Method of treating tinea pedis and related dermatophytic infections

Claim 1

A therapeutic method of treating the chronic human superficial fungus infection tinea pedis produced by the pathogenic dermatophytic fungi Microsporum sp., Trichophyton sp., and Epidermophyton sp., which invade and attack keratinized skin areas of the body comprising repeatedly applying topically to itching, macerated, cracked, and scaling skin areas of the body at the site of the infection, a fungicidally effective amount of a carrier antagonistic to the dermatophytic fungi, in order to exert at least an inhibitory growth effect upon the dermatophytes, the carrier including an antimicrobial organosilane having the general formula selected from the group consisting of ##STR4## wherein, in each formula, R is an alkyl radical of 1 to 4 carbon atoms or hydrogen; a has a value of 0, 1 or 2; R' is a methyl or ethyl radical; R" is an alkylene group of 1 to 4 carbon atoms; R'", R"" and R v are each independently selected from a group consisting of alkyl radicals of 1 to 18 carbon atoms, --CH 2 C 6 H 5 , --CH 2 CH 2 OH, --CH 2 OH, and --(CH 2 ) x NHC(O)R vi , wherein x has a value of from 2 to 10 and R vi is a perfluoroalkyl radical having from 1 to 12 carbon atoms; and X is chloride, bromide, fluoride, iodide, acetate or tosylate.