US4526964A
Expired / Lapsed
US
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2,4-Diamino-6-(hydroxymethyl)pyrido[2,3-d]pyrimidine
Assignee: Southern Research Institute
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Filing: 1982-08-31
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Granted: 1985-07-02
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Expires: 2002-08-31
Abstract
Abstract There is disclosed a novel intermediate useful in the preparation of pyrido [2,3-d] pyrimidines, which includes N-[4-[(2-amino-4(3H)-oxopyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]-L-glutamic acid (5-deazafolic acid), N-[4-[[2-amino-4(3H)-oxopyrido[2,3-d]-pyrimidin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid (5-deaza-N 10 -methylfolic acid), N-(4-[(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]-L-glutamic acid (5-deazaaminopterin), and N-[4-[[2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid (5-deazamethotrexate). This intermediate is the compound 2,4-diamino-6-(hydroxymethyl)pyrido-[2,3-d]pyrimidine.
Inventors
- 👤 Carroll G. Temple
- 👤 John A. Montgomery
- 👤 Robert D. Elliott
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 17:45
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/6561
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
39 words
Intermediates useful in the production of 5-deaza analogs of folic acid, N 10 -substituted folic acid, aminopterin, and N 10 -substituted aminopterin consisting of compounds having the structure: ##STR13## wherein Y is CH 2 OH or CH 2 Br.
Claim 2
Dependent Claim
39 words
Intermediates useful in the production of 5-deaza analogs of folic acid, N 10 -substituted folic acid, aminopterin, and N 10 -substituted aminopterin consisting of compounds having the structure: ##STR13## wherein Y is CH 2 OH or CH 2 Br.
Claim 3
Dependent Claim
1 words
2,4-Diamino-6-(hydroxymethyl)pyrido[2,3-d]pyrimidine.
Claim 4
Dependent Claim
1 words
2,4-Diamino-6-(hydroxymethyl)pyrido[2,3-d]pyrimidine.
References Cited (Backward Citations)
US3021332A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-07-01 | 1988-12-31 | 1989-07-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-07-01 | 1992-12-31 | 1993-07-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-07-01 | 1996-12-31 | 1997-07-02 | $7700.00 | Window Closed / Lapsed |