US4304734A
Expired / Lapsed
US
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6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
Assignee: University of Chemistry and Technology
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Filing: 1980-10-16
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Granted: 1981-12-08
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Expires: 2000-10-16
Abstract
Abstract 6-amino-1-hydroxyhexylidene diphosphonic acid (I), salts of acid (I), and a process for the production thereof. Acid (I) has the summary formula ##STR1## Acid (I) and its salts are useful for pharmocologial purposes. In the production of acid (I) a mixture of phosphorous acid and phosphorous trichloride is reacted with the ε-aminocaproic acid or amide derived therefrom at a temperature from 50° to 150° C. The reaction can be carried out in the presence of an organic solvent, preferably chlorobenzene. Salt of the acid is produced by neutralization with one or two molecular equivalents of alkaline hydroxide, preferably sodium hydroxide.
Inventors
- 👤 Jiri Jary
- 👤 Veroslava Rihakova
- 👤 Alena Zobacova
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 09:06
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/3804; C07F9/3839; C07F9/3873
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
9 words
6-amino-1-hydroxyhexylidene diphosphonic acid of the summary formula (I) ##STR4##
Claim 2
Dependent Claim
9 words
6-amino-1-hydroxyhexylidene diphosphonic acid of the summary formula (I) ##STR4##
Claim 3
Dependent Claim
10 words
The mono-sodium salt of acid (I) according to claim 1.
Claim 4
Dependent Claim
10 words
The di-sodium salt of acid (I) according to claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-12-07 | 1985-06-08 | 1985-12-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-12-07 | 1989-06-08 | 1989-12-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-12-07 | 1993-06-08 | 1993-12-08 | $7700.00 | Window Closed / Lapsed |