US4845216A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pyrido [2,3,d]pyrimidine derivatives
Assignee: Princeton University
•
Filing: 1987-07-17
•
Granted: 1989-07-04
•
Expires: 2007-07-17
Abstract
Abstract 2,4-Diamino- and 2-amino-4-hydroxy- derivatives of N-(4-[2-(pyrido[2,3-d]pyrimidin-6-yl)alkyl]benzoyl)-L-glutamic acids, and the corresponding 5,6,7,8-tetrahydro compounds are antineoplastic agents. The compounds are prepared by hydrolytic or hydrogenolytic removal of carboxylic acid protecting groups from the correspondingly protected glutamic acid derivatives. A typical embodiment is N-)4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6- yl)ethyl]benzoyl)-L-glutamic acid.
Inventors
- 👤 Edward C. Taylor
- 👤 George P. Beardsley
- 👤 Peter J. Harrington
- 👤 Stephen R. Fletcher
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 17:45
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
61 words
A compound selected from the group consisting of: (i) pyrido[2,3-d]pyrimidines of the formula: ##STR18## wherein: R 1 is amino or hydroxy; R 3 is hydrogen, methyl, or ethyl; and the configuration about the carbon atom designated * is L; (ii) the tautomeric forms thereof; and (iii) the pharmaceutically acceptable alkali metal, alkaline earth, non-toxic metal, ammonium, and substituted ammonium salts thereof.
Claim 2
Dependent Claim
61 words
A compound selected from the group consisting of: (i) pyrido[2,3-d]pyrimidines of the formula: ##STR18## wherein: R 1 is amino or hydroxy; R 3 is hydrogen, methyl, or ethyl; and the configuration about the carbon atom designated * is L; (ii) the tautomeric forms thereof; and (iii) the pharmaceutically acceptable alkali metal, alkaline earth, non-toxic metal, ammonium, and substituted ammonium salts thereof.
Claim 3
Dependent Claim
10 words
The compound according to claim 1 which is N-(4-[2-(2-amino-4-hydroxypyrido[2,3-d]pyrimidin-6-yl)ethyl]-benzoyl)-L-glutamic acid.
Claim 4
Dependent Claim
10 words
The compound according to claim 1 which is N-(4-[1-(2-amino-4-hydroxypyrido[2,3-d]pyrimidin-6-yl)prop-2-yl]benzoyl)-L-glutamic acid.
Claim 5
Dependent Claim
10 words
The compound according to claim 1 which is N-(4-[1-(2-amino-4-hydroxypyrido[2,3-d]pyrimidin-6-yl)but-2-yl]benzoyl)-L-glutamic acid.
References Cited (Backward Citations)
US3856959A
Cited
GB1534238A
Cited
US4172200A
Cited
US4369319A
Cited
US4564616A
Cited
US4512992A
Cited
US4431805A
Cited
US4526964A
Cited
US4536575A
Cited
US4460591A
Cited
US4532241A
Cited
US4432981A
Cited
WO1984004040A1
Cited
US4746659A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-03 | 1993-01-02 | 1993-07-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-03 | 1997-01-02 | 1997-07-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-03 | 2001-01-02 | 2001-07-04 | $7700.00 | Window Closed / Lapsed |