US4600577A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical preparations of pinacidal
Assignee: Leo Pharma AS
•
Filing: 1984-01-23
•
Granted: 1986-07-15
•
Expires: 2004-01-23
Abstract
Abstract New pharmaceutical preparation containing pinacidil (N"-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine) in slow-release form, providing more uniform absorption rates and resulting blood levels when administered to the individual patients.
Inventors
- 👤 Erik J. Didriksen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 08:12
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5084; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K9/5073; A61K9/5078; A61P; A61P9/00; A61P9/12
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
144 words
An improved antihypertensive composition in slow release form comprising an antihypertensive effective amount of N"-cyano-N-4-pyridyl-N'-1,2,2,trimethyl propylguanidine wherein the improvement comprises said propylguanidine being present in the form of a mixture of coated pellets, a portion thereof being: (a) rapid release pellets wherein the coating consists essentially of a copolymer of acrylic and methacrylic ester which releases the contents of the pellet at a pH<4, said coating being present in an amount from 2-10% by weight of the pellets; and (b) the remaining portion being coated pellets wherein the coating consists essentially of an anionic copolymer of methacrylic acid and methacrylic acid ester which releases the contents at a pH in the range of pH 5 to pH 7.5, said coating being present in an amount from 5-20% by weight of the pellets; and wherein the ratio of (a) to (b) is 1:10 to 10:1.
Claim 2
Dependent Claim
144 words
An improved antihypertensive composition in slow release form comprising an antihypertensive effective amount of N"-cyano-N-4-pyridyl-N'-1,2,2,trimethyl propylguanidine wherein the improvement comprises said propylguanidine being present in the form of a mixture of coated pellets, a portion thereof being: (a) rapid release pellets wherein the coating consists essentially of a copolymer of acrylic and methacrylic ester which releases the contents of the pellet at a pH<4, said coating being present in an amount from 2-10% by weight of the pellets; and (b) the remaining portion being coated pellets wherein the coating consists essentially of an anionic copolymer of methacrylic acid and methacrylic acid ester which releases the contents at a pH in the range of pH 5 to pH 7.5, said coating being present in an amount from 5-20% by weight of the pellets; and wherein the ratio of (a) to (b) is 1:10 to 10:1.
Claim 3
Dependent Claim
10 words
Pharmaceutical composition according to claim 1 in dosage unit form.
Claim 4
Dependent Claim
11 words
Pharmaceutical composition according to claim 2 in form of a capsule.
Claim 5
Dependent Claim
22 words
Method for treating patients suffering from hypertension comprising administering to said patients an effective amount of a composition according to claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-07-14 | 1990-01-13 | 1990-07-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-07-14 | 1994-01-13 | 1994-07-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-07-14 | 1998-01-13 | 1998-07-15 | $7700.00 | Window Closed / Lapsed |