US4594347A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pyrrolo [3,2,1-ij]-quinoline carboxylic acid compound
Assignee: Otsuka Pharmaceutical Co Ltd
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Filing: 1984-01-24
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Granted: 1986-06-10
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Expires: 2004-01-24
Abstract
Abstract Benzo-heterocyclic compounds of the formula: ##STR1## wherein R 1 is a lower alkyl group; R 2 is a halogen atom or a group of the formula ##STR2## (wherein R 4 and R 5 combine together with the nitrogen atom to which they bind to form a 5- or 6-membered saturated heterocyclic group which may optionally contain an oxygen atom or nitrogen atom within the ring as an additional hetero atom and may also optionally have a substituent selected from a lower alkyl or hydroxy group on the hetero ring); R 3 is an amino or nitro group; X is a halogen atom; and n is an integer of 1 or 2, and a salt thereof, which have excellent antimicrobial activities and are useful as an antimicrobial agent, or as an intermediate for the preparation of an active compound.
Inventors
- 👤 Hiroshi Ishikawa
- 👤 Tetsuyuki Uno
- 👤 Hisashi Miyamoto
- 👤 Kazuyuki Nakagawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 20:15
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04; C07D471/06; A; A61; A61P; A61P31/00; A61P31/04; A61P31/06; C07D455/00; C07D455/03; C07D455/04
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
62 words
A benzo-heterocyclic compound of the formula: ##STR9## wherein R 1 is a lower alkyl group; R 2 is a piperazinyl group or a substituted piperazinyl group wherein the substituent is a lower alkyl group or a hydroxy group; R 3 is an amino group; X is a halogen atom; and n is an integer of 1, and a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
62 words
A benzo-heterocyclic compound of the formula: ##STR9## wherein R 1 is a lower alkyl group; R 2 is a piperazinyl group or a substituted piperazinyl group wherein the substituent is a lower alkyl group or a hydroxy group; R 3 is an amino group; X is a halogen atom; and n is an integer of 1, and a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
20 words
The compound of claim 1, wherein R 1 is methyl or ethyl; and X is a chlorine or fluorine atom.
Claim 4
Dependent Claim
25 words
The compound according to claim 1, wherein R 1 is methyl group, R 2 is a 4-lower alkyl substituted 1-piperazinyl group, and X is fluorine.
Claim 5
Dependent Claim
10 words
The compound according to claim 1, which is 8-fluoro-2-methyl-9-(4-methyl-1-piperazinyl)-7-amino-6-oxo-1,2-dihydro-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid.
Claim 6
Dependent Claim
80 words
An antimicrobial composition comprising an antimicrobially effective amount of a benzo-heterocyclic compound of the formula: ##STR10## wherein R 1 is a lower alkyl group; R 2 is a piperazinyl group or a substituted piperazinyl group wherein the substituent is a lower alkyl group or a hydroxy group; R 3 is an amino group; X is a halogen atom; and n is an integer of 1; and a pharmaceutically acceptable salt thereof in admixture with a pharmaceutically acceptable carrier or diluent.
Claim 7
Dependent Claim
80 words
An antimicrobial composition comprising an antimicrobially effective amount of a benzo-heterocyclic compound of the formula: ##STR10## wherein R 1 is a lower alkyl group; R 2 is a piperazinyl group or a substituted piperazinyl group wherein the substituent is a lower alkyl group or a hydroxy group; R 3 is an amino group; X is a halogen atom; and n is an integer of 1; and a pharmaceutically acceptable salt thereof in admixture with a pharmaceutically acceptable carrier or diluent.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-09 | 1989-12-09 | 1990-06-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-09 | 1993-12-09 | 1994-06-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-09 | 1997-12-09 | 1998-06-10 | $7700.00 | Window Closed / Lapsed |