US4917951A
Expired / Lapsed
US
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Lipid vesicles formed of surfactants and steroids
Assignee: Novavax Inc
•
Filing: 1987-11-24
•
Granted: 1990-04-17
•
Expires: 2007-11-24
Abstract
Abstract Disclosed is a method of making lipid vesicles of a steroid and surfactants which do not form vesicles in the absence of the steroid. The surfactants are polyoxyethylene derivatives of 16-20 carbon ethers and amines.
Inventors
- 👤 Donald F. H. Wallach
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 04:58
CPC Classifications
C; C11; C11D; C11D17/00; C11D17/0008; C11D17/0026; A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K9/1271; A61K9/1272; A61K9/1277; Y; Y10; Y10S; Y10S436/00; Y10S436/829; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
95 words
A multilamellar lipid vesicle formed of surfactant materials which do not form vesicles in the absence of a steroid, said multilamellar lipid vesicle consisting essentially of a single surfactant selected from the group consisting of: polyoxyethylene (n) cetyl ethers where n ranges from 5-10; polyoxyethylene (x) stearyl ethers where x ranges from 2-10; polyoxyethylene (y) oleyl ethers where y ranges from 2-10; polyoxyethylene (z) linoleyl ethers where z ranges from 2-10; polyoxyethylene (s) eicosamonoenoyl ethers where s ranges from 2-10; polyoxyethylene (t) eicosadienoyl ethers where t ranges from 2-10; and about 20-50% of a steroid.
Claim 2
Dependent Claim
95 words
A multilamellar lipid vesicle formed of surfactant materials which do not form vesicles in the absence of a steroid, said multilamellar lipid vesicle consisting essentially of a single surfactant selected from the group consisting of: polyoxyethylene (n) cetyl ethers where n ranges from 5-10; polyoxyethylene (x) stearyl ethers where x ranges from 2-10; polyoxyethylene (y) oleyl ethers where y ranges from 2-10; polyoxyethylene (z) linoleyl ethers where z ranges from 2-10; polyoxyethylene (s) eicosamonoenoyl ethers where s ranges from 2-10; polyoxyethylene (t) eicosadienoyl ethers where t ranges from 2-10; and about 20-50% of a steroid.
Claim 3
Dependent Claim
12 words
The lipid vesicle of claim 1 wherein said steroid comprises a sterol.
Claim 4
Dependent Claim
20 words
The lipid vesicle of claim 1 wherein said steroid is selected from a group consisting of cholesterol and hydrocortisone acetate.
Claim 5
Dependent Claim
12 words
The lipid vesicle of claim 1 further comprising a charge producing amphiphile.
Claim 6
Dependent Claim
96 words
A multilamellar lipid vesicle formed of surfactant materials which do not form these vesicles in the absence of a steroid, said multilamellar lipid vesicle consisting essentially of a single surfactant selected from the group consisting of: polyoxyethylene (n') cetyl amines where n' ranges from 5-10; polyoxyethylene (x') stearyl amines where x' ranges from 5-10; polyoxyethylene (y') oleyl amines where y' ranges from 5-10; polyoxyethylene (z') linoleyl amines where z' ranges from 5-10; polyoxyethylene (s') eicosamonoenoyl amines where s' ranges from 5-10; polyoxyethylene (t') eicosadienoyl amines where t' ranges from 5-10; and about 20-50% of a steroid.
Claim 7
Dependent Claim
96 words
A multilamellar lipid vesicle formed of surfactant materials which do not form these vesicles in the absence of a steroid, said multilamellar lipid vesicle consisting essentially of a single surfactant selected from the group consisting of: polyoxyethylene (n') cetyl amines where n' ranges from 5-10; polyoxyethylene (x') stearyl amines where x' ranges from 5-10; polyoxyethylene (y') oleyl amines where y' ranges from 5-10; polyoxyethylene (z') linoleyl amines where z' ranges from 5-10; polyoxyethylene (s') eicosamonoenoyl amines where s' ranges from 5-10; polyoxyethylene (t') eicosadienoyl amines where t' ranges from 5-10; and about 20-50% of a steroid.
Claim 8
Dependent Claim
12 words
The lipid vesicle of claim 5 wherein said steroid comprises a sterol.
Claim 9
Dependent Claim
20 words
The lipid vesicle of claim 5 wherein said steroid is selected from the group consisting of cholesterol and hydrocortisone acetate.
Claim 10
Dependent Claim
12 words
The lipid vesicle of claim 5 further comprising a charge producing amphiphile.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-04-16 | 1993-10-16 | 1994-04-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-04-16 | 1997-10-16 | 1998-04-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-04-16 | 2001-10-16 | 2002-04-17 | $7700.00 | Window Closed / Lapsed |