Patent US3947567A successfully refreshed from Google Patents.
Patent US4917951A successfully refreshed from Google Patents.
US4917951A
Expired / Lapsed
US
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Lipid vesicles formed of surfactants and steroids
Assignee: Novavax Inc
•
Filing: 1987-11-24
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Granted: 1990-04-17
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Expires: 2007-11-24
Abstract
Abstract Disclosed is a method of making lipid vesicles of a steroid and surfactants which do not form vesicles in the absence of the steroid. The surfactants are polyoxyethylene derivatives of 16-20 carbon ethers and amines.
Inventors
- 👤 Donald F. H. Wallach
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 08:01
CPC Classifications
C; C11; C11D; C11D17/00; C11D17/0008; C11D17/0026; A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K9/1271; A61K9/1272; A61K9/1277; Y; Y10; Y10S; Y10S436/00; Y10S436/829; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
95 words
A multilamellar lipid vesicle formed of surfactant materials which do not form vesicles in the absence of a steroid, said multilamellar lipid vesicle consisting essentially of a single surfactant selected from the group consisting of: polyoxyethylene (n) cetyl ethers where n ranges from 5-10; polyoxyethylene (x) stearyl ethers where x ranges from 2-10; polyoxyethylene (y) oleyl ethers where y ranges from 2-10; polyoxyethylene (z) linoleyl ethers where z ranges from 2-10; polyoxyethylene (s) eicosamonoenoyl ethers where s ranges from 2-10; polyoxyethylene (t) eicosadienoyl ethers where t ranges from 2-10; and about 20-50% of a steroid.
Claim 2
Dependent Claim
95 words
A multilamellar lipid vesicle formed of surfactant materials which do not form vesicles in the absence of a steroid, said multilamellar lipid vesicle consisting essentially of a single surfactant selected from the group consisting of: polyoxyethylene (n) cetyl ethers where n ranges from 5-10; polyoxyethylene (x) stearyl ethers where x ranges from 2-10; polyoxyethylene (y) oleyl ethers where y ranges from 2-10; polyoxyethylene (z) linoleyl ethers where z ranges from 2-10; polyoxyethylene (s) eicosamonoenoyl ethers where s ranges from 2-10; polyoxyethylene (t) eicosadienoyl ethers where t ranges from 2-10; and about 20-50% of a steroid.
Claim 3
Dependent Claim
12 words
The lipid vesicle of claim 1 wherein said steroid comprises a sterol.
Claim 4
Dependent Claim
20 words
The lipid vesicle of claim 1 wherein said steroid is selected from a group consisting of cholesterol and hydrocortisone acetate.
Claim 5
Dependent Claim
12 words
The lipid vesicle of claim 1 further comprising a charge producing amphiphile.
Claim 6
Dependent Claim
96 words
A multilamellar lipid vesicle formed of surfactant materials which do not form these vesicles in the absence of a steroid, said multilamellar lipid vesicle consisting essentially of a single surfactant selected from the group consisting of: polyoxyethylene (n') cetyl amines where n' ranges from 5-10; polyoxyethylene (x') stearyl amines where x' ranges from 5-10; polyoxyethylene (y') oleyl amines where y' ranges from 5-10; polyoxyethylene (z') linoleyl amines where z' ranges from 5-10; polyoxyethylene (s') eicosamonoenoyl amines where s' ranges from 5-10; polyoxyethylene (t') eicosadienoyl amines where t' ranges from 5-10; and about 20-50% of a steroid.
Claim 7
Dependent Claim
96 words
A multilamellar lipid vesicle formed of surfactant materials which do not form these vesicles in the absence of a steroid, said multilamellar lipid vesicle consisting essentially of a single surfactant selected from the group consisting of: polyoxyethylene (n') cetyl amines where n' ranges from 5-10; polyoxyethylene (x') stearyl amines where x' ranges from 5-10; polyoxyethylene (y') oleyl amines where y' ranges from 5-10; polyoxyethylene (z') linoleyl amines where z' ranges from 5-10; polyoxyethylene (s') eicosamonoenoyl amines where s' ranges from 5-10; polyoxyethylene (t') eicosadienoyl amines where t' ranges from 5-10; and about 20-50% of a steroid.
Claim 8
Dependent Claim
12 words
The lipid vesicle of claim 5 wherein said steroid comprises a sterol.
Claim 9
Dependent Claim
20 words
The lipid vesicle of claim 5 wherein said steroid is selected from the group consisting of cholesterol and hydrocortisone acetate.
Claim 10
Dependent Claim
12 words
The lipid vesicle of claim 5 further comprising a charge producing amphiphile.
References Cited (Backward Citations)
US3372201A
Cited
US3957971A
Cited
GB1539625A
Cited
US4772471A
Cited
US4133874A
Cited
US4217344A
Cited
US4356167A
Cited
US4247411A
Cited
US4377567A
Cited
US4241046A
Cited
US4666711A
Cited
US4348329A
Cited
EP0032578A1
Cited
GB2078543A
Cited
GB2079179A
Cited
US4731210A
Cited
US4684625A
Cited
US4536324A
Cited
US4551288A
Cited
US4564599A
Cited
US4485054A
Cited
JPS59106423A
Cited
US4608211A
Cited
DE3410602A1
Cited
US4725442A
Cited
GB2147263A
Cited
WO1985001440A1
Cited
US4692433A
Cited
US4695554A
Cited
US4610868A
Cited
US4619913A
Cited
GB2166107A
Cited
JPS61207324A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-04-16 | 1993-10-16 | 1994-04-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-04-16 | 1997-10-16 | 1998-04-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-04-16 | 2001-10-16 | 2002-04-17 | $7700.00 | Window Closed / Lapsed |