Extended action controlled release compositions

Claim 1

On an extended action controlled release pharmaceutical composition for oral administration comprising a hydrated hydroxyalkylcellulose and hydrophobic 10 to 18 carbon atoms higher aliphatic alcohol or paraffin wax balanced matrix melt granulation pharmaceutically acceptable controlled release core or matrix for the oral administration of pharmaceutically active agents, said controlled release core or matrix providing upon oral ingestion thereof slow release in the body of pharmaceutically active agents distributed therein, the improvement wherein said composition comprises said controlled release core or matrix for oral administration having distributed therethrough a pharmaceutically effective amount of a pharmacologically active substance in salt form thereof and in the free base form thereof, said pharmaceutically effective amount comprising between about 75% and 25% by weight of a pharmaceutically acceptable salt form of said pharmacologically active substance and between about 25% and 75% by weight of the free base form of said pharmacologically active substance, the amounts being based on the pharmacologically active moiety of said pharmacologically active substance.