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US4909256A
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Transdermal vapor collection method and apparatus
Assignee: United States Department of the Army
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Filing: 1987-11-16
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Granted: 1990-03-20
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Expires: 2007-11-16
Abstract
Abstract A method for the non-invasive, continuous collection of substances which transdermally migrate to and vaporize at the surface of the skin of a subject comprises providing a binding reservoir material juxtaposed at the surface of the skin of a subject, and continuously maintaining the binding reservoir material in a substantially airtight relation with the skin surface over an entire collection period. The apparatus comprises a binding reservoir material and means for continuously maintaining the binding reservoir material juxtaposed at the skin surface of the subject in a substantially airtight relation wiht the skin surface.
Inventors
- 👤 Carl C. Peck
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 22:03
CPC Classifications
A; A61; A61B; A61B10/00; A61B10/0045; A61B10/0064; A61B5/00; A61B5/42; A61B5/4261; A61B5/4283; G; G01; G01N; G01N33/00; G01N33/48; A61B2010/0009
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
136 words
A method for the non-invasive continuous collection of substances which transdermally migrate to and vaporize at tee surface of the skin of a subject, comprising (a) providing a binding reservoir material juxtaposed at the surface of the skin of the subject, (b) continuously maintaining the binding reservoir material in a substantially airtight relation with the skin surface over an entire collection period, whereby substances which have migrated to and vaporized at the skin surface are collected in the binding reservoir material and are prevented from escaping into the environment or migrating back into the skin, (c) removing the binding reservoir material from the skin surface, and (d) immersing the binding reservoir of step (c) in a predetermined quantity of organic solvent, whereby the collected vapors are transferred from the binding reservoir material to the organic solvent.
Claim 2
Independent Claim
136 words
A method for the non-invasive continuous collection of substances which transdermally migrate to and vaporize at tee surface of the skin of a subject, comprising (a) providing a binding reservoir material juxtaposed at the surface of the skin of the subject, (b) continuously maintaining the binding reservoir material in a substantially airtight relation with the skin surface over an entire collection period, whereby substances which have migrated to and vaporized at the skin surface are collected in the binding reservoir material and are prevented from escaping into the environment or migrating back into the skin, (c) removing the binding reservoir material from the skin surface, and (d) immersing the binding reservoir of step (c) in a predetermined quantity of organic solvent, whereby the collected vapors are transferred from the binding reservoir material to the organic solvent.
Claim 3
Dependent Claim
23 words
A method as defined by claim 1, wherein said providing step includes providing said binding reservoir material in a solid or semi-solid form.
Claim 4
Dependent Claim
44 words
A method as defined by claim 1, wherein said providing step includes providing a binding reservoir material selected from the group consisting of charcoal, molecular sieve materials, silica gels, silica gels modified with aromatic or aliphatic group-containing silanes, ion exchange resins and chelating agents.
Claim 5
Dependent Claim
23 words
A method as defined by claim 1, wherein said providing step includes providing said binding reservoir material impregnated on an inert carrier member.
Claim 6
Dependent Claim
25 words
A method as defined by claim 4, wherein said providing step includes providing said binding reservoir material impregnated on a carrier made of polytetrafluoroethylene material.
Claim 7
Dependent Claim
30 words
A method as defined by claim 1, wherein the binding reservoir material is maintained in a substantially airtight relation with the skin surface by an airtight, flexible, adhesive cover means.
Claim 8
Dependent Claim
51 words
A method as defined by claim 6, wherein said maintaining step includes employing cover means made of a material selected from metal foils and impermeable plastic films, at least a portion of which includes an adhesive coating to maintain said binding reservoir material in substantially airtight relation with the skin surface.
Claim 9
Dependent Claim
22 words
A method as defined by claim 1, wherein the skin surface is cleaned prior to providing the binding reservoir material juxtaposed thereto.
Claim 10
Independent Claim
107 words
An apparatus for the non-invasive, continuous collection of substances which transdermally migrate to and vaporize at the surface of the skin of a subject, comprising (a) a fluid-free binding reservoir material, and (b) means for continuously maintaining the fluid-free binding reservoir material juxtaposed at the surface of the skin of the subject in a substantially airtight relation with the skin surface over an entire collection period, said airtight relation being sufficient to ensure that when substances migrate to and vaporize at the skin surface they are collected in the fluid-free binding reservoir material and are prevented from escaping into the environment or migrating back into the skin.
Claim 11
Independent Claim
107 words
An apparatus for the non-invasive, continuous collection of substances which transdermally migrate to and vaporize at the surface of the skin of a subject, comprising (a) a fluid-free binding reservoir material, and (b) means for continuously maintaining the fluid-free binding reservoir material juxtaposed at the surface of the skin of the subject in a substantially airtight relation with the skin surface over an entire collection period, said airtight relation being sufficient to ensure that when substances migrate to and vaporize at the skin surface they are collected in the fluid-free binding reservoir material and are prevented from escaping into the environment or migrating back into the skin.
Claim 12
Dependent Claim
19 words
An apparatus as defined by claim 9, wherein the binding reservoir material is in a solid or semi-solid form.
Claim 13
Dependent Claim
40 words
An apparatus as defined in claim 9, wherein the binding reservoir material is selected from the group consisting of charcoal, molecular sieve materials, silica gels, silica gels modified with aromatic or aliphatic group-containing silanes, ion exchange resins and chelating agents.
Claim 14
Dependent Claim
19 words
An apparatus as defined by claim 9, wherein the binding reservoir material is impregnated on an inert carrier member.
Claim 15
Dependent Claim
17 words
An apparatus as defined by claim 12, wherein the carrier member is formed of a polytetrafluoroethylene material.
Claim 16
Dependent Claim
33 words
An apparatus as defined by claim 9, wherein the means for continuously maintaining the binding reservoir material in a substantially airtight relation with the skin surface comprises an airtight, flexible, adhesive cover means.
Claim 17
Dependent Claim
43 words
An apparatus as defined by claim 14, wherein the cover means is formed from a material selected from metal foils and impermeable plastic films, and at least a portion of the cover means includes an adhesive coating for adhering to the skin surface.
Claim 18
Dependent Claim
49 words
An apparatus as defined by claim 9, further including a removable impermeable cover means covering the portion of the binding reservoir material adapted for juxtaposition at the skin surface, which cover is adapted to be removed from the apparatus prior to use for the collection of transdermally migrating vapors.
Claim 19
Dependent Claim
25 words
An apparatus as defined by claim 16, wherein the removable cover means is formed from a material selected from metal foils and impermeable plastic films.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-03-19 | 1993-09-18 | 1994-03-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-03-19 | 1997-09-18 | 1998-03-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-03-19 | 2001-09-18 | 2002-03-20 | $7700.00 | Window Closed / Lapsed |