR FORMING TABLETS CONSISTING ESSENTIALLY OF A DRY MIXTURE OF: A. ABOUT 100 PARTS BY WEIGHT OF AN INTIMATE CO-DIRED BLEND OF A MINOR BUT EFFECTIVE PORTION OF LOCUST BEAM GUM AND A MAJOR PORTION OF TRICALCIUM PHOSPHATE, B. UP TO ABOUT 200 PARTS OF GRANULAR TRICALCIUM PHOSPHATE, C. LOCUST BEAM GUM AS A LUBRICATING AGENT AND DISINTEGRATING AGENT IN AN AMOUNT OF FROM ABOUT 1 TO ABOUT 7 WEIGHT PER CENT, BASED UPON SAID CO-DIRED BLEND, AND FROM ABOUT 3 TO ABOUT 7 WEIGHT PER CENT, BASED UPON THE COBINED WEIGHT OF SAID CO-DRIED BLEND AND GRANULAR TRICALCIUM PHOSPHATE, AND D. A PHARMACEUTICALLY-ACCEPTABLE ACIDIC MATERIAL AS AN AUXILLIARY DISINTEGRATING AGENT IN AN AMOUNT OF FROM ABOUT 1 TO ABOUT 7 WEIGHT PER CENT, BASED UPON SAID CO-DRIED BLEND, AND FROM ABOUT 1 TO ABOUT 3 WEIGHT PERCENT, BASED UPON THE COMBINED WEIGHT OF SAID CO-DRIED BLEND AND GRANULAR TRICALCIUM PHOSPHATE.
Claim 2
Dependent Claim
160 words
A PARTICULATE COMPOSITION USEFUL AS A DIRECT COMPRESSION VEHICLE FOR FORMING TABLETS CONSISTING ESSENTIALLY OF A DRY MIXTURE OF: A. ABOUT 100 PARTS BY WEIGHT OF AN INTIMATE CO-DIRED BLEND OF A MINOR BUT EFFECTIVE PORTION OF LOCUST BEAM GUM AND A MAJOR PORTION OF TRICALCIUM PHOSPHATE, B. UP TO ABOUT 200 PARTS OF GRANULAR TRICALCIUM PHOSPHATE, C. LOCUST BEAM GUM AS A LUBRICATING AGENT AND DISINTEGRATING AGENT IN AN AMOUNT OF FROM ABOUT 1 TO ABOUT 7 WEIGHT PER CENT, BASED UPON SAID CO-DIRED BLEND, AND FROM ABOUT 3 TO ABOUT 7 WEIGHT PER CENT, BASED UPON THE COBINED WEIGHT OF SAID CO-DRIED BLEND AND GRANULAR TRICALCIUM PHOSPHATE, AND D. A PHARMACEUTICALLY-ACCEPTABLE ACIDIC MATERIAL AS AN AUXILLIARY DISINTEGRATING AGENT IN AN AMOUNT OF FROM ABOUT 1 TO ABOUT 7 WEIGHT PER CENT, BASED UPON SAID CO-DRIED BLEND, AND FROM ABOUT 1 TO ABOUT 3 WEIGHT PERCENT, BASED UPON THE COMBINED WEIGHT OF SAID CO-DRIED BLEND AND GRANULAR TRICALCIUM PHOSPHATE.
Claim 3
Dependent Claim
38 words
A composition according to claim 1 wherein said acidic material is sElected from the group consisting of citric acid, 2-acetoxybenzoic acid, adipic acid, fumaric acid, succinic acid, malic acid, tartaric acid, ferrous sulfate, aluminum sulfate and monocalcium phosphate.
Claim 4
Dependent Claim
13 words
A composition according to claim 2 wherein said acidic material is citric acid.
Claim 5
Dependent Claim
119 words
A particulate composition useful as a direct compression vehicle for forming tablets consisting essentially of: a. from about 30 to about 90 parts by weight of a particulate, intimate co-dried mixture of a minor but effective portion of locust bean gum and a major portion of tricalcium phosphate; b. up to 60 parts by weight of granular tricalcium phosphate, the combined weight of co-dried mixture and tricalcium phosphate being from about 90 to about 95 parts by weight; c. from about 3 to about 7 parts by weight of locust bean gum; and d. from about 2 to about 5 parts by weight of a powdered blend of approximately equal parts by weight of citric acid and tricalcium phosphate.
Claim 6
Dependent Claim
119 words
A particulate composition useful as a direct compression vehicle for forming tablets consisting essentially of: a. from about 30 to about 90 parts by weight of a particulate, intimate co-dried mixture of a minor but effective portion of locust bean gum and a major portion of tricalcium phosphate; b. up to 60 parts by weight of granular tricalcium phosphate, the combined weight of co-dried mixture and tricalcium phosphate being from about 90 to about 95 parts by weight; c. from about 3 to about 7 parts by weight of locust bean gum; and d. from about 2 to about 5 parts by weight of a powdered blend of approximately equal parts by weight of citric acid and tricalcium phosphate.
References Cited (Backward Citations)
US3042668A
Cited
US3134719A
Cited
US3424842A
Cited
US3627583A
Cited
US3639169A
Cited
US3639168A
Cited
US3821414A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-08-18 | 1979-02-17 | 1979-08-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-08-18 | 1983-02-17 | 1983-08-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-08-18 | 1987-02-17 | 1987-08-19 | $7700.00 | Window Closed / Lapsed |