US4263273A
Expired / Lapsed
US
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Pharmaceutical preparation comprising a cardiac glycoside with a polymer coating
Assignee: AstraZeneca AB
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Filing: 1979-12-17
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Granted: 1981-04-21
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Expires: 1999-12-17
Abstract
Abstract A solid pharmaceutical preparation for administration in dosage unit form comprising a therapeutically effective cardiac glycoside, whereby each dosage unit is to comprise a plurality of bodies, each of said bodies having a pharmaceutically indifferent core, a first layer thereon containing the glycoside and a second layer containing a polymer insoluble in gastric juice and soluble in intestinal juice, a process for preparing such preparation and a method of treatment employing the same.
Inventors
- 👤 Curt H. Appelgren
- 👤 Conny B. Bogentoft
- 👤 John A. Sjogren
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 01:23
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/7028; A61K31/7034; A61K31/704; A61K9/00; A61K9/48; A61K9/50; A61K9/5073; A61K9/5078
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
105 words
A pharmaceutical preparation comprising a cardiac glycoside with a polymer coating, characterized in that said pharmaceutical preparation is in the form of a plurality of small bodies, each body comprising a fraction of a therapeutically effective dosage of the cardiac glycoside, whereby each body has a core made up of pharmaceutically indifferent material, and on said core a first layer made up of a composition comprising the cardiac glycoside, and thereon a second layer comprising an anionic carboxylic polymer being difficultly soluble or insoluble below a given pH value in the interval of pH 4-7.5 but being soluble at a pH above said given value.
Claim 2
Dependent Claim
105 words
A pharmaceutical preparation comprising a cardiac glycoside with a polymer coating, characterized in that said pharmaceutical preparation is in the form of a plurality of small bodies, each body comprising a fraction of a therapeutically effective dosage of the cardiac glycoside, whereby each body has a core made up of pharmaceutically indifferent material, and on said core a first layer made up of a composition comprising the cardiac glycoside, and thereon a second layer comprising an anionic carboxylic polymer being difficultly soluble or insoluble below a given pH value in the interval of pH 4-7.5 but being soluble at a pH above said given value.
Claim 3
Dependent Claim
32 words
A solid pharmaceutical preparation according to claim 1, characterized in that each of the first layer and the second layer is a layer applied by spraying a solution of the components thereof.
Claim 4
Dependent Claim
35 words
A pharmaceutical preparation in accordance with claim 1 or 2 characterized in that said first layer further comprises a water soluble polymer having the ability to increase the solubility or releasability of the cardiac glycoside.
Claim 5
Dependent Claim
117 words
A process for preparing a pharmaceutical preparation comprising a cardiac glycoside with a polymer coating, characterized in that said pharmaceutical preparation is given the form of a plurality of small bodies, each body comprising a fraction of a therapeutically effective dosage of the cardiac glycoside, by providing a large number of cores made up of pharmaceutically indifferent material, with a first layer made up of a composition comprising the cardiac glycoside, whereupon the bodies comprising said core and first layer are provided with a second layer comprising an anionic carboxylic polymer being difficultly soluble or insoluble below a given pH value in the interval of pH 4-7.5 but being soluble at a pH above said given value.
Claim 6
Dependent Claim
117 words
A process for preparing a pharmaceutical preparation comprising a cardiac glycoside with a polymer coating, characterized in that said pharmaceutical preparation is given the form of a plurality of small bodies, each body comprising a fraction of a therapeutically effective dosage of the cardiac glycoside, by providing a large number of cores made up of pharmaceutically indifferent material, with a first layer made up of a composition comprising the cardiac glycoside, whereupon the bodies comprising said core and first layer are provided with a second layer comprising an anionic carboxylic polymer being difficultly soluble or insoluble below a given pH value in the interval of pH 4-7.5 but being soluble at a pH above said given value.
Claim 7
Dependent Claim
29 words
A process according to claim 4, characterized in that each of the first and the second layer is applied by adding a solution of the components of the layer.
Claim 8
Dependent Claim
15 words
A process according to claim 5, characterized in that each solution is applied by spraying.
Claim 9
Dependent Claim
24 words
A process according to claim 5 or 6, characterized in that the first and the second layer are applied in a fluid bed apparatus.
Claim 10
Dependent Claim
24 words
A method of treatment of cardiac disorders comprising administrating to a mammal including man a therepeutically effective dose of the preparation of claim 1.
Claim 11
Dependent Claim
136 words
A pharmaceutical preparation comprising a cardiac glycoside with a polymer coating, characterized in that said pharmaceutical preparation is in the form of a plurality of small bodies, each body comprising a fraction of a therapuetically effective dosage of the cardiac glycoside, whereby each body has a core made up of pharmaceutically indifferent material in a sieve fraction between 0.1 and 3.0 mm, and on said core a first layer made up of a composition comprising the cardiac glycoside, and thereon a second layer comprising an anionic carboxylic polymer being difficultly soluble or insoluble below a given pH value in the interval of pH 4-7.5 but being soluble at a pH above said given value, the weight of the second layer being 1.10 -2 to 30.10 -2 times the weight of the core plus the first layer.
Claim 12
Dependent Claim
136 words
A pharmaceutical preparation comprising a cardiac glycoside with a polymer coating, characterized in that said pharmaceutical preparation is in the form of a plurality of small bodies, each body comprising a fraction of a therapuetically effective dosage of the cardiac glycoside, whereby each body has a core made up of pharmaceutically indifferent material in a sieve fraction between 0.1 and 3.0 mm, and on said core a first layer made up of a composition comprising the cardiac glycoside, and thereon a second layer comprising an anionic carboxylic polymer being difficultly soluble or insoluble below a given pH value in the interval of pH 4-7.5 but being soluble at a pH above said given value, the weight of the second layer being 1.10 -2 to 30.10 -2 times the weight of the core plus the first layer.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-04-20 | 1984-10-20 | 1985-04-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-04-20 | 1988-10-20 | 1989-04-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-04-20 | 1992-10-20 | 1993-04-21 | $7700.00 | Window Closed / Lapsed |