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US4634599A
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Method for making ordered monolayers of macromolecules
Assignee: General Electric Co
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Filing: 1985-05-02
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Granted: 1987-01-06
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Expires: 2005-05-02
Abstract
Abstract A method is provided for making ordered monolayers of macromolecules. A supported lipid polylayer is contacted with macromolecules in an aqueous polar solution and allowed to incubate.
Inventors
- 👤 Egidijus E. Uzgiris
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:54
CPC Classifications
C; C30; C30B; C30B7/00; C30B7/14; C30B29/00; C30B29/54; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54313; G01N33/5432; G01N33/58; G01N33/585; G01N33/586; Y; Y10; Y10T; Y10T428/00; Y10T428/30; Y10T428/31504; Y10T428/31536; Y10T428/31725; Y10T428/31768
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
88 words
A method for effecting the nucleation of macromolecules as an ordered monolayer on a hydrophilic region of a supported lipid polylayer having at least two hydrophilic regions and at least one interior lipophilic region comprising, (1) effecting contact between the macromolecules and a hydrophilic region of the lipid polylayer in an aqueous medium and (2) incubating the resulting mixture for a time sufficient to allow for the ordering of such macromolecules, where the lipid polylayer is anchored onto a supporting hydrophilic substrate through one of its hydrophilic regions.
Claim 2
Independent Claim
88 words
A method for effecting the nucleation of macromolecules as an ordered monolayer on a hydrophilic region of a supported lipid polylayer having at least two hydrophilic regions and at least one interior lipophilic region comprising, (1) effecting contact between the macromolecules and a hydrophilic region of the lipid polylayer in an aqueous medium and (2) incubating the resulting mixture for a time sufficient to allow for the ordering of such macromolecules, where the lipid polylayer is anchored onto a supporting hydrophilic substrate through one of its hydrophilic regions.
Claim 3
Dependent Claim
15 words
A method in accordance with claim 1, where the lipid polylayer is a lipid bilayer.
Claim 4
Dependent Claim
16 words
A method in accordance with claim 1, where the lipid polylayer is formed from N-dinitrophenyl phosphatidylethanolamine.
Claim 5
Dependent Claim
15 words
A method in accordance with claim 1, where the lipid polylayer is formed from N-dinitrophenylaminocaproylphosphatidylethanolamine.
Claim 6
Dependent Claim
13 words
A method in accordance with claim 1, where the macromolecules are polyamino acids.
Claim 7
Dependent Claim
13 words
A method in accordance with claim 1, where the macromolecule is an antibody.
References Cited (Backward Citations)
US4172827A
Cited
US4489133A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-01-05 | 1990-07-07 | 1991-01-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-01-05 | 1994-07-07 | 1995-01-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-01-05 | 1998-07-07 | 1999-01-06 | $7700.00 | Window Closed / Lapsed |