US4054598A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-Hydroxy-3-amino-alkane-1,1-diphosphonic acids and salts
Assignee: Henkel AG and Co KGaA
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Filing: 1976-07-16
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Granted: 1977-10-18
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Expires: 1996-07-16
Abstract
Abstract 1-Hydroxy-3-amino-alkane-1,1-diphosphonic acids having the formula ##STR1## wherein X is a member selected from the group consisting of ##STR2## and ##STR3## wherein R 1 is a member selected from the group consisting of hydrogen and alkyl having 1 to 3 carbon atoms and R 2 is alkyl having 1 to 3 carbon atoms; as well as their water-soluble salts. The 1-hydroxy-3-amino-alkane-1,1-diphosphonic acids are excellent sequestering agents especially for alkaline earth metal ions. The compounds are useful in pharmaceutical preparations for treatment of disturbances of calcium or phosphate metabolism or cosmetic preparations such as toothpastes or mouthwashes for the prevention of tartar and plaque depositions.
Inventors
- 👤 Helmut Blum
- 👤 Karl-Heinz Worms
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 22:44
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/55; A61P; A61P3/00; A61P3/12; A61P3/14; A61Q; A61Q11/00; C; C02; C02F; C02F5/00; C02F5/08; C02F5/10; C02F5/14; C07; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/3804; C07F9/3839; C07F9/3873; C11; C11D; C11D3/00; C11D3/16; C11D3/36; C11D3/364; C23; C23F; C23F11/00; C23F11/08; C23F11/10; C23F11/167; C23F11/1676
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
58 words
A 1-hydroxy-3-amino-alkane-1,1-diphosphonic acid compound of the formula ##STR18## wherein X is a member selected from the group consisting of ##STR19## and ##STR20## wherein R 2 is alkyl having from 1 to 3 carbon atoms, and R 1 is a member selected from the group consisting of hydrogen and R 2 , and a non-toxic, pharmaceutically-acceptable water-soluble salt thereof.
Claim 2
Dependent Claim
58 words
A 1-hydroxy-3-amino-alkane-1,1-diphosphonic acid compound of the formula ##STR18## wherein X is a member selected from the group consisting of ##STR19## and ##STR20## wherein R 2 is alkyl having from 1 to 3 carbon atoms, and R 1 is a member selected from the group consisting of hydrogen and R 2 , and a non-toxic, pharmaceutically-acceptable water-soluble salt thereof.
Claim 3
Dependent Claim
11 words
The 1-hydroxy-3-amino-alkane-1,1-diphosphonic acid compound of claim 1 wherein X is ##STR21##
Claim 4
Dependent Claim
11 words
The 1-hydroxy-3-amino-alkane-1,1-diphosphonic acid compound of claim 1 wherein X is ##STR22##
Claim 5
Dependent Claim
11 words
The 1-hydroxy-3-amino-alkane-1,1-diphosphonic acid compound of claim 1 wherein X is ##STR23##
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-10-17 | 1981-04-18 | 1981-10-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-10-17 | 1985-04-18 | 1985-10-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-10-17 | 1989-04-18 | 1989-10-18 | $7700.00 | Window Closed / Lapsed |