US4259103A
Expired / Lapsed
US
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Method of reducing the number of microorganisms in a media and a method of preservation
Assignee: Dow Silicones Corp
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Filing: 1979-05-14
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Granted: 1981-03-31
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Expires: 1999-05-14
Abstract
Abstract What is disclosed is a method of reducing microorganisms by contacting the microorganisms with the surface of a substrate which has been altered by contacting a substrate which develops a negative charge in water with a substance that ionizes in water to form cations and anions, which cations absorb to the substrate by a process of ion exchange in which protons are replaced by the cations of the ionizing substance. The altered surfaces can include hospital sheeting, clothing and a wide variety of surfaces which come into contact with microorganisms.
Inventors
- 👤 James R. Malek
- 👤 John L. Speier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 05:06
CPC Classifications
A; A01; A01N; A01N31/00; A01N31/02; A01N31/04; A01N47/00; A01N47/40; A01N47/42; A01N55/00; A01N57/00; A01N57/34; A23; A23B; A23B11/00; A23B11/10; A23B11/18; A23B2/00; A23B2/70; A23B2/725; A23B2/729
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
330 words
A method of reducing the number of viable bacteria, fungi, algae and yeast in media by physically contacting the bacteria, fungi, algae and yeast with a surface which has been altered in a manner which comprises contacting a substrate, which develops a negative charge in water, with an amount effective to inhibit the growth of said microorganisms of a substance that ionizes in water to form cations and anions which substance is selected from the group consisting of sulfonium salts of the formula R 8 R 9 R 10 S + X - , sulfonium salts of the formula ##STR6## isothiuronium salts of the formula RSC(NH 2 ) 2 + X - , isothiuronium salts of the formula ##STR7## phosphonium salts of the formula R 4 R 5 R 6 R 7 P + X - , and phosphonium salts of the formula ##STR8## wherein R 8 , R 9 and R 10 are independently alkyl groups or aralkyl groups wherein there is a total of less than 30 carbon atoms in the molecule or a silylsubstituted alkyl radical of the formula ##STR9## where Y is a hydrolyzable group, Q is an alkyl radical of 1 or 2 carbon atoms or (CH 3 ) 3 SiO, a has an average value of 0-3, b has an average value of 0-3, n is an integer of 1 or greater and X - is a water soluble monovalent anion, R is independently alkyl or aralkyl groups wherein there is a total of less than 20 carbon atoms in the molecule or a silylsubstituted alkyl radical of the formula ##STR10## as defined above, R 4 , R 5 , R 6 and R 7 are as defined above for R 8 , R 9 and R 10 ; R 11 and R 12 are independently alkyl groups or aralkyl groups wherein there is a total of less than 60 carbon atoms in the molecule and d is an integer of 1 or greater.
Claim 2
Independent Claim
330 words
A method of reducing the number of viable bacteria, fungi, algae and yeast in media by physically contacting the bacteria, fungi, algae and yeast with a surface which has been altered in a manner which comprises contacting a substrate, which develops a negative charge in water, with an amount effective to inhibit the growth of said microorganisms of a substance that ionizes in water to form cations and anions which substance is selected from the group consisting of sulfonium salts of the formula R 8 R 9 R 10 S + X - , sulfonium salts of the formula ##STR6## isothiuronium salts of the formula RSC(NH 2 ) 2 + X - , isothiuronium salts of the formula ##STR7## phosphonium salts of the formula R 4 R 5 R 6 R 7 P + X - , and phosphonium salts of the formula ##STR8## wherein R 8 , R 9 and R 10 are independently alkyl groups or aralkyl groups wherein there is a total of less than 30 carbon atoms in the molecule or a silylsubstituted alkyl radical of the formula ##STR9## where Y is a hydrolyzable group, Q is an alkyl radical of 1 or 2 carbon atoms or (CH 3 ) 3 SiO, a has an average value of 0-3, b has an average value of 0-3, n is an integer of 1 or greater and X - is a water soluble monovalent anion, R is independently alkyl or aralkyl groups wherein there is a total of less than 20 carbon atoms in the molecule or a silylsubstituted alkyl radical of the formula ##STR10## as defined above, R 4 , R 5 , R 6 and R 7 are as defined above for R 8 , R 9 and R 10 ; R 11 and R 12 are independently alkyl groups or aralkyl groups wherein there is a total of less than 60 carbon atoms in the molecule and d is an integer of 1 or greater.
Claim 3
Dependent Claim
14 words
The method of claim 1 in which the microorganisms are gram-positive or gram-negative bacteria.
Claim 4
Dependent Claim
11 words
The method of claim 1 in which the microorganisms are fungi.
Claim 5
Dependent Claim
11 words
The method of claim 1 in which the microorganisms are yeasts.
Claim 6
Dependent Claim
15 words
A method as claimed in claim 1 wherein the sulfonium salt is a sulfonium halide.
Claim 7
Dependent Claim
12 words
A method as claimed in claim 5 wherein the halide is chloride.
Claim 8
Dependent Claim
12 words
A method as claimed in claim 5 wherein the halide is iodide.
Claim 9
Dependent Claim
12 words
A method as claimed in claim 5 wherein the halide is bromide.
Claim 10
Dependent Claim
31 words
A method as claimed in claim 1 wherein in the groups R 8 , R 9 and R 10 , at least one such group has at least 10 carbon atoms.
Claim 11
Dependent Claim
31 words
A method as claimed in claim 5 wherein the sulfonium salt is (CH 3 O) 3 Si(CH 2 ) 3 S + (CH 3 )C 18 H 37 I - .
Claim 12
Dependent Claim
31 words
A method as claimed in claim 5 wherein the sulfonium salt is (CH 3 O) 3 Si(CH 2 ) 3 S + (CH 3 )C 2 H 5 I - .
Claim 13
Dependent Claim
15 words
A method as claimed in claim 1 wherein the isothiuronium salt is an isothiuronium halide.
Claim 14
Dependent Claim
15 words
A method as claimed in claim 12 wherein the isothiuronium salt is an isothiuronium chloride.
Claim 15
Dependent Claim
15 words
A method as claimed in claim 12 wherein the isothiuronium salt is an isothiuronium iodide.
Claim 16
Dependent Claim
15 words
A method as claimed in claim 12 wherein the isothiuronium salt is an isothiuronium bromide.
Claim 17
Dependent Claim
29 words
A method as claimed in claim 12 wherein the isothiuronium salt is (CH 3 O) 3 Si(CH 2 ) 3 S + C(NH 2 ) 2 Cl - .
Claim 18
Dependent Claim
15 words
A method as claimed in claim 1 wherein the phosphonium salt is a phosphonium halide.
Claim 19
Dependent Claim
15 words
A method as claimed in claim 17 wherein the phosphonium salt is a phosphonium chloride.
Claim 20
Dependent Claim
14 words
A method as claimed in claim 17 wherein the phosphonium salt is phosphonium iodide.
Claim 21
Dependent Claim
15 words
A method as claimed in claim 17 wherein the phosphonium salt is a phosphonium bromide.
Claim 22
Dependent Claim
31 words
A method as claimed in claim 17 wherein the phosphonium salt is (CH 3 O) 3 Si(CH 2 ) 3 P + (n-C 4 H 9 ) 3 I - .
Claim 23
Dependent Claim
31 words
A method as claimed in claim 21 wherein the phosphonium salt is (CH 3 O) 3 Si(CH 2 ) 3 P + (C 6 H 5 ) 3 I - .
Claim 24
Dependent Claim
15 words
A method as claimed in claim 1 wherein the sulfonium salt is a sulfonium carboxylate.
Claim 25
Dependent Claim
15 words
A method as claimed in claim 1 wherein the isothiuronium salt is an isothiuronium carboxylate.
Claim 26
Dependent Claim
15 words
A method as claimed in claim 1 wherein the phosphonium salt is a phosphonium carboxylate.
Claim 27
Independent Claim
93 words
A method of reducing the number of viable bacterial, fungi, algae and yeast in media by physically contacting the bacteria, fungi, algae and yeast with a surface which has been altered in a manner which comprises contacting a substrate, which develops a negative charge in water, with an amount effective to inhibit the growth of said microorganism of a substance that ionizes in water to form cations and anions which substance consists of an organic amine of the formula ##STR11## in which d in each case is an integer of 1 or greater.
Claim 28
Independent Claim
93 words
A method of reducing the number of viable bacterial, fungi, algae and yeast in media by physically contacting the bacteria, fungi, algae and yeast with a surface which has been altered in a manner which comprises contacting a substrate, which develops a negative charge in water, with an amount effective to inhibit the growth of said microorganism of a substance that ionizes in water to form cations and anions which substance consists of an organic amine of the formula ##STR11## in which d in each case is an integer of 1 or greater.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-03-30 | 1984-09-29 | 1985-03-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-03-30 | 1988-09-29 | 1989-03-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-03-30 | 1992-09-29 | 1993-03-31 | $7700.00 | Window Closed / Lapsed |