Patent US4877501A successfully refreshed from Google Patents.
US4877501A
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Process for fabrication of lipid microstructures
Assignee: Science Applications International Corp SAIC
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Filing: 1987-02-06
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Granted: 1989-10-31
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Expires: 2007-02-06
Abstract
Abstract Method and process for forming selected microstructures having predetermined shape and dimension from surfactants comprising the steps of: selecting a lipid which self aggregates into a predetermined microstructure selected from the group of helices and tubules; selecting a lipid solvating organic solvent; dissolving the selected lipid in the selected organic solvent; adding a predetermined amount of non-solvent to the selected organic solvent; and allowing the solution to sit for a predetermined period of time at a predetermined temperature.
Inventors
- 👤 Joel M. Schnur
- 👤 Ronald Price
- 👤 Paul Yager
- 👤 Paul Schoen
- 👤 Jacque H. Georger
- 👤 Alok Singh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 16:31
CPC Classifications
G; G03; G03F; G03F7/00; G03F7/004; G03F7/025; B; B82; B82Y; B82Y10/00; C; C11; C11B; C11B3/00; C30; C30B; C30B29/00; C30B29/54; C30B29/58; C30B7/00; G03F7/0045; H; H10; H10K; H10K85/00; H10K85/761
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
102 words
Process for forming microstructures of selected shape and dimension from surfactants comprising the steps of: selecting a lipid which self aggregates into a microstructure selected from the group consisting of helices and tubules; selecting a lipid solvating organic solvent in which microstructures form; dissolving the selected lipid in the selected organic solvent; adding a non-solvent to the selected organic solvent in an amount sufficient to initiate microstructure growth; allowing the selected lipid to grow into the microstructure in the solution of organic solvent and non-solvent for a period of time and at a temperature below the melting point of the selected lipid.
Claim 2
Dependent Claim
102 words
Process for forming microstructures of selected shape and dimension from surfactants comprising the steps of: selecting a lipid which self aggregates into a microstructure selected from the group consisting of helices and tubules; selecting a lipid solvating organic solvent in which microstructures form; dissolving the selected lipid in the selected organic solvent; adding a non-solvent to the selected organic solvent in an amount sufficient to initiate microstructure growth; allowing the selected lipid to grow into the microstructure in the solution of organic solvent and non-solvent for a period of time and at a temperature below the melting point of the selected lipid.
Claim 3
Dependent Claim
35 words
The process of claim 1 wherein the step of allowing further comprises maintaining the temperature of the solution at between 10 and about 30 degrees Centigrade below the melting point of the lipid in water.
Claim 4
Dependent Claim
16 words
The process of claim 2 wherein said period of time is less than about 24 hours.
Claim 5
Dependent Claim
23 words
The process of claim 2 wherein the organic solvent is selected from the group consisting of alcohols, polyols, tetrahydrofuran, chloroform, and mixtures thereof.
Claim 6
Dependent Claim
35 words
The process of claim 2 wherein the step of adding further comprises adding enough non-solvent to the selected organic solvent to achieve a volume ratio of organic solvent to non-solvent of greater than about 1:10.
Claim 7
Dependent Claim
16 words
The process of claim 1 wherein said period of time is less than about 24 hours.
Claim 8
Dependent Claim
23 words
The process of claim 1 wherein the organic solvent is selected from the group consisting of alcohols, polyols, tetrahydrofuran, chloroform, and mixtures thereof.
Claim 9
Dependent Claim
35 words
The process of claim 7 wherein the step of adding further comprises adding enough non-solvent to the selected organic solvent to achieve a volume ratio of organic solvent to water of greater than about 1:10.
Claim 10
Dependent Claim
29 words
The process of claim 8 wherein the step of selecting the lipid further comprises preselecting a certain amount of the lipid to be dissolved in the selected organic solvent.
Claim 11
Dependent Claim
23 words
The process of claim 9 further comprising exposing the lipid solution for a period of time to radiation which will polymerize the lipid.
Claim 12
Dependent Claim
62 words
The process of claim 9 wherein the selected lipid has the formula: ##STR3## wherein R 1 and R 2 are selected from the group consisting of saturated and unsaturated hydrocarbon chains having fewer than thirty two carbon atoms, X and Y are selected from the group consisting of alkyl, olefin, and alpha, beta unsaturated carboxy compounds, and Z is a phosphoryl moiety.
Claim 13
Dependent Claim
21 words
The process of claim 11 wherein one of both of R 1 and R 2 include a diacetylenic moiety in conjugation.
Claim 14
Dependent Claim
19 words
The process of claim 12 wherein the non-solvent is selected from the group consisting of water and hydrocarbon non-solvents.
Claim 15
Dependent Claim
29 words
The process of claim 1 wherein the step of selecting the lipid further comprises preselecting a certain amount of the lipid to be dissolved in the selected organic solvent.
Claim 16
Dependent Claim
23 words
The process of claim 1 further comprising exposing the lipid solution for a period of time to radiation which will polymerize the lipid.
Claim 17
Dependent Claim
62 words
The process of claim 1 wherein the selected lipid has the formula: ##STR4## wherein R 1 and R 2 are selected from the group consisting of saturated and unsaturated hydrocarbon chains having fewer than thirty two carbon atoms, X and Y are selected from the group consisting of alkyl, olefin, and alpha, beta unsaturated carboxy compounds, and Z is a phosphoryl moiety.
Claim 18
Dependent Claim
21 words
The process of claim 16 wherein one or both of R 1 and R 2 include a diacetylenic moiety in conjugation.
Claim 19
Dependent Claim
19 words
The process of claim 17 wherein the non-solvent is selected from the group consisting of water and hydrocarbon non-solvents.
Claim 20
Dependent Claim
53 words
The process of claim 16 wherein the lipid as the formula: ##STR5## where m and p are selected from the group consisting of 5, 6, 7, 8, 9, 10, and 11 and n and r are selected from the group consisting of 7, 8, 9, 10, 11, 12, 13, 14, 15 and 16.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1992-10-30 | 1993-05-01 | 1993-10-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-30 | 1997-05-01 | 1997-10-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-30 | 2001-05-01 | 2001-10-31 | $7700.00 | Window Closed / Lapsed |