US4861598A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Controlled release bases for pharmaceuticals
Assignee: Purdue Pharma LP
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Filing: 1986-07-18
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Granted: 1989-08-29
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Expires: 2006-07-18
Abstract
Abstract The release of therapeutically active agents from controlled release bases is extended by using a combination of a higher aliphatic alcohol and an acrylic resin as the base material.
Inventors
- 👤 Benjamin Oshlack
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 23:26
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2013; A61K47/00; A61K9/2022; A61K9/2027; A61P; A61P11/00; A61P11/08; A61P11/14; A61P25/00; A61P25/04; A61P25/18; A61P25/24; A61P25/26; A61P43/00; A61P9/00; A61P9/06
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
90 words
Extended action controlled release pharmaceutical composition for oral administration, comprising a pharmaceutically effective amount of a pharmaceutically active agent distributed in a controlled release core or matrix comprising a higher aliphatic alcohol of 10-18 carbon atoms and a pharmaceutically acceptable acrylic resin, said acrylic resin being in an amount of about 10-60% by weight of the weight of said higher aliphatic alcohol plus said acrylic resin wherein said pharmaceutical agent is amitryptaline, atropine, chlorpheniramine, chlorpromizine, codeine, dexbrompheniramine, diphenylhydramine, doxilamine, ephedrine, hyoscyamine, morphine, oxycodone, papavarine, phenylpropanolamine, propranolol, quinidine, scoplamine or thioridazine.
Claim 2
Dependent Claim
90 words
Extended action controlled release pharmaceutical composition for oral administration, comprising a pharmaceutically effective amount of a pharmaceutically active agent distributed in a controlled release core or matrix comprising a higher aliphatic alcohol of 10-18 carbon atoms and a pharmaceutically acceptable acrylic resin, said acrylic resin being in an amount of about 10-60% by weight of the weight of said higher aliphatic alcohol plus said acrylic resin wherein said pharmaceutical agent is amitryptaline, atropine, chlorpheniramine, chlorpromizine, codeine, dexbrompheniramine, diphenylhydramine, doxilamine, ephedrine, hyoscyamine, morphine, oxycodone, papavarine, phenylpropanolamine, propranolol, quinidine, scoplamine or thioridazine.
Claim 3
Dependent Claim
18 words
Pharmaceutical composition according to claim 1 wherein said acrylic resin is an amount of about 15-40% by weight.
Claim 4
Dependent Claim
18 words
Pharmaceutical composition according to claim 1 wherein said acrylic resin is in amount of about 20-35% by weight.
Claim 5
Dependent Claim
23 words
Pharmaceutical composition according to claim 1 wherein said core or matrix also includes a binder in an amount sufficient to bind said composition.
Claim 6
Dependent Claim
15 words
Pharmaceutical composition according to claim 4 wherein said core or matrix also includes a filler.
Claim 7
Dependent Claim
20 words
Pharmaceutical composition according to claim 5 wherein said core or matrix also includes a disintegrant in a disintegrant effective amount.
Claim 8
Dependent Claim
15 words
Pharmaceutical composition according to claim 6 wherein said core or matrix also includes a lubricant.
Claim 9
Dependent Claim
19 words
Pharmaceutical composition according to claim 1 wherein said core or matrix constitutes about 20-40% by weight of said composition.
Claim 10
Dependent Claim
15 words
Pharmaceutical composition according to claim 1 wherein said pharmaceutically active agent is highly water soluble.
Claim 11
Dependent Claim
12 words
Pharmaceutical composition according to claim 1 wherein said pharmaceutical agent is oxycodone.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-08-28 | 1993-02-27 | 1993-08-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-08-28 | 1997-02-27 | 1997-08-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-08-28 | 2001-02-27 | 2001-08-29 | $7700.00 | Window Closed / Lapsed |