Patent US4919141A successfully refreshed from Google Patents.
US4919141A
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US
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Implantable electrochemical sensor
Assignee: INSTITUT fur DIABETESTECHNOLOGIE GEMEINNUTZIGE FORSCHUNGS - und ENTWICKLUNGSGESELLSCHAFT MBH
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Filing: 1988-01-04
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Granted: 1990-04-24
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Expires: 2008-01-04
Abstract
Abstract The implantable electrochemical sensor for amperometric measurements in body liquids comprises at least one measurement electrode formed as a platinum wire, a reference electrode tubularly surrounding the measurement electrode and possibly made up of several parts and made of stainless steel containing molybdenum as an alloying component. Furthermore, a layer of an immobilized enzyme, such as glucose oxidase, is disposed on the electrodes. The sensor is intended for use for the control of blood sugar and tissue sugar in diabetics and is suitable to be employed in a portable diagnostic and/or therapeutic apparatus.
Inventors
- 👤 Horst D. Zier
- 👤 Wolfgang Kerner
- 👤 Ernst F. Pfeiffer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 16:39
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/1468; A61B5/1486; A61B5/14865; A61B5/14542
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
69 words
Implantable sensor for amperometric measurements in body liquids, such as blood or tissue liquid, comprising a measurement electrode; a reference electrode tubularly surrounding the measurement electrode and made of a stainless steel containing molybdenum as an alloy component; and a layer of an immobilized enzyme being disposed on at least one end of the electrodes, wherein said at least one end is adapted for insertion into a body liquid.
Claim 2
Dependent Claim
69 words
Implantable sensor for amperometric measurements in body liquids, such as blood or tissue liquid, comprising a measurement electrode; a reference electrode tubularly surrounding the measurement electrode and made of a stainless steel containing molybdenum as an alloy component; and a layer of an immobilized enzyme being disposed on at least one end of the electrodes, wherein said at least one end is adapted for insertion into a body liquid.
Claim 3
Dependent Claim
34 words
Sensor according to claim 1, wherein the reference electrode comprises a steel with 16 to 20 weight-percent chromium, 9 to 13 weight-percent nickel, 1.5 to 4.5 weight-percent molybdenum, and at most 0.2 weight-percent carbon.
Claim 4
Dependent Claim
15 words
Sensor according to claim 1, wherein the molybdenum component amounts from 1.8 to 2.3 weight-percent.
Claim 5
Dependent Claim
25 words
Sensor according to claim 1, wherein the reference electrode contains as further alloy components niobium and/or titanium of a weight-percentage of less than about 1%.
Claim 6
Dependent Claim
96 words
Sensor according to claim 1, wherein the reference electrode is formed as a cannula and where the measurement electrode is embedded in a synthetic resin in an axial direction with the at least one end directed toward a tip of the cannula, and wherein a pinpoint of the cannula and said at least one end of the measurement electrode is covered with a membrane which is permeable to the body liquid and the glucose dissolved therein as well as to oxygen and which membrane is impermeable to the enzyme and which membrane consists of porous polyurethane.
Claim 7
Dependent Claim
106 words
Sensor according to claim 1, wherein the reference electrode is formed as a cannula with a pinpoint at the at least one end adapted for insertion into a body liquid, wherein the pinpoint of the cannula is covered with a membrane which is permeable to the body liquid and the glucose dissolved therein as well as to oxygen and which membrane is impermeable to the enzyme and which membrane consists of porous polyurethane, and wherein the measurement electrode is embedded in a synthetic resin in an axial direction with the at least one end directed toward the pinpoint of the cannula and covered with the enzyme.
Claim 8
Dependent Claim
22 words
Sensor according to claim 6, wherein at least two measurement electrodes, directed in parallel to each other, are disposed in the cannula.
Claim 9
Dependent Claim
26 words
Sensor according to claim 7, wherein the one end of the one measurement electrode is covered with the enzyme and wherein the enzyme is glucose oxidase.
Claim 10
Dependent Claim
27 words
Sensor according to claim 8, wherein the measurement electrodes are connected to a joint measurement line and wherein the measurement electrodes are formed by a platinum wire.
Claim 11
Dependent Claim
31 words
Sensor according to claim 8, wherein the measurement electrodes (14, 14') are connected to measurement lines separated from each other and wherein the measurement electrodes are formed by a gold wire.
Claim 12
Dependent Claim
43 words
Sensor according to claim 7, wherein the pinpoint of the cannula the at least one end of the measurement electrode and at least one part of a jacket face of the reference electrode forming the cannula are covered with a connected oxygen-permeable membrane.
Claim 13
Dependent Claim
35 words
Sensor according to claim 7, wherein at least two reference electrodes, electrically insulated against each other, are provided, of which reference electrodes, in each case, one is coordinated electrochemically to one or more measurement electrodes.
Claim 14
Dependent Claim
61 words
Sensor according to claim 12, wherein only one of the measurement electrodes is covered with enzyme, wherein at least one reference electrode comprises stainless steel with molybdenum as an alloying component, and wherein at least one reference electrode coordinated to a measurement electrode without enzyme coating comprises a material selected from the group consisting of silver, silver/silver chloride and mixtures thereof.
Claim 15
Dependent Claim
41 words
Sensor according to claim 12, wherein the reference electrodes comprise partially cylindrical shells having a seam which shells supplement themselves to a tube-shaped cannula and which are connected to each other at their seam by way of an insulating synthetic resin.
Claim 16
Dependent Claim
33 words
Sensor according to claim 7, wherein the at least one end of only one of the measurement electrodes is fully or partially covered with the enzyme and wherein the enzyme is glucose oxidase.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-04-23 | 1993-10-23 | 1994-04-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-04-23 | 1997-10-23 | 1998-04-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-04-23 | 2001-10-23 | 2002-04-24 | $7700.00 | Window Closed / Lapsed |