Patent US4922007A successfully refreshed from Google Patents.
US4922007A
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Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
Assignee: Merck and Co Inc
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Filing: 1989-06-09
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Granted: 1990-05-01
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Expires: 2009-06-09
Abstract
Abstract A process for the preparation of 4-amino-1-hydroxybutylidene-1, 1-bisphosphonic acid or salts thereof which comprises: (a) reacting 4-aminobutyric acid with a mixture of phosphorous acid and PC1 3 in the presence of methanesulfonic acid; and (b) recovering said 4-amino-1-hydroxybutylidene-1, 1-bisphosphonic acid or salts thereof.
Inventors
- 👤 Gerard R. Kieczykowski
- 👤 David G. Melillo
- 👤 Ronald B. Jobson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 10:59
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/3804; C07F9/3839; C07F9/3873; A; A61; A61P; A61P3/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
41 words
A process for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof which comprises: (a) reacting 4-aminobutyric acid with a mixture of phosphorous acid and PCl 3 in the presence of methanesulfonic acid; and (b) recovering said 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof.
Claim 2
Dependent Claim
41 words
A process for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof which comprises: (a) reacting 4-aminobutyric acid with a mixture of phosphorous acid and PCl 3 in the presence of methanesulfonic acid; and (b) recovering said 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof.
Claim 3
Dependent Claim
20 words
The process of claim 1 wherein said reaction is conducted at a temperature of from 45° C. to 125° C.
Claim 4
Dependent Claim
17 words
The process of claim 2 wherein said reaction is conducted at a temperature of about 65° C.
Claim 5
Dependent Claim
23 words
The process of claim 3 wherein sufficient sodium hydroxide is added to the reaction mixture and 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid monosodium salt trihydrate is recovered.
Claim 6
Dependent Claim
10 words
The process of claim 3 wherein 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid is recovered.
References Cited (Backward Citations)
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Cited
US4267108A
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US4327039A
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US4407761A
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US4304734A
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US4621077A
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US4639338A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-04-30 | 1993-10-30 | 1994-05-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-04-30 | 1997-10-30 | 1998-05-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-04-30 | 2001-10-30 | 2002-05-01 | $7700.00 | Window Closed / Lapsed |