US4883534A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Benzoin antimicrobial dental varnishes
Assignee: 142116 ONTARIO Inc
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Filing: 1987-06-18
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Granted: 1989-11-28
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Expires: 2007-06-18
Abstract
Abstract A composition for treating dental infections, e.g. dental caries caused by Strep. mutans, comprises a varnish containing a dentally acceptable antimicrobial agent such as chlorhexidine acetate and benzoin gum in an orally acceptable liquid. The composition can be painted on teeth, allowed to dry thereon to give a transparent, translucent or tooth colored film which is effectively invisible but provides sustained release of the antimicrobial agent to the site of infection over a period of at least four days. The film can be removed at will, e.g. by application of the liquid varnish base. To sustain further the antimicrobial agent in situ and hinder its egress into the oral cavity, a sealing composition may be applied over the varnish layer. The sealing composition is preferably solvated polyurethane which cures by evaporation of solvent.
Inventors
- 👤 H. J. Sandham
- 👤 Thomas E. Balanyk
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 17:00
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/155; A61K6/00; A61K6/60; A61K6/69
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
104 words
A liquid varnish composition in an orally acceptable liquid vehicle means suitable for dental use and effective in combatting growth of caries-causing bacteria, said composition being capable of drying on teeth to yield at least initially a translucent, transparent or tooth colored film and capable of adherence to the dental infection site, said composition comprising an effective amount of at least one dentally acceptable antimicrobial means effective against Streptococcus mutans and an amount of benzoin effective to form said film and sufficient to permit effective communication of said antimicrobial means with the infection site and sustained release thereof when the composition is applied thereto.
Claim 2
Dependent Claim
104 words
A liquid varnish composition in an orally acceptable liquid vehicle means suitable for dental use and effective in combatting growth of caries-causing bacteria, said composition being capable of drying on teeth to yield at least initially a translucent, transparent or tooth colored film and capable of adherence to the dental infection site, said composition comprising an effective amount of at least one dentally acceptable antimicrobial means effective against Streptococcus mutans and an amount of benzoin effective to form said film and sufficient to permit effective communication of said antimicrobial means with the infection site and sustained release thereof when the composition is applied thereto.
Claim 3
Dependent Claim
12 words
The composition of claim 1 wherein the liquid vehicle means is ethanol.
Claim 4
Dependent Claim
23 words
The composition of claim 1 wherein the weight ratio of benzoin to antimicrobial means is in the approximate range of 10:1 to 1:10.
Claim 5
Dependent Claim
15 words
The composition of claim 1 including a plurality of antimicrobial means effective against Streptococcus mutans.
Claim 6
Dependent Claim
112 words
A liquid dental varnish composition suitable for painting onto teeth to combat oral infection by caries-causing bacteria, said composition consisting essentially of: an orally acceptable liquid vehicle; benzoin; and an effective amount of at least one dentally acceptable antimicrobial means effective against Streptococcus mutans compatible with the liquid vehicle and the benzoin; the liquid vehicle and the benzoin being present in suitable amounts such that the composition is capable of drying to form a solid transparent, translucent or tooth coloured coating on teeth to which the composition is applied and releasing at least one of said antimicrobial means over a sustained period of time into contact with infective sites on said teeth.
Claim 7
Dependent Claim
112 words
A liquid dental varnish composition suitable for painting onto teeth to combat oral infection by caries-causing bacteria, said composition consisting essentially of: an orally acceptable liquid vehicle; benzoin; and an effective amount of at least one dentally acceptable antimicrobial means effective against Streptococcus mutans compatible with the liquid vehicle and the benzoin; the liquid vehicle and the benzoin being present in suitable amounts such that the composition is capable of drying to form a solid transparent, translucent or tooth coloured coating on teeth to which the composition is applied and releasing at least one of said antimicrobial means over a sustained period of time into contact with infective sites on said teeth.
Claim 8
Dependent Claim
147 words
A two component liquid dental varnish composition-containing kit, the ingredients of which are collectively capable of combatting growth of caries-causing bacteria indigenous to the oral cavity, the kit comprising, in a first component, an effective amount of at least one dentally acceptable antimicrobial means effective against Streptococcus mutans in admixture with an amount of benzoin in an orally acceptable liquid vehicle means which is sufficient to permit effective communication of said antimicrobial means with a target site to which said first component may be applied, and to permit sustained release of said antimicrobial agent to said target site, and in a second distinct and separate component, an amount of a dentally acceptable, ethanol insoluble biodegradable polymeric sealant means in an orally acceptable liquid vehicle means, which is effective to seal the antimicrobial means and binder means ingredients of said first component in position over the target site.
Claim 9
Dependent Claim
147 words
A two component liquid dental varnish composition-containing kit, the ingredients of which are collectively capable of combatting growth of caries-causing bacteria indigenous to the oral cavity, the kit comprising, in a first component, an effective amount of at least one dentally acceptable antimicrobial means effective against Streptococcus mutans in admixture with an amount of benzoin in an orally acceptable liquid vehicle means which is sufficient to permit effective communication of said antimicrobial means with a target site to which said first component may be applied, and to permit sustained release of said antimicrobial agent to said target site, and in a second distinct and separate component, an amount of a dentally acceptable, ethanol insoluble biodegradable polymeric sealant means in an orally acceptable liquid vehicle means, which is effective to seal the antimicrobial means and binder means ingredients of said first component in position over the target site.
Claim 10
Dependent Claim
161 words
A two component liquid dental varnish composition containing kit the ingredients of which are collectively capable of combatting growth of caries-causing bacteria indigenous to the oral cavity by painting onto an application site therein, the kit comprising: a first component comprising in admixture an effective amount of at least one dentally acceptable antimicrobial means effective against Streptococcus mutans, an amount of benzoin which is effective in admixture with the antimicrobial means and an effective amount of an orally acceptable liquid vehicle means to form a film over the application site and to permit effective communication and sustained release of said antimicrobial means to the area onto which it is applied and, a second distinct and separate component compatible with said first component, comprising a sealing composition comprising a biodegradable polyurethane which in an amount sufficient, in admixture with an orally acceptable liquid vehicle means, when applied over the first component, to seal the first component in position over the target site.
Claim 11
Dependent Claim
161 words
A two component liquid dental varnish composition containing kit the ingredients of which are collectively capable of combatting growth of caries-causing bacteria indigenous to the oral cavity by painting onto an application site therein, the kit comprising: a first component comprising in admixture an effective amount of at least one dentally acceptable antimicrobial means effective against Streptococcus mutans, an amount of benzoin which is effective in admixture with the antimicrobial means and an effective amount of an orally acceptable liquid vehicle means to form a film over the application site and to permit effective communication and sustained release of said antimicrobial means to the area onto which it is applied and, a second distinct and separate component compatible with said first component, comprising a sealing composition comprising a biodegradable polyurethane which in an amount sufficient, in admixture with an orally acceptable liquid vehicle means, when applied over the first component, to seal the first component in position over the target site.
Claim 12
Dependent Claim
27 words
The two component kit of claim 7 wherein the dentally acceptable antimicrobial means effective against Streptococcus mutans is selected from erythromycin, chlorhexidine, salts thereof and mixtures thereof.
Claim 13
Dependent Claim
40 words
The two component kit of claim 8 wherein said second component is a polyurethane varnish comprising an orally acceptable film-forming biodegradable polyurethane in a solvent selected from methylene chloride, ethanol, tri- and tetra-halogenated methanes, fully halogenated ethanes, and mixtures thereof.
Claim 14
Dependent Claim
24 words
The two component kit of claim 9 wherein said second component is an orally acceptable film forming biodegradable polyurethane in solution in methylene chloride.
Claim 15
Dependent Claim
20 words
The two component kit of claim 10 wherein the orally acceptable liquid vehicle means in the first component is ethanol.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-11-27 | 1993-05-29 | 1993-11-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-11-27 | 1997-05-29 | 1997-11-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-11-27 | 2001-05-29 | 2001-11-28 | $7700.00 | Window Closed / Lapsed |