US4931282A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pressure-sensitive medical sealant
Assignee: 3M Co
•
Filing: 1987-11-25
•
Granted: 1990-06-05
•
Expires: 2007-11-25
Abstract
Abstract A pressure-sensitive medical sealant composition comprising (a) a crosslinked, swellable polymeric matrix made from an N-vinyl lactam monomer and a multi-ethylenically unsaturated compound, wherein the ethylenic groups are vinyl groups, allyl groups or methallyl groups, which groups are bonded to nitrogen or oxygen atoms; (b) a plasticizer; and (c) an antimicrobial. The medical sealant is highly moisture vapor transmissive and is capable of incorporating large concentrations of iodine. The composition can be used in a variety of medical applications including as a teat plug, a wound or burn dressing, or as a sealant to seal junctions between medical instruments penetrating the skin and the skin. A method of preparing the medical sealant composition in a caulkable form is also disclosed.
Inventors
- 👤 Robert A. Asmus
- 👤 Daniel C. Duan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 11:05
CPC Classifications
A; A61; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/58; A61L24/00; A61L24/001; A61L24/0015; A61L24/04; A61L24/06; A61L2300/00; A61L2300/10; A61L2300/106; A61L2300/40; A61L2300/404; A61L2300/406; Y; Y10; Y10S; Y10S526/00; Y10S526/931
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
183 words
A medical sealant composition comprising: (a) a crosslinked, swellable polymeric matrix formed by a free-radical polymerization of at least one polymerizable monomeric species wherein at least 50 percent by weight of the monomeric component is comprised of one or more N-vinyl lactams, and a crosslinker which is a multi-ethylenically unsaturated compound with the ethylenic groups being vinyl, allyl, or methallyl groups bonded to nitrogen or oxygen atoms, said N-vinyl lactam monomer being present in a concentration of about 5 to 99.9 percent by weight of the polymeric matrix precursor and said crosslinker being present in a concentration of about 0.02 to 5.0 percent by weight of said N-vinyl lactam monomer; (b) a plasticizing solution present in a concentration of between about 55 and less than about 95 percent by weight of said medical sealant composition; and (c) an antimicrobial present in a concentration of between about 0.01 and 10 percent by weight of said medical sealant composition; which composition is formulated so as to have a T-Peel value of at least about 3 g/cm when measured on low density polyethylene, as described herein.
Claim 2
Dependent Claim
183 words
A medical sealant composition comprising: (a) a crosslinked, swellable polymeric matrix formed by a free-radical polymerization of at least one polymerizable monomeric species wherein at least 50 percent by weight of the monomeric component is comprised of one or more N-vinyl lactams, and a crosslinker which is a multi-ethylenically unsaturated compound with the ethylenic groups being vinyl, allyl, or methallyl groups bonded to nitrogen or oxygen atoms, said N-vinyl lactam monomer being present in a concentration of about 5 to 99.9 percent by weight of the polymeric matrix precursor and said crosslinker being present in a concentration of about 0.02 to 5.0 percent by weight of said N-vinyl lactam monomer; (b) a plasticizing solution present in a concentration of between about 55 and less than about 95 percent by weight of said medical sealant composition; and (c) an antimicrobial present in a concentration of between about 0.01 and 10 percent by weight of said medical sealant composition; which composition is formulated so as to have a T-Peel value of at least about 3 g/cm when measured on low density polyethylene, as described herein.
Claim 3
Dependent Claim
40 words
A composition in accordance with claim 1 wherein said multi-ethylenically unsaturated compound is selected from the group consisting of divinyl, diallyl and dimethallyl esters; divinyl, diallyl and dimethallyl amides; divinyl, diallyl and dimethallyl ethers; and divinyl, diallyl and dimethallyl ureas.
Claim 4
Dependent Claim
37 words
A composition in accordance with claim 1 wherein said multi-ethylenically unsaturated compound is a divinyl amide or a divinyl urea in an amount of from about 0.02 to about 0.5 percent by weight of said monomeric species.
Claim 5
Dependent Claim
52 words
A composition in accordance with claim 1 wherein said multi-ethylenically unsaturated compound is a divinyl, diallyl or dimethallyl ester; a diallyl or dimethallyl ether; a diallyl or dimethallyl amide; or a diallyl or dimethallyl urea in an amount of from about 0.05 to about 2 percent by weight of said monomeric species.
Claim 6
Dependent Claim
33 words
A composition in accordance with claim 1 wherein said multi-ethylenically unsaturated compound is a divinyl ether in an amount of from about 0.5 to about 5 percent by weight of said monomeric species.
Claim 7
Dependent Claim
14 words
A composition in accordance with claim 1 wherein the N-vinyl lactam monomer is N-vinyl-2-pyrrolidone.
Claim 8
Dependent Claim
23 words
A composition in accordance with claim 1 wherein said plasticizer is comprised of about 10 to 80 percent by weight glycerol in water.
Claim 9
Dependent Claim
29 words
A composition in accordance with claim 1 wherein said antimicrobial is selected from the group consisting of iodine, chlorhexidine gluconate, parachlorometaxylenol, zinc bacitracin, neomycin sulfate and polymyxin B sulfate.
Claim 10
Dependent Claim
12 words
A composition in accordance with claim 8 wherein said antimicrobial is iodine.
Claim 11
Dependent Claim
40 words
A composition in accordance with claim 1 wherein said polymeric matrix includes a polymerizable monomeric species selected from the group consisting of hydroxyalkyl acrylates and methacrylates; water soluble amines; water soluble hydrazine derivatives; and mono-olefinic sulfonic acids and their salts.
Claim 12
Independent Claim
222 words
A method of preparing a medical sealant composition, comprising the steps of (a) preparing a mixture comprising at least one polymerizable monomeric species, and a crosslinker which is a multiethylenically unsaturated compound wherein the ethylenic groups are vinyl groups, allyl groups, or methallyl groups bonded to nitrogen or oxygen atoms, wherein at least 50 percent by weight of the monomeric component is comprised of one or more N-vinyl lactams and said crosslinker is present in a concentration of about 0.02 to 5.0 percent by weight of said N-vinyl lactam monomer; (b) exposing said composition to sufficient energy to result in the formation of a crosslinked swellable polymeric matrix; (c) grinding said polymer into a powder having an average particle size of less than about 0.25 cm; (d) adding said powder to a plasticizer solution having an antimicrobial therein, said plasticizing solution being present in a concentration of between about 55 and less than about 95 percent by weight of said medical sealant composition, said antimicrobial being present in a concentration of between about 0.01 and 10 percent by weight of said medical sealant composition and said powder, plasticizing solution and antimicrobial being present in a concentration sufficient to provide said medical sealant composition with a T-Peel value of at least about 3 g/cm when measured on low density polyethylene, as described herein.
Claim 13
Independent Claim
222 words
A method of preparing a medical sealant composition, comprising the steps of (a) preparing a mixture comprising at least one polymerizable monomeric species, and a crosslinker which is a multiethylenically unsaturated compound wherein the ethylenic groups are vinyl groups, allyl groups, or methallyl groups bonded to nitrogen or oxygen atoms, wherein at least 50 percent by weight of the monomeric component is comprised of one or more N-vinyl lactams and said crosslinker is present in a concentration of about 0.02 to 5.0 percent by weight of said N-vinyl lactam monomer; (b) exposing said composition to sufficient energy to result in the formation of a crosslinked swellable polymeric matrix; (c) grinding said polymer into a powder having an average particle size of less than about 0.25 cm; (d) adding said powder to a plasticizer solution having an antimicrobial therein, said plasticizing solution being present in a concentration of between about 55 and less than about 95 percent by weight of said medical sealant composition, said antimicrobial being present in a concentration of between about 0.01 and 10 percent by weight of said medical sealant composition and said powder, plasticizing solution and antimicrobial being present in a concentration sufficient to provide said medical sealant composition with a T-Peel value of at least about 3 g/cm when measured on low density polyethylene, as described herein.
Claim 14
Independent Claim
224 words
A method of preparing a medical sealant composition, comprising the steps of (a) preparing a mixture comprising at least one polymerizable monomeric species, and a crosslinker which is a multiethylenically unsaturated compound wherein the ethylenic groups are vinyl groups, allyl groups, or methallyl groups bonded to nitrogen or oxygen atoms, and an antimicrobial, wherein at least 50 percent by weight of the monomeric component is comprised of one or more N-vinyl lactams and said crosslinker is present in a concentration of about 0.02 to 5.0 percent by weight of said N-vinyl lactam monomer, and said antimicrobial being present in a concentration sufficient to provide the resultant medical sealant composition with about 0.01 to 10 percent by weight antimicrobial; (b) exposing said composition to sufficient energy to result in the formation of a crosslinked swellable polymeric matrix; (c) grinding said polymer into a powder having an average particle size of less than about 0.25 cm; (d) adding said powder to a plasticizer solution, said plasticizing solution being present in a concentration of between about 55 and less than about 95 percent by weight of said medical sealant composition, and said powder and plasticizing solution being present in a concentration sufficient to provide said medical sealant composition with a T-Peel value of at least about 3 g/cm when measured on low density polyethylene, as described herein.
Claim 15
Independent Claim
224 words
A method of preparing a medical sealant composition, comprising the steps of (a) preparing a mixture comprising at least one polymerizable monomeric species, and a crosslinker which is a multiethylenically unsaturated compound wherein the ethylenic groups are vinyl groups, allyl groups, or methallyl groups bonded to nitrogen or oxygen atoms, and an antimicrobial, wherein at least 50 percent by weight of the monomeric component is comprised of one or more N-vinyl lactams and said crosslinker is present in a concentration of about 0.02 to 5.0 percent by weight of said N-vinyl lactam monomer, and said antimicrobial being present in a concentration sufficient to provide the resultant medical sealant composition with about 0.01 to 10 percent by weight antimicrobial; (b) exposing said composition to sufficient energy to result in the formation of a crosslinked swellable polymeric matrix; (c) grinding said polymer into a powder having an average particle size of less than about 0.25 cm; (d) adding said powder to a plasticizer solution, said plasticizing solution being present in a concentration of between about 55 and less than about 95 percent by weight of said medical sealant composition, and said powder and plasticizing solution being present in a concentration sufficient to provide said medical sealant composition with a T-Peel value of at least about 3 g/cm when measured on low density polyethylene, as described herein.
Claim 16
Dependent Claim
30 words
A caulkable medical sealant prepared according to the method of claim 11 wherein the amount of said N-vinyl lactam monomer is about 5-45 percent by weight of said sealant composition.
Claim 17
Dependent Claim
30 words
A caulkable medical sealant prepared according to the method of claim 12 wherein the amount of said N-vinyl lactam monomer is about 5-45 percent by weight of said sealant composition.
Claim 18
Dependent Claim
32 words
A wound or burn dressing laminate comprising a layer of the composition of claim 1 and a layer of a moisture vapor permeable backing sheet suitable for use in a surgical dressing.
Claim 19
Dependent Claim
28 words
The wound or burn dressing of claim 15, wherein said N-vinyl lactam monomer is present in a concentration of about 5-45 percent by weight of said sealant composition.
Claim 20
Dependent Claim
28 words
A medical sealant composition in accordance with claim 1 wherein at least 90 percent by weight of the monomeric component is comprised of one or more N-vinyl lactams.
Claim 21
Dependent Claim
26 words
A medical sealant composition in accordance with claim 1 wherein 100 percent by weight of the monomeric component is comprised of one or more N-vinyl lactams.
References Cited (Backward Citations)
US3220960A
Cited
US3252995A
Cited
US3294765A
Cited
US3551556A
Cited
US3689439A
Cited
US3907720A
Cited
US3928255A
Cited
GB1511563A
Cited
US4058491A
Cited
US4300820A
Cited
US4364929A
Cited
US4310509A
Cited
US4323557A
Cited
US4554924A
Cited
US4367297A
Cited
US4543371A
Cited
US4436887A
Cited
GB2115431A
Cited
EP0107376A1
Cited
US4621029A
Cited
US4584192A
Cited
US4676782A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-06-04 | 1993-12-04 | 1994-06-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-06-04 | 1997-12-04 | 1998-06-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-06-04 | 2001-12-04 | 2002-06-05 | $7700.00 | Window Closed / Lapsed |