US4253456A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Artificial endocrinal gland
Assignee: Dr Eduard Fresenius Chemisch Pharmazeutische Industrie KG Apparatebau KG
•
Filing: 1978-08-21
•
Granted: 1981-03-03
•
Expires: 1998-08-21
Abstract
Abstract An artificial endocrinal gland comprises a blood dialyzer for transferring part of the blood to a measuring liquid in a separate circuit, an analyzer for quantatively determining this part and producing in the measuring liquid conversion products compatible to the patient's metabolism, a controller responsive to the analyzer and a device for supplying quantities of hormone to the patient's body under the control of the controller.
Inventors
- 👤 Johannes G. Schindler
- 👤 Wilfred Schal
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 04:06
CPC Classifications
F; F04; F04B; F04B43/00; F04B43/12; F04B43/1215; A; A61; A61M; A61M1/00; A61M1/36; A61M5/00; A61M5/14; A61M5/168; A61M5/172; A61M5/1723; A61M1/14; A61M1/16; A61M1/1678; Y; Y10; Y10S; Y10S128/00; Y10S128/13
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
226 words
A system intended for use in a patient for simulating an endocrinal gland by transferring a component of the flowing blood from said patient being monitored and treated into a measuring fluid flow path, comprising: (a) means for providing a constant flow of measuring fluid in a closed path, said measuring fluid not being consumed or diluted during measurement in said measuring fluid flow path; (b) dialyzing means coupled to said flowing blood and having a semipermeable membrane, said membrane permitting a component of said blood being monitored to be transferred to said measuring fluid in said measuring fluid flow path; (c) reactor means serially disposed in said measuring fluid flow path, said reactor means containing a compound in immobilized form for catalytic conversion of said component of said blood to be transferred to said measuring fluid flow path; (d) analyzer means serially coupled in said measuring fluid flow path for quantatatively determining the amount of said component of blood, said analyzer conversion products produced and appearing in said measuring fluid being compatable with the metabolism of said patient; (e) means coupled into said blood being monitored for supplying a material into said blood to modify the amount of said component appearing in said blood; and (f) controller means responsive to said analyzer means for controlling the quantity of said material supplied by said supplying means.
Claim 2
Independent Claim
226 words
A system intended for use in a patient for simulating an endocrinal gland by transferring a component of the flowing blood from said patient being monitored and treated into a measuring fluid flow path, comprising: (a) means for providing a constant flow of measuring fluid in a closed path, said measuring fluid not being consumed or diluted during measurement in said measuring fluid flow path; (b) dialyzing means coupled to said flowing blood and having a semipermeable membrane, said membrane permitting a component of said blood being monitored to be transferred to said measuring fluid in said measuring fluid flow path; (c) reactor means serially disposed in said measuring fluid flow path, said reactor means containing a compound in immobilized form for catalytic conversion of said component of said blood to be transferred to said measuring fluid flow path; (d) analyzer means serially coupled in said measuring fluid flow path for quantatatively determining the amount of said component of blood, said analyzer conversion products produced and appearing in said measuring fluid being compatable with the metabolism of said patient; (e) means coupled into said blood being monitored for supplying a material into said blood to modify the amount of said component appearing in said blood; and (f) controller means responsive to said analyzer means for controlling the quantity of said material supplied by said supplying means.
Claim 3
Dependent Claim
37 words
A system for simulating an endrocrinal gland according to claim 1 wherein said reactor means comprises an enzyme reactor and said compound for catalytic conversion comprises an enzyme bonded at the surface of a polymeric carrier material.
Claim 4
Dependent Claim
45 words
A system for simulating an endocrinal gland according to claim 1 further including a switching means coupled in said measuring fluid flow path for providing periodic calibration of said analyzer means with a calibration liquid while blocking off circulation of said measuring fluid flow path
Claim 5
Dependent Claim
47 words
A system for simulating an endocrinal gland according to claim 3, wherein said means for providing a constant circulation of said measuring fluid includes pump means, said pump means being activated by a motor, said motor also controlling said switching means provided in said fluid flow path.
Claim 6
Dependent Claim
33 words
A system for simulating an endocrinal gland according to claim 1 further including optical monitoring devices for detecting blood in the measuring fluid and air in the fluid returned into said monitored blood.
Claim 7
Dependent Claim
44 words
A system for simulating an endocrinal gland according to claim 5 wherein said gland is a pancreas beta cell and said measuring fluid flow path includes an oxygenator, an enzyme reactor and an oxygen sensitive measuring probe arranged serially in said measuring fluid path.
Claim 8
Dependent Claim
55 words
A system for simulating an endocrinal gland according to claim 6 wherein said oxyginator is constructed as a roller pump with hoses for simultaneously permitting the passage of oxygen from the surrounding air into said measuring fluid by mechanical agitation of said hoses and circulating said measuring fluid in said closed measuring fluid flow path.
Claim 9
Independent Claim
243 words
A system intended for use in a patient for simulating an endocrinal gland by transferring a component of the flowing blood from said patient being monitored and treated into a measuring fluid flow path comprising: (a) dialyzing means coupled to said flowing blood and having a semipermeable membrane, said membrane permitting a component of said blood being monitored to be transferred to said measuring fluid in said measuring fluid flow path; (b) said measuring fluid flow path forming a closed path in which said measuring fluid is recirculating without any consumption of measuring fluid and is blocked off from any additional liquid supplied during measurement, said closed measuring path including: (i) means for providing a constant circulation of measuring fluid flow, (ii) reactor means serially coupled in said measuring fluid flow path, said reactor means containing a compound for catalytic conversion of said blood component to be transferred to said measuring fluid flow path, said compound being in immobilized form, and (iii) analyzer means serially coupled in said measuring fluid flow path for quantitatively determining the amount of said component of said blood within said measuring fluid flow path; (c) means coupled into said blood being monitored for supplying a material into said blood to modify the amount of said component of said blood being transferred to said measuring fluid flow path; and (d) controller means responsive to said analyzer means for controlling the quantity of said material supplied by said supplying means.
Claim 10
Independent Claim
243 words
A system intended for use in a patient for simulating an endocrinal gland by transferring a component of the flowing blood from said patient being monitored and treated into a measuring fluid flow path comprising: (a) dialyzing means coupled to said flowing blood and having a semipermeable membrane, said membrane permitting a component of said blood being monitored to be transferred to said measuring fluid in said measuring fluid flow path; (b) said measuring fluid flow path forming a closed path in which said measuring fluid is recirculating without any consumption of measuring fluid and is blocked off from any additional liquid supplied during measurement, said closed measuring path including: (i) means for providing a constant circulation of measuring fluid flow, (ii) reactor means serially coupled in said measuring fluid flow path, said reactor means containing a compound for catalytic conversion of said blood component to be transferred to said measuring fluid flow path, said compound being in immobilized form, and (iii) analyzer means serially coupled in said measuring fluid flow path for quantitatively determining the amount of said component of said blood within said measuring fluid flow path; (c) means coupled into said blood being monitored for supplying a material into said blood to modify the amount of said component of said blood being transferred to said measuring fluid flow path; and (d) controller means responsive to said analyzer means for controlling the quantity of said material supplied by said supplying means.
Claim 11
Dependent Claim
26 words
A system for simulating an endocrinal gland according to claim 8 wherein said quantitatively determining means includes a catalytic conversion of said component of said blood.
Claim 12
Independent Claim
180 words
A system intended for use in a patient for simulating an endocrinal gland by transferring a component of the flowing blood from said patient being monitored and treated into a measuring fluid flow path comprising: (a) means for providing a constant flow of measuring fluid in a closed path, said measuring fluid not being consumed or diluted during measurement in said measuring fluid flow path; (b) dialyzing means coupled to said flowing blood and having a semipermeable membrane, said membrane permitting a component of said blood being monitored to be transferred to said measuring fluid in said measuring fluid flow path; (c) reactor means serially coupled in said measuring fluid flow path, said reactor means containing a compound in immobilized form for catalytic conversion of said component of said blood to be transferred to said measuring fluid flow path; and (d) analyzer means serially coupled in said measuring fluid flow path for quantitatively determining the amount of said component of blood, said analyzer conversion products produced and appearing in aid meausring fluid being compatible with the metabolism of said patient.
Claim 13
Independent Claim
180 words
A system intended for use in a patient for simulating an endocrinal gland by transferring a component of the flowing blood from said patient being monitored and treated into a measuring fluid flow path comprising: (a) means for providing a constant flow of measuring fluid in a closed path, said measuring fluid not being consumed or diluted during measurement in said measuring fluid flow path; (b) dialyzing means coupled to said flowing blood and having a semipermeable membrane, said membrane permitting a component of said blood being monitored to be transferred to said measuring fluid in said measuring fluid flow path; (c) reactor means serially coupled in said measuring fluid flow path, said reactor means containing a compound in immobilized form for catalytic conversion of said component of said blood to be transferred to said measuring fluid flow path; and (d) analyzer means serially coupled in said measuring fluid flow path for quantitatively determining the amount of said component of blood, said analyzer conversion products produced and appearing in aid meausring fluid being compatible with the metabolism of said patient.
Claim 14
Dependent Claim
60 words
A system for simulating an endocrinal gland according to claim 10 further including: (d) means coupled in said blood being monitored for supplying a material into said blood to modify the amount of said component appearing in said blood; and (e) controller means responsive to said analyzer means for controlling the quantity of said material supplied by said supplying means.
References Cited (Backward Citations)
SU305410A1
Cited
SU232476A1
Cited
US3015331A
Cited
US3183908A
Cited
US3512517A
Cited
US3518982A
Cited
DE2017112A1
Cited
DE2152355A1
Cited
DE2261247A1
Cited
SU435826A1
Cited
US3838682A
Cited
DE2601893A1
Cited
US4060485A
Cited
US4081372A
Cited
US4055175A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-03-02 | 1984-09-01 | 1985-03-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-03-02 | 1988-09-01 | 1989-03-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-03-02 | 1992-09-01 | 1993-03-03 | $7700.00 | Window Closed / Lapsed |