US4470964A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composition and method for reducing elution of therapeutic agents from teeth
Assignee: 3M Co
•
Filing: 1982-09-27
•
Granted: 1984-09-11
•
Expires: 2002-09-27
Abstract
Abstract A dentifrice composition containing a water-dispersible, membrane-forming material which, when applied to tooth surfaces in an oral environment, attaches thereto and forms a substantially continuous, hydrophobic barrier thereon which substantially reduces, elution of a previously applied therapeutic agent.
Inventors
- 👤 Robert W. H. Chang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 22:30
CPC Classifications
A; A61; A61Q; A61Q11/00; A61K; A61K8/00; A61K8/18; A61K8/19; A61K8/29; A61K8/30; A61K8/40; A61K8/44; A61K8/55; A61K8/58; A61K8/69; A61K8/70
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
221 words
A dentifrice composition for substantially effectively coating previously fluoride-treated teeth and thereby reducing elution of said fluoride from said teeth, said composition comprising a fluoride-containing caries prophylactic agent that is substantially free from polyvalent metal atoms; and at least 0.05% by weight of a cationic, water-dispersible, membrane-forming material which, when applied to the surface of said previously fluoride-treated teeth in an oral environment, forms a substantially continuous hydrophobic barrier thereon which substantially reduces the elution of said previously applied fluoride from said teeth, said cationic membrane-forming material being a nonpolymeric, fluorinated material having a formula selected from the group consisting of R 1 D and R 1 QD wherein R 1 is a non-ionic aliphatic radical optionally containing fluorine; Q is a divalent linking group which joins R 1 and D selected from the group consisting of oxygen, sulfur, --SO 2 --, and hydrocarbon groups containing from 1 to 30 carbon atoms, wherein said hydrocarbon groups may be straight chain or branched chain and may include unsaturation and aromatic groups, and wherein said hydrocarbon groups may contain hetero atoms in the skeletal chain selected from the group consisting of oxygen, nitrogen and sulfur; and D is a cationic terminal group selected from --NHC.sub.2 H.sub.4 NHC.sub.2 H.sub.4 NH.sub.2 --NH.sub.2 --NHC.sub.2 H.sub.4 NH.sub.2 ##STR17## --N.sup.+ (CH.sub.3).sub.2 C.sub.2 H.sub.4 OH.H.sub.2 PO.sub.4.sup.- -N.sup.+ (CH.sub.3).sub.3 Cl.sup.-.
Claim 2
Dependent Claim
221 words
A dentifrice composition for substantially effectively coating previously fluoride-treated teeth and thereby reducing elution of said fluoride from said teeth, said composition comprising a fluoride-containing caries prophylactic agent that is substantially free from polyvalent metal atoms; and at least 0.05% by weight of a cationic, water-dispersible, membrane-forming material which, when applied to the surface of said previously fluoride-treated teeth in an oral environment, forms a substantially continuous hydrophobic barrier thereon which substantially reduces the elution of said previously applied fluoride from said teeth, said cationic membrane-forming material being a nonpolymeric, fluorinated material having a formula selected from the group consisting of R 1 D and R 1 QD wherein R 1 is a non-ionic aliphatic radical optionally containing fluorine; Q is a divalent linking group which joins R 1 and D selected from the group consisting of oxygen, sulfur, --SO 2 --, and hydrocarbon groups containing from 1 to 30 carbon atoms, wherein said hydrocarbon groups may be straight chain or branched chain and may include unsaturation and aromatic groups, and wherein said hydrocarbon groups may contain hetero atoms in the skeletal chain selected from the group consisting of oxygen, nitrogen and sulfur; and D is a cationic terminal group selected from --NHC.sub.2 H.sub.4 NHC.sub.2 H.sub.4 NH.sub.2 --NH.sub.2 --NHC.sub.2 H.sub.4 NH.sub.2 ##STR17## --N.sup.+ (CH.sub.3).sub.2 C.sub.2 H.sub.4 OH.H.sub.2 PO.sub.4.sup.- -N.sup.+ (CH.sub.3).sub.3 Cl.sup.-.
Claim 3
Dependent Claim
110 words
A dentifrice composition according to claim 1 wherein said membrane-forming material is selected from materials of the formulae R.sub.f SO.sub.2 N(R.sup.2)R.sup.3 NHA R.sub.f SO.sub.2 N(R.sup.2)R.sup.3 N.sup.+ R.sub.3.sup.7 E.sup.- where R f is a monovalent, stable, inert, fluorinated, saturated, non-polar aliphatic radical containing from about 4 to 16 carbon atoms; R 2 is selected from hydrogen and alkyl groups having from 1 to 6 carbon atoms; R 3 is selected from alkylene, arylene, alkarylene and aralkylene groups containing from 1 to 12 carbon atoms; R 7 is an alkyl group containing from 1 to 6 carbon atoms; and A is a proton or a poly(alkylamino) group, and E is an anion.
Claim 4
Dependent Claim
16 words
A dentifrice composition according to claim 2 wherein said membrane-forming material is R.sub.f SO.sub.2 N(R.sup.2)R.sup.3 NHA.
Claim 5
Dependent Claim
41 words
A dentifrice composition according to claim 3 wherein said membrane-forming material is selected from C.sub.8 F.sub.17 SO.sub.2 N(C.sub.2 H.sub.5)C.sub.2 H.sub.4 NHC.sub.2 H.sub.4 NC.sub.2 H.sub.4 NH.sub.2 C.sub.8 F.sub.17 SO.sub.2 NHC.sub.2 H.sub.4 NH.sub.2 ##STR18## C.sub.8 F.sub.17 SO.sub.2 H(C.sub.2 H.sub.5)C.sub.2 H.sub.4 NC.sub.2 H.sub.4 NH.sub.2.
Claim 6
Dependent Claim
26 words
A dentifrice composition according to claim 2 wherein said membrane-forming material has the formula P f SO 2 N(R 2 )R 3+ NR 3 7 E.
Claim 7
Dependent Claim
43 words
A dentifrice composition according to claim 5 wherein said membrane-forming material is selected from the group [C.sub.8 F.sub.17 SO.sub.2 N(CH.sub.3)C.sub.2 H.sub.4 N.sup.⊕ (CH.sub.3).sub.3 ]Cl.sup.⊕ [C.sub.8 F.sub.17 SO.sub.2 NHC.sub.3 H.sub.6 N.sup.⊕ (CH.sub.3).sub.3 ]Cl.sup.⊕ [C.sub.8 F.sub.17 SO.sub.2 NHC.sub.3 H.sub.6 N.sup.⊕ (CH.sub.3).sub.2 C.sub.2 H.sub.4 OH]H.sub.2 PO.sub.4.sup.⊕.
Claim 8
Independent Claim
250 words
A method of substantially reducing elution of a therapeutic agent previously applied to teeth which comprises the steps of applying said therapeutic agent to teeth, and applying a dentifrice composition to said treated teeth, wherein said dentifrice composition comprises (1) at least one ingredient selected from the group consisting of therapeutic agents, polishing agents, surfactants, flavoring agents, sweetening agents, thickening agents and humectants that are substantially free from polyvalent metal atoms, and (2) at least 0.05% by weight of a cationic, non-polymeric, fluorinated, water-dispersible, membrane-forming material which, when applied to the surface of the teeth in an oral environment, forms a substantially continuous hydrophobic barrier thereon which substantially reduces the elution of said previously applied therapeutic agent from said teeth, and which has a formula selected from the group consisting of R 1 D and R 1 D wherein R 1 is a non-ionic aliphatic radical optionally containing fluorine; Q is divalent linking group which joins R 1 and D selected from the group consisting of oxygen, sulfur, --SO 2 --, and hydrocarbon groups containing from 1 to 30 carbon atoms, wherein said hydrocarbon groups may be straight chain or branched chain and may include unsaturation and aromatic groups, and wherein said hydrocarbon groups may contain hetero atoms in the skeletal chain selected from the group consisting of oxygen, nitrogen and sulfur; and D is a cationic terminal group selected from --NCH.sub.2 H.sub.4 NHC.sub.2 H.sub.4 NH.sub.2 --NH.sub.2 --NHC.sub.2 H.sub.4 NH.sub.2 ##STR19## --N.sup.+ (CH.sub.3).sub.2 C.sub.2 H.sub.4 OH.H.sub.2 PO.sub.4.sup.- --N.sup.+ (CH.sub.3).sub.3 Cl.sup.-
Claim 9
Independent Claim
250 words
A method of substantially reducing elution of a therapeutic agent previously applied to teeth which comprises the steps of applying said therapeutic agent to teeth, and applying a dentifrice composition to said treated teeth, wherein said dentifrice composition comprises (1) at least one ingredient selected from the group consisting of therapeutic agents, polishing agents, surfactants, flavoring agents, sweetening agents, thickening agents and humectants that are substantially free from polyvalent metal atoms, and (2) at least 0.05% by weight of a cationic, non-polymeric, fluorinated, water-dispersible, membrane-forming material which, when applied to the surface of the teeth in an oral environment, forms a substantially continuous hydrophobic barrier thereon which substantially reduces the elution of said previously applied therapeutic agent from said teeth, and which has a formula selected from the group consisting of R 1 D and R 1 D wherein R 1 is a non-ionic aliphatic radical optionally containing fluorine; Q is divalent linking group which joins R 1 and D selected from the group consisting of oxygen, sulfur, --SO 2 --, and hydrocarbon groups containing from 1 to 30 carbon atoms, wherein said hydrocarbon groups may be straight chain or branched chain and may include unsaturation and aromatic groups, and wherein said hydrocarbon groups may contain hetero atoms in the skeletal chain selected from the group consisting of oxygen, nitrogen and sulfur; and D is a cationic terminal group selected from --NCH.sub.2 H.sub.4 NHC.sub.2 H.sub.4 NH.sub.2 --NH.sub.2 --NHC.sub.2 H.sub.4 NH.sub.2 ##STR19## --N.sup.+ (CH.sub.3).sub.2 C.sub.2 H.sub.4 OH.H.sub.2 PO.sub.4.sup.- --N.sup.+ (CH.sub.3).sub.3 Cl.sup.-
References Cited (Backward Citations)
US2580473A
Cited
US2829086A
Cited
US2809990A
Cited
US2955985A
Cited
US3029191A
Cited
US3120469A
Cited
US3429963A
Cited
US3431208A
Cited
US3507955A
Cited
US3624120A
Cited
DE2164383A1
Cited
US3969499A
Cited
US3751568A
Cited
US3956480A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-11 | 1988-03-12 | 1988-09-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-11 | 1992-03-12 | 1992-09-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-11 | 1996-03-12 | 1996-09-11 | $7700.00 | Window Closed / Lapsed |