US4857052A — Intravenous system for delivering a beneficial ag…

Claim 1

Independent Claim 131 words

A method for adding a beneficial parenterally administrable drug to a parenterally acceptable fluid for forming a parenterally administrable fluid beneficial drug formulation, which method comprises: (a) admitting the parenteral fluid into a formulation chamber, the formulation chamber comprising: (1) a wall surrounding a space provided with a first and second compartment therein; (2) fluid inlet and outlet means communicating with the first compartment to provide a flow path; (3) means for permitting fluid to flow from the flow path through the second compartment; (4) a beneficial parenterally administrable solid drug in the second compartment; and, (b) adding the beneficial drug to the fluid by permitting fluid to flow through the second compartment, wherein the beneficial drug is added to the fluid thereby forming a parenterally administerable fluid beneficial drug formulation.

Claim 2

Independent Claim 131 words

A method for adding a beneficial parenterally administrable drug to a parenterally acceptable fluid for forming a parenterally administrable fluid beneficial drug formulation, which method comprises: (a) admitting the parenteral fluid into a formulation chamber, the formulation chamber comprising: (1) a wall surrounding a space provided with a first and second compartment therein; (2) fluid inlet and outlet means communicating with the first compartment to provide a flow path; (3) means for permitting fluid to flow from the flow path through the second compartment; (4) a beneficial parenterally administrable solid drug in the second compartment; and, (b) adding the beneficial drug to the fluid by permitting fluid to flow through the second compartment, wherein the beneficial drug is added to the fluid thereby forming a parenterally administerable fluid beneficial drug formulation.

Claim 3

Dependent Claim 32 words

The method for adding a beneficial drug to a parenterally acceptable fluid according to claim 1, wherein the beneficial drug is contained in a means for storing and releasing the beneficial drug.

Claim 4

Dependent Claim 27 words

The method for adding a beneficial drug to a parenterally acceptable fluid according to claim 1, wherein the drug is contained in a mass that is microporous.

Claim 5

Dependent Claim 30 words

The method for adding a beneficial drug to a parenterally acceptable fluid according to claim 1, wherein the beneficial drug is contained in a mass transfer conductor for the drug.

Claim 6

Dependent Claim 34 words

The method for adding a beneficial drug to a parenterally acceptable fluid according to claim 1, wherein the compartments are separated by a barrier that permits the passage of fluid into the second compartment.

Claim 7

Dependent Claim 50 words

The method for adding a beneficial drug to a parenterally acceptable fluid according to claim 1, wherein the beneficial drug is added to the fluid to form a solution that passes through a membrane that separates the compartments and then enters the fluid flow path that leaves the formulation chamber.

Claim 8

Dependent Claim 135 words

A formulation chamber for use with a parenteral delivery system for formulating a parenterally administrable drug formulation comprising a parenterally administrable fluid and a parenterally administrable drug, the formulation chamber comprising: (a) a housing means defining a first and second compartment therein; (b) fluid inlet and outlet means for connecting said housing to a parenteral delivery system, said inlet and outlet means communicating with the first compartment to provide a flow path; (c) means for permitting fluid to flow from the flow path into the second compartment; (d) a beneficial parenterally administrable solid drug housed in the second compartment; and, (e) wherein, when the formulation chamber is in use with a parenteral delivery system, parenterally administrable fluid enters the formulation chamber and contacts the parenterally administrable drug for formulating a parenterally administrable drug fluid formulation.

Claim 9

Dependent Claim 135 words

A formulation chamber for use with a parenteral delivery system for formulating a parenterally administrable drug formulation comprising a parenterally administrable fluid and a parenterally administrable drug, the formulation chamber comprising: (a) a housing means defining a first and second compartment therein; (b) fluid inlet and outlet means for connecting said housing to a parenteral delivery system, said inlet and outlet means communicating with the first compartment to provide a flow path; (c) means for permitting fluid to flow from the flow path into the second compartment; (d) a beneficial parenterally administrable solid drug housed in the second compartment; and, (e) wherein, when the formulation chamber is in use with a parenteral delivery system, parenterally administrable fluid enters the formulation chamber and contacts the parenterally administrable drug for formulating a parenterally administrable drug fluid formulation.

Claim 10

Dependent Claim 29 words

The formulation chamber for use with a parenteral delivery system according to claim 7, wherein the beneficial drug is housed in a means for storing and releasing the drug.

Claim 11

Dependent Claim 28 words

The formulation chamber for use with a parenteral delivery system according to claim 7, wherein the beneficial drug is contained in a mass transfer conductor for the drug.

Claim 12

Dependent Claim 23 words

The formulation chamber for use with a parenteral delivery system according to claim 7, wherein the beneficial drug is an intravenously administrable drug.

Claim 13

Dependent Claim 42 words

The formulation chamber for use with a parenteral delivery system according to claim 7, wherein the fluid that flows into the second compartment communicates with the beneficial drug that is housed in a nontoxic mass that releases the drug to the fluid.

Claim 14

Dependent Claim 30 words

The formulation chamber for use with a parenteral delivery system according to claim 7, wherein the compartments are separated by a barrier that is permeable to the passage of fluid.

Claim 15

Dependent Claim 29 words

The formulation chamber for use with a parenteral delivery system according to claim 7, wherein the beneficial drug is housed in a mass that is a drug delivery device.

Claim 16

Dependent Claim 25 words

The formulation chamber for use with a parenteral delivery system according to claim 7, wherein the drug is housed in a mass that is microporous.

Claim 17

Dependent Claim 31 words

The formulation chamber for use with a parenteral delivery system according to claim 7, wherein the beneficial drug is not in the direct path of fluid flow through the formulation chamber.

Claim 18

Dependent Claim 148 words

An intravenous delivery system for administering a drug formulation intravenously in which system the drug formlation is constituted in situ, said system comprising in combination: (a) a container of a pharmaceutically acceptable intravenously administrable fluid; and, (b) a formulation chamber in fluid communication with the container, said formulation chamber comprising: (1) a wall surrounding a space provided with a first and second compartment; (2) fluid inlet means in fluid communication with the container for receiving fluid from the container and fluid outlet means for letting fluid leave the chamber, said inlet and oulet means communicating with the first compartment to provide a flow path; (3) means for permitting fluid to flow from the flow path into the second compartment; and, (4) an intravenously administrable solid drug contained in the second compartment presented in a therapeutically effective amount for producing a beneficial effect in an animal on intravenous therapy.

Claim 19

Dependent Claim 148 words

An intravenous delivery system for administering a drug formulation intravenously in which system the drug formlation is constituted in situ, said system comprising in combination: (a) a container of a pharmaceutically acceptable intravenously administrable fluid; and, (b) a formulation chamber in fluid communication with the container, said formulation chamber comprising: (1) a wall surrounding a space provided with a first and second compartment; (2) fluid inlet means in fluid communication with the container for receiving fluid from the container and fluid outlet means for letting fluid leave the chamber, said inlet and oulet means communicating with the first compartment to provide a flow path; (3) means for permitting fluid to flow from the flow path into the second compartment; and, (4) an intravenously administrable solid drug contained in the second compartment presented in a therapeutically effective amount for producing a beneficial effect in an animal on intravenous therapy.

Claim 20

Dependent Claim 24 words

The intravenous delivery system for administering the drug formulation according to claim 16, wherein a drip chamber is in fluid communication with the container.

Claim 21

Dependent Claim 45 words

The intravenous delivery system for administering the drug formulation according to claim 16, wherein the drug is in a means for storing and releasing the drug to fluid that enters the compartment, which means maintains its physical and chemical integrity in the presence of fluid.

Claim 22

Dependent Claim 21 words

The intravenous delivery system for administering the drug formulation according to claim 16, wherein the compartments are separated by a barrier.

Claim 23

Dependent Claim 27 words

The intravenous delivery system for administering the drug formulation according to claim 16, wherein the compartments are separated by a barrier that permits the passage of fluid.

Claim 24

Dependent Claim 30 words

The intravenous delivery system for administering the drug formulation according to claim 16, wherein the compartments are separated by a membrane and fluid passes through the pores of the membrane.

Claim 25

Dependent Claim 122 words

A formulation chamber comprising: (a) housing means defining a first and second compartment within said housing means; (b) fluid inlet and outlet means in said housing means in fluid communication with said first compartment whereby a primary fluid flow path is provided; (c) means in the formulation chamber for permitting a predetermined portion of the flow of fluid in said fluid flow path to flow through said second compartment; and, (d) said second compartment adapted to retain a biologically beneficial drug in solid form, and wherein when the second compartment contains a therapeutically effective amount of drug and the formulation chamber is in use, fluid enters the second compartment and forms with the drug a fluid drug formulation useful for intravenous therapy.

Claim 26

Dependent Claim 122 words

A formulation chamber comprising: (a) housing means defining a first and second compartment within said housing means; (b) fluid inlet and outlet means in said housing means in fluid communication with said first compartment whereby a primary fluid flow path is provided; (c) means in the formulation chamber for permitting a predetermined portion of the flow of fluid in said fluid flow path to flow through said second compartment; and, (d) said second compartment adapted to retain a biologically beneficial drug in solid form, and wherein when the second compartment contains a therapeutically effective amount of drug and the formulation chamber is in use, fluid enters the second compartment and forms with the drug a fluid drug formulation useful for intravenous therapy.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1992-08-14	1993-02-13	1993-08-15	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1996-08-14	1997-02-13	1997-08-15	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2000-08-14	2001-02-13	2001-08-15	$7700.00	Window Closed / Lapsed

Intravenous system for delivering a beneficial agent

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