US4948894A
Expired / Lapsed
US
⏱️ 0.0 years remaining
8-fluoro and 7, 8, 10-trifluoro-9-(substituted)-6-oxo-6H-benzo-(C)quinolizine-5-carboxylic acids
Assignee: Wyeth Holdings LLC
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Filing: 1989-12-06
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Granted: 1990-08-14
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Expires: 2009-12-06
Abstract
Abstract Novel substituted quinolinecarboxylic acid derivatives of the formula: ##STR1## wherein R 1 is hydrogen, alkali metal, alkaline earth metal or lower alkyl; R 2 is hydrogen, benzyl or alkyl (C 1 -C 3 ); X is hydrogen or fluoro; which have antibacterial activity, intermediates useful in the preparation of the compounds, methods of producing and using the compounds to treat bacterial infections in animals.
Inventors
- 👤 Daniel B. Moran
- 👤 Yang-I Lin
- 👤 Carl B. Ziegler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 16:52
CPC Classifications
C; C07; C07D; C07D455/00; C07D455/03; C07D455/04; C07D455/06
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
28 words
A compound of the formula: ##STR6## wherein R 1 is hydrogen, alkyl(C 1 -C 3 ), alkali metal, or alkaline earth metal and X is hydrogen or fluoro.
Claim 2
Dependent Claim
28 words
A compound of the formula: ##STR6## wherein R 1 is hydrogen, alkyl(C 1 -C 3 ), alkali metal, or alkaline earth metal and X is hydrogen or fluoro.
Claim 3
Dependent Claim
62 words
A process for producing compounds of the formula: ##STR7## wherein R 1 is hydrogen, alkyl(C 1 -C 3 ), alkali metal, or alkaline earth metal and X is hydrogen or fluoro, which comprises reacting ethyl 2-pyridyl acetate with lithium bis(trimethylsilyl)amide in tetrahydrofuran at -5° C. and adding the resultant mixture to either 2,4,5-trifluorobenzoyl chloride or tetrafluorobenzoyl chloride in tetrahydrofuran at -5° C.
Claim 4
Dependent Claim
62 words
A process for producing compounds of the formula: ##STR7## wherein R 1 is hydrogen, alkyl(C 1 -C 3 ), alkali metal, or alkaline earth metal and X is hydrogen or fluoro, which comprises reacting ethyl 2-pyridyl acetate with lithium bis(trimethylsilyl)amide in tetrahydrofuran at -5° C. and adding the resultant mixture to either 2,4,5-trifluorobenzoyl chloride or tetrafluorobenzoyl chloride in tetrahydrofuran at -5° C.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-08-13 | 1994-02-12 | 1994-08-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-08-13 | 1998-02-12 | 1998-08-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-08-13 | 2002-02-12 | 2002-08-14 | $7700.00 | Window Closed / Lapsed |