US4543371A
Expired / Lapsed
US
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Polymeric compositions and hydrogels formed therefrom
Assignee: Novartis AG
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Filing: 1983-02-14
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Granted: 1985-09-24
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Expires: 2003-02-14
Abstract
Abstract The invention provides new hydrogel forming materials comprising synthetic, hydrophilic, aqueous-insoluble polymer networks formed by copolymerization of a hydrophilic dihydroxyalkyl acrylate or methacrylate, a substantially water insoluble alkyl acrylate or methacrylate, one or more additional hydrophilic comonomers selected from the group of vinylic monomers, acrylates, and methacrylates, and a cross-linking agent. The hydrogels are preferably used for the formation of contact lenses, but may also be used for drug and pesticides delivery devices; dialysis, ultrafiltration and reverse osmosis membranes; implants in surgery and dentistry; and the like.
Inventors
- 👤 Paul M. Gallop
- 👤 Donald R. Korb
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 10:36
CPC Classifications
A; A01; A01N; A01N25/00; A01N25/08; A01N25/10; A61; A61K; A61K6/00; A61K6/80; A61K6/884; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2027; B; B01; B01D; B01D71/00; B01D71/06; B01D71/40; B01D71/401; B01D71/4011; B29; B29D; B29D11/00; B29D11/02; B01D2323/00; B01D2323/30; B01D61/00; B01D61/02; B01D61/025; B01D61/14; B01D61/145
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
118 words
A hydrogel formed from a hydrophilic polymer comprising: a first monomer comprising a hydrophilic compound having the formula: ##STR10## wherein: R is hydrogen or methyl; and n is an integer from 1 to 4; a second monomer comprising a substantially insoluble acrylate or methacrylate selected from the group consisting of methyl acrylate, methyl methacrylate, ethyl acrylate, ethyl methacrylate, propyl acrylate, propyl methacrylate, isopropyl acrylate, isopropyl methacrylate, butyl acrylate and butyl methacrylate; and a third monomer selected from the group consisting of vinyl acetate, 3-buten-1-ol, 2-propen-1-ol, 5-hexenol, methyl vinyl ether, propyl vinyl ether, butyl 3-buten-1-ol ether, N-methyl vinyl amide, N-propyl vinyl amide, N-ethyl-3-butenzmide, vinyl pyrrolidone, 3-hydroxypropyl acrylate, 2-hydroxyethyl acrylate, 2-hydroxyethyl methacrylate, methacrylamide, N-methyl methacrylamide, N-N-dimethyl methacrylamide, and mixtures thereof.
Claim 2
Dependent Claim
118 words
A hydrogel formed from a hydrophilic polymer comprising: a first monomer comprising a hydrophilic compound having the formula: ##STR10## wherein: R is hydrogen or methyl; and n is an integer from 1 to 4; a second monomer comprising a substantially insoluble acrylate or methacrylate selected from the group consisting of methyl acrylate, methyl methacrylate, ethyl acrylate, ethyl methacrylate, propyl acrylate, propyl methacrylate, isopropyl acrylate, isopropyl methacrylate, butyl acrylate and butyl methacrylate; and a third monomer selected from the group consisting of vinyl acetate, 3-buten-1-ol, 2-propen-1-ol, 5-hexenol, methyl vinyl ether, propyl vinyl ether, butyl 3-buten-1-ol ether, N-methyl vinyl amide, N-propyl vinyl amide, N-ethyl-3-butenzmide, vinyl pyrrolidone, 3-hydroxypropyl acrylate, 2-hydroxyethyl acrylate, 2-hydroxyethyl methacrylate, methacrylamide, N-methyl methacrylamide, N-N-dimethyl methacrylamide, and mixtures thereof.
Claim 3
Dependent Claim
12 words
The hydrogel of claim 1 wherein said first monomer comprises 2,3-dihydroxypropyl methacrylate.
Claim 4
Dependent Claim
12 words
The hydrogel of claim 1 wherein said second monomer comprises methyl methacrylate.
Claim 5
Dependent Claim
20 words
The hydrogel of claim 1 wherein said third monomer comprises a compound selected from vinyl pyrrolidone, 2-hydroxyethyl acrylate or methacrylamide.
Claim 6
Dependent Claim
46 words
The hydrogel of claim 1 wherein said polymer further includes a cross-linking agent selected from the group consisting of, ethylene glycol dimethacrylate, propylene glycol dimethacrylate, ethylene glycol diacrylate, triethanolamine dimethacrylate, triethanolamine trimethacrylate, tartaric acid dimethacrylate, triethylene glycol dimethacrylate, and the dimethacrylate of bis-hydroxyethylacetamide, and glycidyl methacrylate.
Claim 7
Dependent Claim
37 words
The hydrogel of claim 1 wherein said first monomer comprises 2,3-dihydroxypropyl methacrylate, said second monomer comprises methyl methacrylate and said third monomer comprises a compound selected from the group consisting of vinyl pyrrolidone, 2-hydroxyethyl acrylate, and methacrylamide.
Claim 8
Dependent Claim
16 words
The hydrogel of claim 1 wherein said polymer further includes a cross-linking agent compriseing glycidyl methacrylate.
Claim 9
Dependent Claim
28 words
The hydrogel of claim 6 wherein said molar ratio of said first monomer to said second monomer is in the range of from about 1:1 to about 10:1.
Claim 10
Dependent Claim
35 words
The hydrogel of claim 6 wherein said third monomer comprises vinyl pyrrolidone that is present in a molar ratio of 1:1 to 1.0:0.2 when compared to the total moles of said first and second monomers.
Claim 11
Dependent Claim
33 words
The hydrogel of claim 6 wherein said third monomer comprises methacrylamide that is present in a molar ratio of 1:1 1.0:0.2 when compared to the total moles of said first and second monomers.
Claim 12
Dependent Claim
35 words
The hydrogel of claim 6 wherein said third monomer comprises 2-hydroxyethyl acrylate that is present in a molar ratio of 1:1 to 1.0:0.2 when compared to the total moles of said first and second monomers.
Claim 13
Dependent Claim
29 words
The hydrogel of any one of claims 1 through 11 wherein said polymer comprises water of hydration in an amount of from about 35 to about 50 weight percent.
Claim 14
Dependent Claim
28 words
The hydrogel of any one of claims 1 through 11 wherein said polymer has a Shore A durometer type A-2 reading of from about 40 to about 50.
Claim 15
Dependent Claim
27 words
The hydrogel of any one of claims 1 through 11 wherein said polymer when hydrated exhibits a linear expansion of from about 15 to about 25 percent.
Claim 16
Dependent Claim
15 words
A shaped article made from the hydrogel of any one of claims 1 through 11.
Claim 17
Dependent Claim
15 words
A contact lens formed from the hydrogel of any one of claims 1 through 11.
References Cited (Backward Citations)
US4267295A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-09-23 | 1989-03-25 | 1989-09-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-09-23 | 1993-03-25 | 1993-09-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-09-23 | 1997-03-25 | 1997-09-24 | $7700.00 | Window Closed / Lapsed |