Patent US2503865A successfully refreshed from Google Patents.
US4179497A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Solid state ophthalmic medication
Assignee: Merck and Co Inc
•
Filing: 1978-11-13
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Granted: 1979-12-18
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Expires: 1998-11-13
Abstract
Abstract Solid unit dosage medicaments which are suitable for use in animals and humans are prepared with hydroxypropyl cellulose as the primary formulating excipient. These medicaments are particularly suitable for ophthalmic use since they are slowly but completely water soluble when they are inserted in the cul-de-sac of the eye and thus provide for a convenient means of prolonged treatment of the eye with concomitant reduced dosing frequency.
Inventors
- 👤 Edward M. Cohen
- 👤 Wayne M. Grim
- 👤 Richard J. Harwood
- 👤 Gunvant N. Mehta
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 19:21
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0048; A61K9/0051
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
65 words
The method of applying pilocarpine to the eye which comprises inserting a solid ophthalmic insert comprising between 0.1 to about 35% of pilocarpine pamoate as an ophthalmic active agent admixed in a matrix of from about 65 to about 99% of hydroxypropyl cellulose in the cul-de-sac of the conjunctiva to thereby dispense the active agent pilocarpine to the eye over a prolonged period of time.
Claim 2
Independent Claim
65 words
The method of applying pilocarpine to the eye which comprises inserting a solid ophthalmic insert comprising between 0.1 to about 35% of pilocarpine pamoate as an ophthalmic active agent admixed in a matrix of from about 65 to about 99% of hydroxypropyl cellulose in the cul-de-sac of the conjunctiva to thereby dispense the active agent pilocarpine to the eye over a prolonged period of time.
References Cited (Backward Citations)
US108034A
Cited
US273410A
Cited
US1872826A
Cited
US2397903A
Cited
US3278521A
Cited
US3424842A
Cited
US3450814A
Cited
GB1090492A
Cited
GB1324191A
Cited
US3852421A
Cited
GB1362700A
Cited
US3863633A
Cited
US3981303A
Cited
US3986510A
Cited
US3993071A
Cited
US3845201A
Cited
US3870791A
Cited
US3867519A
Cited
US3868445A
Cited
US3875300A
Cited
US3776001A
Cited
US4001388A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-12-17 | 1983-06-18 | 1983-12-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-12-17 | 1987-06-18 | 1987-12-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-12-17 | 1991-06-18 | 1991-12-18 | $7700.00 | Window Closed / Lapsed |